Drug & supplement interaction

Acupuncture + Omadacycline (Oral)

Omadacycline (Oral) brand name: Nuzyra.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Acupuncture and Omadacycline (Oral) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Acupuncture and Omadacycline (Oral)

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Omadacycline (Oral) and Acupuncture in our sources. This does not guarantee that the combination is completely free of risk — research on Acupuncture alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Acupuncture at all — not against Omadacycline (Oral), and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Acupuncture is a treatment rather than something you take. Tell whoever provides it which medicines you use, and ask your prescriber whether it is appropriate for your health and treatment. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Acupuncture safety at a glance

Acupuncture overall Use caution Generally safe when performed by a licensed practitioner with sterile, single-use needles.
Pregnancy Possibly Safe When used appropriately at most acupoints and performed with sterile needles. Some clinical research shows that acupuncture has been used during pregnancy and l... Read the full pregnancy detail
Breastfeeding Possibly Safe When used appropriately at most acupoints and performed with sterile needles. Some clinical research shows that acupuncture has been used during pregnancy and l... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Omadacycline (Oral) and Acupuncture? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Acupuncture and Omadacycline (Oral) May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so having Acupuncture while taking the medicine can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    Acupuncture

    “Minor pain, swelling, and bruising have been reported with acupuncture in clinical trials.

    Mishandling acupuncture needles can cause traumatic damage to the body. There have been case reports of epidural and subdural hematomas from improper acupuncture, resulting in paresthesia, hemiparesis, quadriparesis, and sensory deficit.”

    Acupuncture · Natural Medicines adverse-effect record, reported in back pain.

    6 sources cited
    1. 102626. Hou W, Pei L, Song Y, et al. Acupuncture therapy for breast cancer-related lymphedema: A systematic review and meta-analysis. J Obstet Gynaecol Res. 2019;45(12):2307-2317. PubMed
    2. 102627. Yu S, Zhu L, Xie P, et al. Effects of acupuncture on breast cancer-related lymphoedema: A systematic review and meta-analysis. Explore (NY). 2020;16(2):97-102. PubMed
    3. 102628. He Y, Guo X, May BH, et al. Clinical evidence for association of acupuncture and acupressure with improved cancer pain: A systematic review and meta-analysis. JAMA Oncol. 2019;6(2):271-8. PubMed
    4. 102636. Hwang MS, Lee HY, Choi TY, et al. A systematic review and meta-analysis of the efficacy of acupuncture and electroacupuncture against chemotherapy-induced peripheral neuropathy. Medicine (Baltimore). 2020;99(17):e19837. PubMed
    5. 102638. Wang L, Xu J, Zhan Y, Pei J. Acupuncture for obstructive sleep apnea (OSA) in adults: A systematic review and meta-analysis. Biomed Res Int. 2020;2020:6972327. PubMed
    6. 102640. Zhang J, Liu Y, Huang X, et al. Efficacy comparison of different acupuncture treatments for functional dyspepsia: A systematic review with network meta-analysis. Evid Based Complement Alternat Med. 2020;2020:3872919. PubMed

    “Nonsterile conditions during acupuncture or the use of nonsterile acupuncture needles can lead to infection. There have been case reports of mycobacterial infection, hepatitis B, necrotizing fasciitis, fatal acute peritonitis, fungal spinal infection, bilateral facet joint septic arthritis, skin infections with gordonia species, and subcutaneous or paravertebral abscesses following treatments which included acupunctu…”

    Acupuncture · Natural Medicines adverse-effect record, reported in hepatitis.

