7,8-benzoflavone + Protriptyline
Protriptyline brand name: Vivactil.
We found no known interaction between 7,8-benzoflavone and Protriptyline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
7,8-benzoflavone and Protriptyline
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Protriptyline and 7,8-benzoflavone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for 7,8-benzoflavone at all — not against Protriptyline, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
7,8-benzoflavone safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
7,8-benzoflavone in Pregnancy & Breastfeeding
When used orally or parenterally. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing aromatase inhibitors are dangerous. Avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Questions About 7,8-benzoflavone or Protriptyline
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers 7,8-benzoflavone or Protriptyline, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Protriptyline
This page covers 7,8-benzoflavone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Protriptyline page lists 93 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Henbane (major), Lithium (major), Scopolia (major) and 5-htp (moderate).
By severity: 4 major · 71 moderate · 18 minor.
From our pharmacist’s overview on the Protriptyline page
“Protriptyline (Vivactil) is an older tricyclic antidepressant, and I read its supplement list with genuine care because so much of it piles onto what the drug already does. Four of the 93 ingredients on file rate major, and those deserve your attention before anything else.”
Reviewed by 2 · Jul 18, 2026
Where 7,8-benzoflavone and Protriptyline Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,402 of 1,452 supplements looked up here in the last 7 days
#1,670 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 7,8-benzoflavone reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The 7,8-benzoflavone and Protriptyline records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About 7,8-benzoflavone
What is 7,8-benzoflavone?
- Lowering estrogen levels
- Raising testosterone
- Reducing gynecomastia from anabolic steroids
- Bodybuilding and athletic performance
7,8-Benzoflavone (alpha-naphthoflavone) is a synthetic flavone studied mainly in laboratories for its effects on enzymes like aromatase and certain liver enzymes. It is not an approved or well-studied dietary supplement in humans, its safety is poorly defined, and aromatase inhibitors are banned in sports — so it should not be used without medical supervision.
Synthetic flavone compound (also studied as a plant flavonoid derivative) · Research chemical; sometimes found in bodybuilding or 'aromatase inhibitor' supplements
An interaction check asks whether these two react with each other — it does not ask whether 7,8-benzoflavone is a good idea for someone in your situation. Here is what our 7,8-benzoflavone record says about it on its own.
7,8-benzoflavone: dosing
There is no established or safe human dose for 7,8-benzoflavone. It is not an approved supplement or medicine, and reliable dosing information does not exist.We do not recommend taking it.
From our 7,8-benzoflavone monograph — the full record covers uses, side effects and every documented interaction.
About Protriptyline
What Is Protriptyline Used For?
Brand name: Vivactil
Protriptyline Hydrochloride tablets are used to treat symptoms of mental depression in patients who are under close medical supervision. Because it has activating (energizing) properties rather than sedating ones, it may be especially useful for people with depression who feel withdrawn or have very low energy.
Other Drugs & 7,8-benzoflavone
Browse every other medication we’ve checked against 7,8-benzoflavone — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked 7,8-benzoflavone against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Metoprolol ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full 7,8-benzoflavone list.
7,8-benzoflavone References
The 1 references that drive our 7,8-benzoflavone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Protriptyline Is Linked to Lower Levels of 3 Nutrients
Natural Medicines records Protriptyline as a medicine that can lower these. This is not an interaction with 7,8-benzoflavone — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Protriptyline nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking 7,8-benzoflavone and Protriptyline Together: Common Questions
Is it safe to take 7,8-benzoflavone with Protriptyline?
Does Protriptyline interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Protriptyline and 7,8-benzoflavone?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.