Yohimbine

47 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Sertraline Abiraterone
2 Major 45 Moderate
All (47) Major (2) Moderate (45)

Major

Yohimbine Sertraline Explained Increased CYP2D6 substrate exposure Details Yohimbine Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details

Moderate

Yohimbine Lisinopril Prinivil Explained Reduced angiotensin converting enzyme inhibitor effectiveness Details Yohimbine Atenolol Tenormin Explained Reduced beta-adrenergic blocker effectiveness Details Yohimbine Acebutolol Sectral® Reduced beta-adrenergic blocker effectiveness Details Yohimbine Benazepril Lotensin Reduced angiotensin converting enzyme inhibitor effectiveness Details Yohimbine Alfuzosin UroXatral Reduced alpha-1 adrenergic blocker effectiveness Details Yohimbine Amlodipine Amvaz® Reduced calcium channel blocker effectiveness Details Yohimbine Betaxolol Betoptic S Reduced beta-adrenergic blocker effectiveness Details Yohimbine Betaxolol Ophthalmic Betoptic® Reduced beta-adrenergic blocker effectiveness Details Yohimbine Bisoprolol Zebeta® Reduced beta-adrenergic blocker effectiveness Details Yohimbine Candesartan Atacand Reduced angiotensin II receptor antagonist effectiveness Details Yohimbine Captopril Capoten® Reduced angiotensin converting enzyme inhibitor effectiveness Details Yohimbine Clonidine Transdermal Patch Catapres Reduced clonidine effectiveness Details Yohimbine Doxazosin Cardura Reduced alpha-1 adrenergic blocker effectiveness Details Yohimbine Enalapril Epaned Reduced angiotensin converting enzyme inhibitor effectiveness Details Yohimbine Eprosartan Teveten® Reduced angiotensin II receptor antagonist effectiveness Details Yohimbine Esmolol Brevibloc Reduced beta-adrenergic blocker effectiveness Details Yohimbine Felodipine Plendil® Reduced calcium channel blocker effectiveness Details Yohimbine Fosinopril Monopril® Reduced angiotensin converting enzyme inhibitor effectiveness Details Yohimbine Furosemide Injection Disal Reduced diuretic effectiveness Details Yohimbine Guanabenz Wytensin® Reduced guanabenz effectiveness Details Yohimbine Guanfacine Intuniv Reduced guanfacine effectiveness Details Yohimbine Hydralazine Apresoline® Reduced hydrALAZINE effectiveness Details Yohimbine Irbesartan Avapro Reduced angiotensin II receptor antagonist effectiveness Details Yohimbine Isradipine DynaCirc® Reduced calcium channel blocker effectiveness Details Yohimbine Labetalol Normodyne® Reduced beta-adrenergic blocker effectiveness Details Yohimbine Levobunolol Ophthalmic AKBeta® Reduced beta-adrenergic blocker effectiveness Details Yohimbine Lithium Carbonate Lithobid Increased risk of manic episodes Details Yohimbine Losartan Arbli Reduced angiotensin II receptor antagonist effectiveness Details Yohimbine Methyldopa Aldomet® Reduced methyldopa effectiveness Details Yohimbine Minoxidil Loniten® Reduced minoxidil effectiveness Details Yohimbine Minoxidil Topical Rogaine Reduced minoxidil effectiveness Details Yohimbine Moexipril Univasc® Reduced angiotensin converting enzyme inhibitor effectiveness Details Yohimbine Morphine Injection Astramorph® PF Increased analgesic and adverse effects of morphine Details Yohimbine Nadolol Corgard Reduced beta-adrenergic blocker effectiveness Details Yohimbine Naloxone Kloxxado Increased adverse effects Details Yohimbine Naloxone Injection Evzio® Increased adverse effects Details Yohimbine Naloxone Nasal Spray Kloxxado Increased adverse effects Details Yohimbine Nebivolol Bystolic Reduced beta-adrenergic blocker effectiveness Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.