Venetoclax

44 interactions 4 explained in plain English
Also sold as: Venclexta Venclexta®
About Venetoclax

Venetoclax is used alone or in combination with obinutuzumab (Gazyva) or rituximab (Rituxan) to treat certain types of chronic lymphocytic leukemia (CLL; a type of cancer that begins in the white blood cells) or certain types of small lymphocytic lymphoma (SLL; a type of cancer that begins mostly in the lymph nodes). I… Read the full Venetoclax drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Venetoclax Relugolix Orgovyx Explained Increased relugolix exposure Details Venetoclax Colchicine Colcrys Explained Increased exposure of P-gp substrate and an increased toxicities of these substrates Details Venetoclax Abrocitinib Cibinqo Explained Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Venetoclax Aliskiren Tekturna Increased exposure of P-gp substrate and an increased toxicities of these substrates Details Venetoclax Azithromycin AzaSite Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Venetoclax Betrixaban Bevyxxa® Increased exposure of P-gp substrate and an increased toxicities of these substrates Details Venetoclax Atorvastatin Atorvaliq Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Venetoclax Alogliptin Nesina Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Venetoclax Canagliflozin Invokana Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Venetoclax Capmatinib Tabrecta Increased P-gp substrate exposure and an increased risk of increased adverse reactions Details Venetoclax Captopril Capoten® Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Venetoclax Cyclosporine Injection Atopica Increased cycloSPORINE exposure, increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk o... Details Venetoclax Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure, increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk o... Details Venetoclax Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Venetoclax Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Venetoclax Digoxin Cardoxin® Increased exposure of P-gp substrate and an increased toxicities of these substrates Details Venetoclax Doxorubicin Adriamycin Increased exposure of P-gp substrate and an increased toxicities of these substrates Details Venetoclax Elacestrant Orserdu Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Venetoclax Enasidenib Idhifa Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Venetoclax Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Venetoclax Entrectinib Rozlytrek Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Venetoclax Everolimus Afinitor Increased exposure of P-gp substrate and an increased toxicities of these substrates Details Venetoclax Felodipine Plendil® Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Venetoclax Fexofenadine Allegra Increased exposure of P-gp substrate and an increased toxicities of these substrates Details Venetoclax Fostamatinib Tavalisse Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Venetoclax Ibrexafungerp Brexafemme Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Venetoclax Istradefylline Nourianz Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Venetoclax Ketoconazole Topical Extina® Foam Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Venetoclax Lefamulin Xenleta Increased lefamulin exposure, an increased risk of lefamulin-related adverse reactions and increased sensitive CYP3A4 substrate ex... Details Venetoclax Lenacapavir Injection Sunlenca Increased sensitive P-gp/CYP3A substrate exposure and an increased risk of sensitive P-gp/CYP3A substrate-related adverse effects Details Venetoclax Lenacapavir Oral Sunlenca Increased sensitive P-gp/CYP3A substrate exposure and an increased risk of sensitive P-gp/CYP3A substrate-related adverse effects Details Venetoclax Letermovir Injection Prevymis Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Venetoclax Loperamide Diamode Increased exposure of P-gp substrate and an increased toxicities of these substrates Details Venetoclax Maraviroc Selzentry Increased exposure of P-gp substrate and an increased toxicities of these substrates Details Venetoclax Meloxicam Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Venetoclax Meloxicam Injection Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Venetoclax Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Venetoclax Morphine Injection Astramorph® PF Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Venetoclax Nafcillin Injection Unipen® Injection Reduced exposure to venetoclax and reduced venetoclax efficacy Details Venetoclax Naldemedine Symproic Increased exposure of P-gp substrate and an increased toxicities of these substrates Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.