    6 sources cited
    1. 101374. Choi ME, Jung CJ, Won CH, et al. Case report of cutaneous nodule caused by Gordonia bronchialis in an immunocompetent patient after receiving acupuncture. J Dermatol. 2019;46(4):343-346.
    2. 101383. Glas AW, Jüttner AM, Kooter AJ. Necrotising fasciitis after acupuncture treatment in an immunocompetent patient. BMJ Case Rep. 2016;2016. pii: bcr2016216405. PubMed
    3. 101389. Kim D, Lee S. An autopsy case of fatal acute peritonitis complicated by illegal acupuncture therapy. Forensic Sci Int. 2017;276:e13-e15. PubMed
    4. 114215. Hyun MH, Kim JH, Jang JW, et al. Risk of Hepatitis C Virus Transmission through acupuncture: A systematic review and meta-analysis. Korean J Gastroenterol 2023;82(3):127-136. PubMed
    5. 114257. Yuan J, Goh AGW, Mohamed Shah MTB. Bilateral facet joint septic arthritis induced by acupuncture: A case report highlighting diagnostic challenges and the importance of early intervention. Am J Case Rep 2024;25:e944596. PubMed
    6. 114260. Yang R, Hu Y, Liu S, Wang H. Subcutaneous and paravertebral abscess following massage and acupuncture with cupping: A case report and literature review. Asian J Surg. 2024 Jun;47(6):2632-2634. doi: 10.1016/j.asjsur.2023.08.210. Epub 2023 Sep 7. PubMed

    Omadacycline (Oral)

    Listed in the ADVERSE REACTIONS section of the FDA label for Omadacycline (Oral). Read the label on DailyMed ›

  • A higher chance of infection Worth acting on Additional detail

    Acupuncture

    “Acupuncture, when used appropriately, is generally well-tolerated.

    Most Common Adverse Effects:

    Bruising, pain, and swelling.

    Serious Adverse Effects (Rare):

    Some case reports raise concerns about acute respiratory failure, circulatory failure, hemothorax, infection at the needle site, pneumocranium, pneumothorax, kidney laceration, and death.”

    Acupuncture · Natural Medicines adverse-effect record, reported in pain.

    Omadacycline (Oral)

    Listed in the ADVERSE REACTIONS section of the FDA label for Omadacycline (Oral). Read the label on DailyMed ›

  • Nausea Additional detail

    Acupuncture

    “Nausea, gastrointestinal discomfort, and constipation have been reported rarely.”

    Acupuncture · Natural Medicines adverse-effect record, reported in constipation.

    6 sources cited
    1. 103432. Qin X, Coyle ME, Yang L, et al. Acupuncture for recurrent urinary tract infection in women: a systematic review and meta-analysis. BJOG. 2020.
    2. 103435. Fan SQ, Jin S, Tang TC, Chen M, Zheng H. Efficacy of acupuncture for migraine prophylaxis: a trial sequential meta-analysis. J Neurol. 2020. PubMed
    3. 105403. Jang A, Brown C, Lamoury G, et al. The effects of acupuncture on cancer-related fatigue: updated systematic review and meta-analysis. Integr Cancer Ther. 2020;19:1534735420949679. PubMed
    4. 109836. Zhu C, Xia W, Huang J, et al. Effects of acupuncture on the pregnancy outcomes of frozen-thawed embryo transfer: A systematic review and meta-analysis. Front Public Health 2022;10:987276. PubMed
    5. 111838. Pang J, Shergis JL, Zheng L, et al. Clinical evidence for acupuncture for adult asthma: Systematic review and meta-analysis of randomised sham/placebo-controlled trials. Complement Ther Med 2023;75:102956. PubMed
    6. 114228. Lin J, Kong Y, Chen H, Ding X, Zhou W. Effects of acupuncture on sleep quality in patients with Parkinson's disease: A systematic review and meta-analysis. Clin Rehabil 2024;38(4):478-496. PubMed

    Omadacycline (Oral)

    Listed in the ADVERSE REACTIONS section of the FDA label for Omadacycline (Oral). Read the label on DailyMed ›

Reported for Acupuncture but not commonly for Omadacycline (Oral): stomach upset, back pain, constipation and mood changes or irritability.

