Drug & supplement interaction

19-nor-dhea + Methyltestosterone Buccal

Methyltestosterone Buccal brand names: Oreton Buccal, Android 5.

Moderate Interaction
Medically reviewed by · Updated April 2025
The bottom line Moderate

19-nor-dhea has a moderate interaction with Methyltestosterone Buccal. 19-nor-DHEA is purportedly converted to nandrolone and other androgens upon ingestion.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

19-nor-dhea and Methyltestosterone Buccal

Here is the interaction we found between these two, with the evidence behind it.

Moderate

TESTOSTERONE

Why this applies to Methyltestosterone Buccal

Methyltestosterone Buccal falls under TESTOSTERONE — the group 19-nor-dhea interacts with.

19-nor-DHEA is purportedly converted to nandrolone and other androgens upon ingestion. Theoretically, taking 19-nor-DHEA with testosterone or other androgrens may increase the risk for additive adverse effects such as mood disturbances and cardiovascular, kidney, or liver problems.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: methyltestosterone (Oreton, Android) is already a powerful male hormone, and 19-nor-DHEA is sold as a 'prohormone' that your body may turn into nandrolone-like androgens. So you'd basically be stacking one strong hormone on top of another. This isn't about one blocking or speeding up the other. It's about the effects piling up on top of each other.

When androgens add up, you can see more of the usual concerns: mood swings or irritability, acne and oily skin, fluid retention, and strain on the liver, kidneys, and heart. Methyltestosterone is already known to be tough on the liver. This combo is a theoretical concern based on how these hormones work, not hard human studies, but the safe move is to talk with your doctor or pharmacist before pairing them.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

19-nor-dhea Also Interacts With Other Medications

19-nor-dhea has 7 moderate known drug interactions in our database — the Methyltestosterone Buccal one above is one of them. If you take anything else, check it against the full list below.

Moderate 7 No known interaction 2,823 (incl. Methyltestosterone Buccal)
Taking anything else?

Check Another of Your Medications Against 19-nor-dhea

Covers the 2,830 medications we’ve checked against 19-nor-dhea. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Methyltestosterone Buccal

This page covers 19-nor-dhea only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methyltestosterone Buccal page lists 73 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and 1-androsterone (moderate).

By severity: 4 major · 53 moderate · 16 minor.

From our pharmacist’s overview on the Methyltestosterone Buccal page

“Methyltestosterone buccal (Oreton Buccal, Android 5) is an androgen that can strain the liver on its own, and 38 of the 73 supplements on this list can add to that liver stress, so real care is warranted. Two of the four major entries are alcohol itself, beer and wine, since drinking on top of a liver-taxing drug raises the risk of dam…”

Reviewed by 2 · Jul 18, 2026

Open the Methyltestosterone Buccal interaction page

One more smart check

Taking 19-nor-dhea as Part of a Dietary Supplement Product? Check It for Interactions

We hold 12 real supplement products containing 19-nor-dhea, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 19-nor-dhea. Your product may carry other ingredients that interact with Methyltestosterone Buccal too, on top of 19-nor-dhea — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where 19-nor-dhea and Methyltestosterone Buccal Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 19-nor-dhea
Top half

#649 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methyltestosterone Buccal
Top half

#1,160 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About 19-nor-dhea

What is 19-nor-dhea?

  • Muscle building and bodybuilding
  • Increasing strength
  • Athletic performance
  • Supporting hormone levels
  • Body recomposition

19-nor-DHEA is a synthetic 'prohormone' marketed to bodybuilders as a precursor to nandrolone-like compounds, not a natural plant supplement. There is very little reliable human research on its safety or effectiveness, and products like it carry real risks to the liver, hormones, and heart. We do not recommend using it without close medical supervision, and it may be banned in sports and restricted by law in some places.

Read the full 19-nor-dhea monograph & all interactions
Keep checking

Other Drugs & 19-nor-dhea

Browse every other medication we’ve checked against 19-nor-dhea — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
7Moderate
0Minor
2,822No known interaction
7 Moderate 2,822 No interaction
Moderate

7 interactions

No interaction 2,822 drugs checked — show the list

We also checked 19-nor-dhea against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,822 medications checked with no known interaction — see the full 19-nor-dhea list.

See the full 19-nor-dhea interactions page
See every supplement checked against Methyltestosterone Buccal, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
19-nor-dhea monograph › Uses, safety, and every drug interaction in one place Methyltestosterone Buccal supplement interactions › Every supplement checked against Methyltestosterone Buccal, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking 19-nor-dhea and Methyltestosterone Buccal Together: Common Questions

Can you take 19-nor-dhea with Methyltestosterone Buccal?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the 19-nor-dhea and Methyltestosterone Buccal interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Methyltestosterone Buccal and 19-nor-dhea?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.