Drug & supplement interaction

Yogurt + Chlortetracycline

Chlortetracycline brand name: Aureomycin.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Yogurt has a moderate interaction with Chlortetracycline. Taking yogurt with tetracycline antibiotics seems to reduce the levels and clinical effects of tetracycline antibiotics.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Yogurt and Chlortetracycline

Here is the interaction we found between these two, with the evidence behind it.

Moderate

TETRACYCLINE ANTIBIOTICS

Why this applies to Chlortetracycline

Chlortetracycline falls under TETRACYCLINE ANTIBIOTICS — the group Yogurt interacts with.

Taking yogurt with tetracycline antibiotics seems to reduce the levels and clinical effects of tetracycline antibiotics.
Concomitant administration with yogurt can reduce the absorption of tetracycline antibiotics, likely due to its calcium content.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: yogurt is rich in calcium, and calcium loves to grab onto chlortetracycline in your stomach. When that happens, the two bind together and your body can't absorb the antibiotic as well. The result isn't more side effects, it's actually the opposite problem, you may get less of the drug into your bloodstream, which can make it work poorly against your infection.

This is based on how the chemistry works rather than big clinical studies, but it's a well-accepted concern with all tetracyclines. A practical fix many pharmacists suggest is simply spacing them out, taking your chlortetracycline a couple of hours away from yogurt or other dairy. Check the exact timing with your pharmacist so your treatment stays effective.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Yogurt Also Interacts With Other Medications

Yogurt has 20 moderate, 1 minor known drug interactions in our database — the Chlortetracycline one above is one of them. If you take anything else, check it against the full list below.

Moderate 20 Minor 1 No known interaction 2,809 (incl. Chlortetracycline)
Taking anything else?

Check Another of Your Medications Against Yogurt

Covers the 2,830 medications we’ve checked against Yogurt. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Chlortetracycline

This page covers Yogurt only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Chlortetracycline page lists 161 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Oleander (major) and Siberian Cocklebur (major).

By severity: 7 major · 134 moderate · 20 minor.

Open the Chlortetracycline interaction page

One more smart check

Taking Yogurt as Part of a Dietary Supplement Product? Check It for Interactions

We hold 45 real supplement products containing Yogurt, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Yogurt. Your product may carry other ingredients that interact with Chlortetracycline too, on top of Yogurt — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Yogurt and Chlortetracycline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Yogurt
Steady interest

#1,062 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Chlortetracycline
Steady interest

#2,194 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Yogurt

What is Yogurt?

  • Digestive health
  • Restoring gut bacteria after antibiotics
  • Vaginal yeast or bacterial balance
  • Source of protein and calcium
  • General immune and gut support

Yogurt is a fermented dairy food that often contains live bacteria (probiotics) and provides protein, calcium, and other nutrients. For most healthy people it is a safe, nutritious food, and some yogurts with live cultures may help with digestion and gut balance, though evidence varies by strain and condition. If you are lactose intolerant, have a milk allergy, or have a weakened immune system, talk to your pharmacist or doctor first.

Read the full Yogurt monograph & all interactions
Keep checking

Other Drugs & Yogurt

Browse every other medication we’ve checked against Yogurt — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
20Moderate
1Minor
2,808No known interaction
20 Moderate 1 Minor 2,808 No interaction
Moderate

20 interactions

Minor

1 interaction

No interaction 2,808 drugs checked — show the list

We also checked Yogurt against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,808 medications checked with no known interaction — see the full Yogurt list.

See the full Yogurt interactions page
See every supplement checked against Chlortetracycline, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
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Pharmacist Counseling Corner

Taking Yogurt and Chlortetracycline Together: Common Questions

Can you take Yogurt with Chlortetracycline?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Yogurt and Chlortetracycline interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Chlortetracycline and Yogurt?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.