Medication interaction hub

What Supplements Interact with Omadacycline (Oral)?

Omadacycline (Oral) brand name: Nuzyra. Every interaction below applies to the brands too.

41 Interactions 2 Major 29 Moderate 10 Minor
Curated & coded by · Clinical Pharmacist · Updated October 1, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Omadacycline (Oral)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Omadacycline (Oral) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Omadacycline (Nuzyra) is a tetracycline-class antibiotic, and its list of 41 interacting supplements calls for real care rather than a quick skim. Two entries rate major and deserve to be understood first. Activated charcoal can soak up the drug in the gut and gut the antibiotic effect of a whole course, and oleander is dangerous the other way, since tetracyclines can raise levels of its heart-active compounds toward toxicity. A handful of other plants, foxglove and lily-of-the-valley among them, carry the same glycoside concern at a moderate rating.

Most of the 29 moderate entries come down to one mechanism, minerals binding the antibiotic before it can be absorbed. Calcium, iron, magnesium, zinc, even yogurt and whey protein can slash how much drug reaches your blood, iron by as much as 50 to 90 percent, and with an antibiotic that risks treatment failure. Space these well apart from your dose and check each entry below for the specific gap. Ten minor entries round out the list.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 29 Minor 10 No known interaction 1,411

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Omadacycline (Oral): Top Interactions at a Glance

The most significant Omadacycline (Oral) supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 41 interacting ingredients — plus 1,411 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Omadacycline (Oral) + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Activated Charcoal + Omadacycline (Oral)i

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Oleander + Omadacycline (Oral)i

Theoretically, tetracycline antibiotics may increase the risk of oleander toxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Omadacycline (Oral)

All 1,452 ingredients in our database, ranked by severity — 41 with a Omadacycline (Oral) interaction on file and 1,411 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Omadacycline (Oral)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bromelain with Omadacycline (Oral)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, bromelain might increase levels of tetracycline antibiotics.

Full Bromelain + Omadacycline (Oral) answer

Can you take Riboflavin with Omadacycline (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.

Full Riboflavin + Omadacycline (Oral) answer

Can you take Activated Charcoal with Omadacycline (Oral)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Omadacycline (Oral) answer

Can you take Oleander with Omadacycline (Oral)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Theoretically, tetracycline antibiotics may increase the risk of oleander toxicity.

Full Oleander + Omadacycline (Oral) answer

Can you take Calcium with Omadacycline (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Calcium seems to reduce the absorption of tetracycline antibiotics.

Full Calcium + Omadacycline (Oral) answer

Can you take Coffee Charcoal with Omadacycline (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Omadacycline (Oral) answer

Can you take Dolomite with Omadacycline (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, the calcium and magnesium in dolomite might decrease the absorption of tetracycline antibiotics.

Full Dolomite + Omadacycline (Oral) answer

Can you take European Mandrake with Omadacycline (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Omadacycline (Oral) answer

Can you take Glucomannan with Omadacycline (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Omadacycline (Oral) answer

Can you take Iron with Omadacycline (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Iron might decrease levels of tetracycline antibiotics by reducing their absorption.

Full Iron + Omadacycline (Oral) answer

Can you take Magnesium with Omadacycline (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Magnesium decreases absorption of tetracyclines.

Full Magnesium + Omadacycline (Oral) answer

Can you take Manganese with Omadacycline (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, manganese might reduce the absorption of tetracycline antibiotics.

Full Manganese + Omadacycline (Oral) answer

Can you take Strontium with Omadacycline (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, strontium might decrease the absorption of tetracycline antibiotics.

Full Strontium + Omadacycline (Oral) answer

Can you take Whey Protein with Omadacycline (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, whey protein might decrease tetracycline absorption.

Full Whey Protein + Omadacycline (Oral) answer

Can you take Yogurt with Omadacycline (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking yogurt with tetracycline antibiotics seems to reduce the levels and clinical effects of tetracycline antibiotics.

Full Yogurt + Omadacycline (Oral) answer

Can you take Zinc with Omadacycline (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Zinc might reduce levels of tetracycline antibiotics.

Full Zinc + Omadacycline (Oral) answer

Can you take Black Hellebore with Omadacycline (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of tetracyclic antibiotics and black hellebore might increase the risk of cardiac glycoside toxicity.

Full Black Hellebore + Omadacycline (Oral) answer

Can you take Foxglove with Omadacycline (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of quinine increases the risk of cardiac glycoside toxicity.

Full Foxglove + Omadacycline (Oral) answer

Can you take Guar Gum with Omadacycline (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Omadacycline (Oral) answer

Can you take Gum Arabic with Omadacycline (Oral)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Omadacycline (Oral) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Omadacycline (Oral) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Omadacycline (Oral), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Omadacycline (Oral) sits in 2 interaction categories. Open any one to see what the group means:

Tetracycline Antibiotics 24 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

24 of the supplement ingredients on this page reach Omadacycline (Oral) through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Omadacycline (Oral) through this category.

About Omadacycline (Oral)

Omadacycline Injection (Nuzyra) is an intravenous tetracycline-class antibiotic for adults with community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections.

Generic name: Omadacycline (Oral)  ·  Brand name: Nuzyra.

See the full Omadacycline Injection drug information

Related: does Omadacycline (Oral) deplete any nutrients?

Omadacycline (Oral) has 4 reported nutrient associations in the research literature — see the Omadacycline (Oral) nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Omadacycline (Oral)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Omadacycline (Oral).

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Pharmacist Counseling Corner

Omadacycline (Oral) & Supplements: Common Questions

What supplements interact with Omadacycline (Oral)?
In our interaction database, 41 supplement and herbal ingredients have an interaction with Omadacycline (Oral) on file — 2 rated major, 29 moderate, and 10 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Oleander, Calcium.
Which Omadacycline (Oral) supplement interactions are the most serious?
Focus on the major group: Activated Charcoal and Oleander. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Omadacycline (Oral)?
That depends entirely on which supplement. The honest answer for Omadacycline (Oral) is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Nuzyra have the same supplement interactions as Omadacycline (Oral)?
Yes — Nuzyra all contain Omadacycline (Oral), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Omadacycline (Oral) deplete any vitamins or nutrients?
It might — Omadacycline (Oral) has 4 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Omadacycline (Oral) nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Omadacycline (Oral) and my other medications?
This page covers Omadacycline (Oral) against supplements and herbal ingredients. Checking Omadacycline (Oral) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Omadacycline Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 1, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.