19-nor-dhea + Darolutamide
Darolutamide brand name: Nubeqa.
We found no known interaction between 19-nor-dhea and Darolutamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Darolutamide states a food rule worth keeping to.
19-nor-dhea and Darolutamide
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Darolutamide and 19-nor-dhea in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
19-nor-dhea safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Darolutamide
Interactions in our licensed database are recorded against drug classes, not just single drug names. Darolutamide is filed under 3 classifications — p-glycoprotein substrates, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. 19-nor-dhea has documented interactions with 1 drug class — the most serious being testosterone (moderate) — and none of Darolutamide’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
19-nor-dhea Does Interact With Other Medications
19-nor-dhea has 8 moderate known drug interactions in our database — Darolutamide isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against 19-nor-dhea
We haven’t checked that one against 19-nor-dhea yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against 19-nor-dhea. Pick one to open its full report.
Some Darolutamide Products Have a Food Rule — 19-nor-dhea Should Not Break It
At least one FDA label for a product containing Darolutamide says to take it with food. If you take 19-nor-dhea on an empty stomach out of habit, keep them separate — and take Darolutamide with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Darolutamide products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
Take NUBEQA with food.
From the Dosage and Administration section of the FDA label we read for Darolutamide — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Darolutamide
This page covers 19-nor-dhea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Darolutamide page lists 144 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 103 moderate · 38 minor.
From our pharmacist’s overview on the Darolutamide page
“Darolutamide (Nubeqa) treats prostate cancer, and supplements deserve real caution alongside it, because most of those listed here can change how much of the drug stays in your blood. Nearly all act on CYP3A4, the liver enzyme that breaks darolutamide down, or on the transport proteins that move it through cells.”
Reviewed by 2 · Jul 18, 2026
Taking 19-nor-dhea as Part of a Dietary Supplement Product? Check It for Interactions
We hold 12 real supplement products containing 19-nor-dhea, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 19-nor-dhea. Even though 19-nor-dhea itself has no known interaction with Darolutamide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where 19-nor-dhea and Darolutamide Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,096 of 1,452 supplements looked up here in the last 7 days
#1,275 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. 19-nor-dhea is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 19-nor-dhea reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The 19-nor-dhea and Darolutamide records this page draws on were last updated June 20, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About 19-nor-dhea
What is 19-nor-dhea?
- Muscle building and bodybuilding
- Increasing strength
- Athletic performance
- Supporting hormone levels
- Body recomposition
19-nor-DHEA is a synthetic 'prohormone' marketed to bodybuilders as a precursor to nandrolone-like compounds, not a natural plant supplement. There is very little reliable human research on its safety or effectiveness, and products like it carry real risks to the liver, hormones, and heart. We do not recommend using it without close medical supervision, and it may be banned in sports and restricted by law in some places.
Not applicable (a synthetic or semi-synthetic hormone derivative, not a plant part) · Capsules, tablets, sublingual tablets, sometimes combined in 'prohormone' supplement blends
An interaction check asks whether these two react with each other — it does not ask whether 19-nor-dhea is a good idea for someone in your situation. Here is what our 19-nor-dhea record says about it on its own.
19-nor-dhea: dosing
There is no established or medically recommended dose for 19-nor-DHEA. It has not been studied well enough to define a safe and effective amount.Products vary widely, and labels may not be accurate. Because of this, we cannot suggest a specific milligram amount.
From our 19-nor-dhea monograph — the full record covers uses, side effects and every documented interaction.
About Darolutamide
What Is Darolutamide Used For?
Brand name: Nubeqa
Nubeqa (darolutamide) tablets are approved for adult men with two forms of advanced prostate cancer. The first is non-metastatic castration-resistant prostate cancer (nmCRPC) — cancer that keeps growing despite hormone-lowering therapy and has not yet spread to other parts of the body. The second is metastatic castration-sensitive prostate cancer (mCSPC) — cancer that has spread but still responds to hormone-lowering treatment.
For mCSPC, Nubeqa can be used alone or in combination with docetaxel (a chemotherapy medicine). In all cases, patients also receive a gonadotropin-releasing hormone (GnRH) agonist or antagonist — a medicine that lowers testosterone — or have already had surgery to remove the testicles.
Most-Reported Side Effects for Darolutamide
From FAERS, the FDA’s public side-effect reporting system (5,501 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & 19-nor-dhea
Browse every other medication we’ve checked against 19-nor-dhea — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
8 interactions
No interaction 2,821 drugs checked — show the list
We also checked 19-nor-dhea against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Lisinopril ›
- Amoxicillin ›
- Isotretinoin ›
- Methotrexate ›
- Amlodipine Besylate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,821 medications checked with no known interaction — see the full 19-nor-dhea list.
19-nor-dhea References
The 4 sources that drive our 19-nor-dhea monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. 19-nor-dhea is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- DHEA — MedlinePlus (NIH) Source
- Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements Source
- Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
- FDA 101: Dietary Supplements — U.S. Food and Drug Administration Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking 19-nor-dhea and Darolutamide Together: Common Questions
Is it safe to take 19-nor-dhea with Darolutamide?
Should I take 19-nor-dhea and Darolutamide at the same time of day?
How was the 19-nor-dhea and Darolutamide combination checked?
Does 19-nor-dhea interact with any other medications?
Does Darolutamide interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.