Effects for Omadacycline (Oral) come from the ADVERSE REACTIONS section of its FDA label; effects for Acupuncture come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Acupuncture in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Safe

When used appropriately at most acupoints and performed with sterile needles. Some clinical research shows that acupuncture has been used during pregnancy and labor without reports of significant adverse effects. POSSIBLY UNSAFE...when acupuncture at the SP6 acupoint is used. There is some concern that this acupoint can increase the risk of early contractions and miscarriage. Most evidence also suggests that acupuncture is safe for patients undergoing in vitro fertilization (IVF). One large clinical study and a meta-analysis show that receiving acupuncture one or more times between follicle stimulation and pregnancy testing does not affect the pregnancy or live birth rate when compared with sham acupuncture or no intervention. However, a smaller study shows that acupuncture performed off-site immediately before and after IVF embryo transfer reduces the pregnancy rate by 21% when compared to no additional intervention. Use caution until more is known about the safety of acupuncture during IVF. There is insufficient reliable information available about the use of electroacupuncture or laser acupuncture during pregnancy; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Omadacycline (Oral)

This page covers Acupuncture only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Omadacycline (Oral) page lists 41 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Oleander (major), Black Hellebore (moderate), Calcium (moderate) and Coffee Charcoal (moderate).

By severity: 2 major · 29 moderate · 10 minor.

From our pharmacist’s overview on the Omadacycline (Oral) page

“Omadacycline (Nuzyra) is a tetracycline-class antibiotic, and its list of 41 interacting supplements calls for real care rather than a quick skim. Two entries rate major and deserve to be understood first.”

Reviewed by 2 · Jul 18, 2026

Open the Omadacycline (Oral) interaction page

How much people look this up

Where Acupuncture and Omadacycline (Oral) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Acupuncture
Steady interest

#1,180 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Omadacycline (Oral)
Steady interest

#1,979 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Acupuncture reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Acupuncture and Omadacycline (Oral) records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Treatment approach

About Acupuncture

What is Acupuncture?

  • Chronic pain
  • Low back and neck pain
  • Osteoarthritis (especially knee)
  • Headache and migraine
  • Nausea and vomiting
  • Stress and well-being

Acupuncture is a traditional Chinese medicine practice that involves inserting thin needles into specific points on the body. There is moderate evidence it may help certain types of chronic pain and nausea, while evidence for many other uses is weak or unclear. When done by a licensed, trained practitioner using sterile, single-use needles, it is generally considered safe for most people.

Not applicable (a physical therapy, not an herb or supplement) · Manual needling, electroacupuncture, ear (auricular) acupuncture, acupressure, laser acupuncture

An interaction check asks whether these two react with each other — it does not ask whether Acupuncture is a good idea for someone in your situation. Here is what our Acupuncture record says about it on its own.

Acupuncture: dosing

There is no standard "dose" for acupuncture the way there is for a pill. Treatment plans differ by practitioner and condition. If you are not seeing benefit after a reasonable trial, discuss whether to continue.

From our Acupuncture monograph — the full record covers uses, side effects and every documented interaction.

Read the full Acupuncture monograph & all interactions
Medication

About Omadacycline Injection

What Is Omadacycline Injection Used For?

Brand name: Nuzyra

Nuzyra (omadacycline) injection is used in adults to treat two types of serious bacterial infections: community-acquired bacterial pneumonia (CABP) — a lung infection picked up outside of a hospital — and acute bacterial skin and skin structure infections (ABSSSI), which include serious skin infections such as those caused by MRSA (methicillin-resistant Staphylococcus aureus).

Nuzyra works only against bacterial infections. It is not effective against viral illnesses like the flu or common cold. Your doctor will prescribe it only when a bacterial infection is confirmed or strongly suspected, to help prevent the growth of antibiotic-resistant bacteria.

