Voclosporin

92 interactions 7 explained in plain English
Also sold as: Lupkynis Lupkynis®
About Voclosporin

Voclosporin is used in combination with other mycophenolate mofetil (Cellcept) and corticosteroids like methylprednisolone or prednisone for treatment of lupus nephritis (an autoimmune disease in which the immune system attacks the kidneys) in adults. Voclosporin is in a class of medications called immunosupressants. I… Read the full Voclosporin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lefamulin Ketoconazole Topical Oxaliplatin Injection Hydroxychloroquine Atogepant Ivabradine
2 Contraindicated 89 Major 1 Moderate
All (92) Contraindicated (2) Major (89) Moderate (1)

Contraindicated

Voclosporin Ketoconazole Topical Extina® Foam Increased voclosporin exposure and an increased risk of QT interval prolongation Details Voclosporin Lefamulin Xenleta Increased lefamulin exposure, an increased risk of lefamulin-related adverse reactions, increased voclosporin exposure, an increas... Details

Major

Voclosporin Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Voclosporin Sertraline Explained An increased risk of QT interval prolongation Details Voclosporin Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Voclosporin Relugolix Orgovyx Explained Increased relugolix exposure and an increased risk of QT interval prolongation Details Voclosporin Colchicine Colcrys Explained Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse effects Details Voclosporin Simvastatin Flolipid Explained Increased simvastatin exposure and an increased risk of myopathy and rhabdomyolysis Details Voclosporin Amisulpride Injection Barhemsys An increased risk of QT interval prolongation Details Voclosporin Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Voclosporin Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Voclosporin Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Voclosporin Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation Details Voclosporin Atogepant Qulipta Increased OATP1B1/OATP1B3 substrate exposure Details Voclosporin Azithromycin AzaSite An increased risk of QT interval prolongation Details Voclosporin Atorvastatin Atorvaliq Increased OATP1B1/OATP1B3 substrate exposure Details Voclosporin Alfuzosin UroXatral An increased risk of QT interval prolongation Details Voclosporin Anagrelide Agrylin An increased risk of QT interval prolongation Details Voclosporin Axitinib Inlyta Increased OATP1B1 substrate exposure Details Voclosporin Bedaquiline Sirturo An increased risk of QT interval prolongation Details Voclosporin Chloroquine Aralen® An increased risk of QT interval prolongation Details Voclosporin Cyclosporine Injection Atopica Increased cycloSPORINE exposure Details Voclosporin Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure Details Voclosporin Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Voclosporin Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Voclosporin Dasatinib Phyrago An increased risk of QT interval prolongation Details Voclosporin Degarelix Injection Firmagon An increased risk of QT interval prolongation Details Voclosporin Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Voclosporin Digoxin Cardoxin® Increased digoxin exposure Details Voclosporin Disopyramide Norpace An increased risk of QT interval prolongation Details Voclosporin Docetaxel Beizray Increased OATP1B1/OATP1B3 substrate exposure Details Voclosporin Docetaxel Injection Beizray Increased OATP1B1/OATP1B3 substrate exposure Details Voclosporin Dofetilide Tikosyn An increased risk of QT interval prolongation Details Voclosporin Dolasetron Anzemet An increased risk of QT interval prolongation Details Voclosporin Dolasetron Injection Anzemet An increased risk of QT interval prolongation Details Voclosporin Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Voclosporin Eluxadoline Viberzi Increased OATP1B1 substrate exposure Details Voclosporin Encorafenib Braftovi Reduced voclosporin exposure, reduced efficacy of voclosporin and an increased risk of QT interval prolongation and torsade de poi... Details Voclosporin Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Voclosporin Eribulin Injection Halaven An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.