Zinc

Name: Zinc Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

15 interactions

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Baloxavir Marboxil Dolutegravir

2 Major 13 Moderate

All (15) Major (2) Moderate (13)

Major

Zinc Baloxavir Marboxil Xofluza Decreased baloxavir concentration Details Zinc Dolutegravir Juluca® (as a combination product containing dolutegravir, rilpivirine) Reduced dolutegravir exposure and reduced efficacy of dolutegravir Details

Moderate

Zinc Deferiprone Ferriprox Decreased absorption of minerals Details Zinc Delafloxacin Baxdela Decreased delafloxacin efficacy Details Zinc Delafloxacin Injection Baxdela Decreased delafloxacin efficacy Details Zinc Gatifloxacin Ophthalmic Zymar® Decreased gatifloxacin effectiveness Details Zinc Gemifloxacin Factive Decreased gemifloxacin absorption Details Zinc Levofloxacin Levaquin Decreased levofloxacin effectiveness Details Zinc Levofloxacin Injection Levaquin Decreased levofloxacin effectiveness Details Zinc Moxifloxacin Avelox Decreased moxifloxacin effectiveness Details Zinc Moxifloxacin Injection Avelox Decreased moxifloxacin effectiveness Details Zinc Moxifloxacin Ophthalmic Moxeza® Decreased moxifloxacin effectiveness Details Zinc Ofloxacin Floxin® Decreased efficacy of ofloxacin Details Zinc Ofloxacin Ophthalmic Ocuflox Decreased efficacy of ofloxacin Details Zinc Ofloxacin Otic Floxin® Otic Decreased efficacy of ofloxacin Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.