1-epiandrosterone + Cinacalcet
Cinacalcet brand name: Sensipar.
We found no known interaction between 1-epiandrosterone and Cinacalcet in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Cinacalcet states a food rule worth keeping to.
1-epiandrosterone and Cinacalcet
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Cinacalcet and 1-epiandrosterone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for 1-epiandrosterone at all — not against Cinacalcet, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
1-epiandrosterone safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
1-epiandrosterone in Pregnancy & Breastfeeding
When used orally. Prohormones can be converted to active hormones in the body and cause adverse effects such as menstrual irregularities, infertility, hair loss, and acne. Prohormones have also been associated with hepatotoxicity and increased risk of cardiovascular disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing prohormones are dangerous. Avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Cinacalcet Products Have a Food Rule — 1-epiandrosterone Should Not Break It
At least one FDA label for a product containing Cinacalcet says to take it with food. If you take 1-epiandrosterone on an empty stomach out of habit, keep them separate — and take Cinacalcet with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Cinacalcet products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Cinacalcet tablets should be taken with food or shortly after a meal ( 2.1 ) • Tablets should always be taken whole and not divided ( 2.1 ) • Secondary HPT in patients with CKD on dialysis ( 2.2 ): o Starting dose is 30 mg once daily.
From the Dosage and Administration section of the FDA label we read for Cinacalcet — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Cinacalcet
This page covers 1-epiandrosterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cinacalcet page lists 17 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 9 minor.
From our pharmacist’s overview on the Cinacalcet page
“Cinacalcet (Sensipar) is dosed carefully against blood calcium and parathyroid hormone levels, usually in people with kidney disease, so anything that changes how much of a dose actually gets absorbed deserves real attention. All 17 supplement interactions on file share a single mechanism.”
Reviewed by 2 · Jul 18, 2026
Where 1-epiandrosterone and Cinacalcet Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,354 of 1,452 supplements looked up here in the last 7 days
#1,418 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 1-epiandrosterone reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The 1-epiandrosterone and Cinacalcet records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About 1-epiandrosterone
What is 1-epiandrosterone?
- Muscle building
- Athletic performance
- Improving body composition
- Strength gains
1-epiandrosterone (often sold as a '1-andro' prohormone) is a steroid-related compound marketed to bodybuilders for muscle and strength gains, but solid human evidence is very limited and the safety profile is poorly understood. Because it can act like an anabolic steroid in the body and may carry liver, hormonal, and cardiovascular risks, most people should avoid it and talk to a pharmacist or doctor first.
Not a plant; a synthetic or lab-made steroid compound (prohormone) · Capsules, tablets, sometimes part of multi-ingredient bodybuilding 'prohormone' supplements
An interaction check asks whether these two react with each other — it does not ask whether 1-epiandrosterone is a good idea for someone in your situation. Here is what our 1-epiandrosterone record says about it on its own.
1-epiandrosterone: dosing
There is no established safe or effective dose for 1-epiandrosterone. Because these products can act like steroids and may carry real risks, do not assume "more is better." The safest choice for most people is to avoid it.
From our 1-epiandrosterone monograph — the full record covers uses, side effects and every documented interaction.
About Cinacalcet
What Is Cinacalcet Used For?
Brand name: Sensipar
Cinacalcet tablets are used to treat secondary hyperparathyroidism (overactive parathyroid glands caused by kidney disease) in adult patients with chronic kidney disease (CKD) who are on dialysis. This use applies to cinacalcet tablets, cinacalcet hydrochloride tablets, and Sensipar. Importantly, cinacalcet is not approved for CKD patients who are not on dialysis, due to a higher risk of dangerously low calcium levels.
Cinacalcet tablets are also used to lower high calcium levels (hypercalcemia) in adults with parathyroid carcinoma (a rare cancer of the parathyroid gland), and in adults with primary hyperparathyroidism who need surgery based on their calcium levels but cannot have that surgery.
Most-Reported Side Effects for Cinacalcet
From FAERS, the FDA’s public side-effect reporting system (48,763 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & 1-epiandrosterone
Browse every other medication we’ve checked against 1-epiandrosterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked 1-epiandrosterone against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Valacyclovir ›
- Warfarin Sodium ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full 1-epiandrosterone list.
1-epiandrosterone References
The 1 references that drive our 1-epiandrosterone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking 1-epiandrosterone and Cinacalcet Together: Common Questions
Is it safe to take 1-epiandrosterone with Cinacalcet?
Should I take 1-epiandrosterone and Cinacalcet at the same time of day?
Does Cinacalcet interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.