See full Omadacycline Injection drug information
Keep checking

Other Drugs & Acupuncture

Browse every other medication we’ve checked against Acupuncture — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Acupuncture References

The 99 references that drive our Acupuncture monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Smith CA, Collins CT, Cyna AM, Crowther CA. Complementary and alternative therapies for pain management in labour. Cochrane Database Syst Rev 2006;(4):CD003521. PubMed
  2. Smith, C., Crowther, C., and Beilby, J. Acupuncture to treat nausea and vomiting in early pregnancy: a randomized controlled trial. Birth 2002;29(1):1-9. PubMed
  3. Helmreich, R. J., Shiao, S. Y., and Dune, L. S. Meta-analysis of acustimulation effects on nausea and vomiting in pregnant women. Explore (NY) 2006;2(5):412-421. PubMed
  4. Carlsson, C. P., Axemo, P., Bodin, A., Carstensen, H., Ehrenroth, B., Madegard-Lind, I., and Navander, C. Manual acupuncture reduces hyperemesis gravidarum: a placebo- controlled, randomized, single-blind, crossover study. J Pain Symptom Manage 2000;20(4) PubMed
  5. Habek, D., Barbir, A., Habek, J. C., Janculiak, D., and Bobic-Vukovic, M. Success of acupuncture and acupressure of the Pc 6 acupoint in the treatment of hyperemesis gravidarum. Forsch Komplementarmed Klass Naturheilkd 2004;11(1):20-23. PubMed
  6. Guerreiro da Silva, J. B., Nakamura, M. U., Cordeiro, J. A., and Kulay, L., Jr. Acupuncture for low back pain in pregnancy--a prospective, quasi-randomised, controlled study. Acupunct Med 2004;22(2):60-67. PubMed
  7. Hantoushzadeh, S., Alhusseini, N., and Lebaschi, A. H. The effects of acupuncture during labour on nulliparous women: a randomised controlled trial. Aust N Z J Obstet Gynaecol 2007;47(1):26-30. PubMed
  8. Selmer-Olsen, T., Lydersen, S., and Morkved, S. Does acupuncture used in nulliparous women reduce time from prelabour rupture of membranes at term to active phase of labour? A randomised controlled trial. Acta Obstet Gynecol Scand 2007;86(12):1447-1452. PubMed
  9. Craig LB, Rubin LE, Peck JD, Anderson M, Marshall LA, Soules MR. Acupuncture performed before and after embryo transfer: a randomized controlled trial. J Reprod Med. 2014;59(5-6):313-20.
  10. Smith CA, de Lacey S, Chapman M, et al. Effect of Acupuncture vs Sham Acupuncture on Live Births Among Women Undergoing In Vitro Fertilization: A Randomized Clinical Trial. JAMA. 2018;319(19):1990-1998. PubMed
  11. Choi ME, Jung CJ, Won CH, et al. Case report of cutaneous nodule caused by Gordonia bronchialis in an immunocompetent patient after receiving acupuncture. J Dermatol. 2019;46(4):343-346.
  12. Domenicucci M, Marruzzo D, Pesce A, Raco A, Missori P. Acute Spinal Epidural Hematoma After Acupuncture: Personal Case and Literature Review. World Neurosurg. 2017;102:695.e11-695.e14. PubMed
  13. Eghbal K, Ghaffarpasand F. An Acute Cervical Subdural Hematoma as the Complication of Acupuncture: Case Report and Literature Review. World Neurosurg. 2016 Nov;95:616.e11-616.e13. PubMed
  14. Glas AW, Jüttner AM, Kooter AJ. Necrotising fasciitis after acupuncture treatment in an immunocompetent patient. BMJ Case Rep. 2016;2016. pii: bcr2016216405. PubMed
  15. Jian J, Shao Y, Wan L, et al. Autopsy diagnosis of acupuncture-induced bilateral tension pneumothorax using whole-body postmortem computed tomography: A case report. Medicine (Baltimore). 2018;97(44):e13059. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Having Acupuncture While Taking Omadacycline (Oral): Common Questions

Is it safe to have Acupuncture while taking Omadacycline (Oral)?
We do not list a known interaction between Acupuncture and Omadacycline (Oral). That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Acupuncture and Omadacycline (Oral) have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Omadacycline (Oral) interact with any supplements?
Yes. Omadacycline (Oral) has documented interactions with 41 supplements in our database — Acupuncture is not one of them. The Omadacycline (Oral) interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Omadacycline (Oral) and Acupuncture?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.