Zofenopril

Name: Zofenopril Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

12 interactions

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Azathioprine Everolimus Lithium Carbonate Mercaptopurine

4 Major 8 Moderate

All (12) Major (4) Moderate (8)

Major

Zofenopril Azathioprine Azasan Myelosuppression Details Zofenopril Everolimus Afinitor Increased risk of angioedema Details Zofenopril Lithium Carbonate Lithobid Increased risk of lithium toxicity Details Zofenopril Mercaptopurine Purinethol® Myelosuppression Details

Moderate

Zofenopril Aspirin Acuprin® Decreased zofenopril effectiveness Details Zofenopril Aspirin Rectal Aspirin Decreased zofenopril effectiveness Details Zofenopril Capsaicin Arthricare for Women Moisturizing Increased risk of cough Details Zofenopril Capsaicin Topical Aspercreme Warming® Increased risk of cough Details Zofenopril Capsaicin Transdermal Patch Aspercreme Warming® Patch Increased risk of cough Details Zofenopril Cyclosporine Injection Atopica Acute renal dysfunction Details Zofenopril Cyclosporine Ophthalmic Cequa Acute renal dysfunction Details Zofenopril Lanthanum Fosrenol® Reduced bioavailability of ACE inhibitors Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.