Venetoclax

Name: Venetoclax Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

44 interactions 4 explained in plain English

Also sold as: Venclexta Venclexta®

About Venetoclax

Venetoclax is used alone or in combination with obinutuzumab (Gazyva) or rituximab (Rituxan) to treat certain types of chronic lymphocytic leukemia (CLL; a type of cancer that begins in the white blood cells) or certain types of small lymphocytic lymphoma (SLL; a type of cancer that begins mostly in the lymph nodes). I… Read the full Venetoclax drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Canagliflozin Olutasidenib Everolimus Aliskiren Enasidenib Betrixaban

43 Major 1 Moderate

All (44) Major (43) Moderate (1)

Major

Venetoclax Neratinib Nerlynx Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Venetoclax Nifedipine Adalat® Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Venetoclax Olutasidenib Rezlidhia Reduced sensitive CYP3A substrate exposure Details

Moderate

Venetoclax Trospium / Xanomeline Cobenfy Explained Increased oral sensitive CYP3A4 substrate exposure and an increased risk on severity and frequency of sensitive CYP3A4 substrate-r... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.