Yogurt + Omadacycline (Oral)
Omadacycline (Oral) brand name: Nuzyra.
Yogurt has a moderate interaction with Omadacycline (Oral). Taking yogurt with tetracycline antibiotics seems to reduce the levels and clinical effects of tetracycline antibiotics.
Read the full interaction reportYogurt and Omadacycline (Oral)
Here is the interaction we found between these two, with the evidence behind it.
TETRACYCLINE ANTIBIOTICS
Why this applies to Omadacycline (Oral)
Omadacycline (Oral) falls under TETRACYCLINE ANTIBIOTICS — the group Yogurt interacts with.
Concomitant administration with yogurt can reduce the absorption of tetracycline antibiotics, likely due to its calcium content.
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
Here's the thing with oral omadacycline (Nuzyra): like other tetracycline antibiotics, it can grab onto calcium and other minerals in your gut. Yogurt is rich in calcium, so eating it close to your dose may bind up some of the drug before your body can absorb it. That can leave less antibiotic in your system to fight the infection.
If too little gets absorbed, the worry is that your infection (such as pneumonia or a skin infection) may not clear as well as it should. This concern is based on how the drug behaves chemically rather than hard clinical studies, so it's more theoretical than proven. To be safe, separate yogurt and other dairy from your dose, and ask your pharmacist exactly how many hours apart to space them.
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Yogurt Also Interacts With Other Medications
Yogurt has 20 moderate, 1 minor known drug interactions in our database — the Omadacycline (Oral) one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Yogurt
We haven’t checked that one against Yogurt yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Yogurt. Pick one to open its full report.
See Every Supplement That Interacts With Omadacycline (Oral)
This page covers Yogurt only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Omadacycline (Oral) page lists 41 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Oleander (major), Black Hellebore (moderate), Calcium (moderate) and Coffee Charcoal (moderate).
By severity: 2 major · 29 moderate · 10 minor.
From our pharmacist’s overview on the Omadacycline (Oral) page
“Omadacycline (Nuzyra) is a tetracycline-class antibiotic, and its list of 41 interacting supplements calls for real care rather than a quick skim. Two entries rate major and deserve to be understood first.”
Reviewed by 2 · Jul 18, 2026
Taking Yogurt as Part of a Dietary Supplement Product? Check It for Interactions
We hold 45 real supplement products containing Yogurt, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Yogurt. Your product may carry other ingredients that interact with Omadacycline (Oral) too, on top of Yogurt — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Yogurt and Omadacycline (Oral) Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,072 of 1,452 supplements looked up here in the last 7 days
#2,018 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Yogurt
What is Yogurt?
- Digestive health
- Restoring gut bacteria after antibiotics
- Vaginal yeast or bacterial balance
- Source of protein and calcium
- General immune and gut support
Yogurt is a fermented dairy food that often contains live bacteria (probiotics) and provides protein, calcium, and other nutrients. For most healthy people it is a safe, nutritious food, and some yogurts with live cultures may help with digestion and gut balance, though evidence varies by strain and condition. If you are lactose intolerant, have a milk allergy, or have a weakened immune system, talk to your pharmacist or doctor first.
About Omadacycline Injection
What Is Omadacycline Injection Used For?
Brand name: Nuzyra
Nuzyra (omadacycline) injection is used in adults to treat two types of serious bacterial infections: community-acquired bacterial pneumonia (CABP) — a lung infection picked up outside of a hospital — and acute bacterial skin and skin structure infections (ABSSSI), which include serious skin infections such as those caused by MRSA (methicillin-resistant Staphylococcus aureus).
Nuzyra works only against bacterial infections. It is not effective against viral illnesses like the flu or common cold. Your doctor will prescribe it only when a bacterial infection is confirmed or strongly suspected, to help prevent the growth of antibiotic-resistant bacteria.
Other Drugs & Yogurt
Browse every other medication we’ve checked against Yogurt — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
20 interactions
- Doxycycline ›
- Minocycline ›
- Tetracycline ›
- Ciprofloxacin ›
- Doxycycline Hyclate ›
- Minocycline Hydrochloride ›
- Retapamulin ›
- Chlortetracycline ›
- Demeclocycline ›
- Doripenem ›
- Doxycycline Monohydrate ›
- Doxycyline ›
- Eravacycline ›
- Omadacycline (iv) ›
- Oxytetracycline ›
- Tigecycline ›
- Amphotericin, Tetracycline ›
- Bismuth Subsalicylate, Metronidazole, Tetracycline ›
- Metronidazole, Tetracyline, Bismuth Subcitrate Potassium ›
- Oxytetracycline, Phenazopyridine, Sulfamethizole ›
1 interaction
No interaction 2,808 drugs checked — show the list
We also checked Yogurt against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Rivaroxaban ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Tadalafil ›
- Clopidogrel ›
- Abemaciclib ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Valacyclovir ›
- Ibuprofen ›
- Tirzepatide ›
- Methamphetamine ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Bendamustine ›
- Amitriptyline ›
- Acyclovir ›
- Methotrexate ›
- Fluoxetine ›
- Amphetamine ›
- Lamotrigine ›
- Pregabalin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Gabapentin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Amlodipine Besylate ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
Showing the 60 most looked-up of 2,808 medications checked with no known interaction — see the full Yogurt list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Omadacycline (Oral) Is Linked to Lower Levels of 4 Nutrients
Natural Medicines records Omadacycline (Oral) as a medicine that can lower these. This is not an interaction with Yogurt — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Omadacycline (Oral) nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Yogurt and Omadacycline (Oral) Together: Common Questions
Can you take Yogurt with Omadacycline (Oral)?
How serious is the Yogurt and Omadacycline (Oral) interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.