Drug & supplement interaction

19-nor-dhea + Sertraline

Sertraline brand name: Zoloft.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between 19-nor-dhea and Sertraline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

19-nor-dhea and Sertraline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sertraline and 19-nor-dhea in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

19-nor-dhea safety at a glance

19-nor-dhea overall Avoid It is an unproven hormonal prohormone with potential serious side effects and little safety data.
Pregnancy Avoid Hormone-altering products should not be used during pregnancy.
Breastfeeding Avoid Avoid while breastfeeding due to hormonal effects and lack of safety data.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sertraline and 19-nor-dhea? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sertraline

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sertraline is filed under 13 classifications — including antidepressant drugs, cytochrome p450 2c19 (cyp2c19) inhibitors, cytochrome p450 2c9 (cyp2c9) inhibitors. 19-nor-dhea has documented interactions with 1 drug class — the most serious being testosterone (moderate) — and none of Sertraline’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

19-nor-dhea Does Interact With Other Medications

19-nor-dhea has 8 moderate known drug interactions in our database — Sertraline isn’t one of them. If you take anything else, check it against the full list below.

Moderate 8 No known interaction 2,822 (incl. Sertraline)
Taking anything else?

Check Another of Your Medications Against 19-nor-dhea

Covers the 2,830 medications we’ve checked against 19-nor-dhea. Pick one to open its full report.

What to actually watch for

What Sertraline’s Own FDA Label Lists

This is not an interaction — none of it involves 19-nor-dhea. These are the most notable effects listed in the ADVERSE REACTIONS section of Sertraline’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 7 of them are worth acting on rather than waiting out — marked below.

  • Mania or an unusually elevated mood Worth acting on
  • Serotonin syndrome Worth acting on
  • Thoughts of self-harm Worth acting on
  • Low sodium Worth acting on
  • Seizures Worth acting on
  • Bleeding or bruising Worth acting on
  • An allergic reaction Worth acting on
  • Loss of bladder control
  • A change in sex drive
  • Erection problems

Showing the 10 most notable of 32 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Sertraline. Read the label on DailyMed › Where a percentage is shown, it is the share of 214,799 voluntary FDA FAERS reports for Sertraline that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. 19-nor-dhea’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no 19-nor-dhea side to compare — that is a limit of the record, not a statement that 19-nor-dhea has no side effects.

From our Q&A

Questions About 19-nor-dhea or Sertraline

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers 19-nor-dhea or Sertraline, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Sertraline

This page covers 19-nor-dhea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sertraline page lists 188 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 9 major · 139 moderate · 40 minor.

From our pharmacist’s overview on the Sertraline page

“If you take sertraline (Zoloft) for depression, anxiety, or panic, treat this page with real care. Nine of the 188 supplements here carry a major rating, and the biggest issue is how your body clears the drug.”

Reviewed by 2 · Jul 18, 2026

Open the Sertraline interaction page

One more smart check

Taking 19-nor-dhea as Part of a Dietary Supplement Product? Check It for Interactions

We hold 12 real supplement products containing 19-nor-dhea, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 19-nor-dhea. Even though 19-nor-dhea itself has no known interaction with Sertraline, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where 19-nor-dhea and Sertraline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 19-nor-dhea
Top half

#641 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sertraline
Top 10

#5 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. 19-nor-dhea is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 19-nor-dhea reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The 19-nor-dhea and Sertraline records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 19-nor-dhea

What is 19-nor-dhea?

  • Muscle building and bodybuilding
  • Increasing strength
  • Athletic performance
  • Supporting hormone levels
  • Body recomposition

19-nor-DHEA is a synthetic 'prohormone' marketed to bodybuilders as a precursor to nandrolone-like compounds, not a natural plant supplement. There is very little reliable human research on its safety or effectiveness, and products like it carry real risks to the liver, hormones, and heart. We do not recommend using it without close medical supervision, and it may be banned in sports and restricted by law in some places.

Not applicable (a synthetic or semi-synthetic hormone derivative, not a plant part) · Capsules, tablets, sublingual tablets, sometimes combined in 'prohormone' supplement blends

An interaction check asks whether these two react with each other — it does not ask whether 19-nor-dhea is a good idea for someone in your situation. Here is what our 19-nor-dhea record says about it on its own.

19-nor-dhea: dosing

There is no established or medically recommended dose for 19-nor-DHEA. It has not been studied well enough to define a safe and effective amount.Products vary widely, and labels may not be accurate. Because of this, we cannot suggest a specific milligram amount.

From our 19-nor-dhea monograph — the full record covers uses, side effects and every documented interaction.

Read the full 19-nor-dhea monograph & all interactions
Medication

About Sertraline

What Is Sertraline Used For?

Brand name: Zoloft

Sertraline treats a range of mental health conditions. All formulations are approved for major depressive disorder (MDD) in adults and obsessive-compulsive disorder (OCD). The oral solution (including Zoloft oral solution) and several tablet formulations are also approved for panic disorder, post-traumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD).

For OCD specifically, the capsule formulations and some tablet products are approved for use in adults and children aged 6 and older. Sertraline hydrochloride tablets (plain, not film-coated) are approved for OCD in pediatric patients as well. However, sertraline is not approved for major depressive disorder in children — only in adults.

Most-Reported Side Effects for Sertraline

From FAERS, the FDA’s public side-effect reporting system (218,320 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 13,865 reports
Fatigue 12,822 reports
Headache 11,106 reports
Anxiety 10,369 reports
Diarrhea 10,339 reports
See full Sertraline drug information
Keep checking

Other Drugs & 19-nor-dhea

Browse every other medication we’ve checked against 19-nor-dhea — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
8Moderate
0Minor
2,821No known interaction
8 Moderate 2,821 No interaction
Moderate

8 interactions

No interaction 2,821 drugs checked — show the list

We also checked 19-nor-dhea against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,821 medications checked with no known interaction — see the full 19-nor-dhea list.

See the full 19-nor-dhea interactions page
See every supplement checked against Sertraline, ranked by severity
Evidence & sources

19-nor-dhea References

The 4 sources that drive our 19-nor-dhea monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. 19-nor-dhea is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. DHEA — MedlinePlus (NIH) Source
  2. Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements Source
  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  4. FDA 101: Dietary Supplements — U.S. Food and Drug Administration Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 19-nor-dhea and Sertraline Together: Common Questions

Is it safe to take 19-nor-dhea with Sertraline?
We do not list a known interaction between 19-nor-dhea and Sertraline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the 19-nor-dhea and Sertraline combination checked?
Interactions in our licensed database are recorded against drug classes. Sertraline is filed under 13 classifications, and 19-nor-dhea has documented interactions with 1 drug class — none of Sertraline's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does 19-nor-dhea interact with any other medications?
Yes. 19-nor-dhea has 8 documented drug interactions in our database — Sertraline is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sertraline interact with any supplements?
Yes. Sertraline has documented interactions with 188 supplements in our database — 19-nor-dhea is not one of them. The Sertraline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

19-nor-dhea monograph Uses, safety profile, and every drug interaction in one place Sertraline drug information The full plain-English guide to this medication Sertraline supplement interactions Every supplement checked against Sertraline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sertraline and 19-nor-dhea?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.