Drug & supplement interaction

Ajuga Nipponensis + Tasimelteon

Tasimelteon brand names: Hetlioz, Hetlioz Lq.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Ajuga Nipponensis and Tasimelteon in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tasimelteon states a food rule worth keeping to.

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Interaction report

Ajuga Nipponensis and Tasimelteon

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tasimelteon and Ajuga Nipponensis in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Ajuga Nipponensis at all — not against Tasimelteon, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ajuga Nipponensis safety at a glance

Ajuga Nipponensis overall Not established There is not enough reliable human data to judge its safety.
Pregnancy Avoid Safety has not been studied, so it is best avoided during pregnancy.
Breastfeeding Avoid No safety data exists for breastfeeding, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tasimelteon and Ajuga Nipponensis? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Ajuga Nipponensis Itself Has Been Linked To

This is not an interaction — nothing below involves Tasimelteon. It is the side-effect record for Ajuga Nipponensis on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Ajuga Nipponensis, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on Additional detail

    “Orally, Ajuga nipponensis has been reported to cause acute renal failure. An adult male with pre-existing liver cirrhosis developed acute renal failure after ingesting approximately 45 grams of whole Ajuga nipponensis.”

    Ajuga Nipponensis · Natural Medicines adverse-effect record, reported in cirrhosis.

    1 source cited
    1. 14070. Liao SC, Chiu TF, Chen JC, Lin CC. Ajuga nipponensis Makino poisoning. Clin Toxicol (Phila) 2005;43:583-5.
  • Diarrhea / Vomiting / Nausea Additional detail

    “Orally, Ajuga nipponensis has been reported to cause diarrhea, nausea, and vomiting.”

    Ajuga Nipponensis · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 14070. Liao SC, Chiu TF, Chen JC, Lin CC. Ajuga nipponensis Makino poisoning. Clin Toxicol (Phila) 2005;43:583-5.

Everything above comes from the Natural Medicines adverse-effect record for Ajuga Nipponensis — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Tasimelteon’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Tasimelteon column appears here.

How to take them

Some Tasimelteon Products Have a Food Rule — Ajuga Nipponensis Should Not Break It

At least one FDA label for a product containing Tasimelteon says to take it on an empty stomach. Most supplements — Ajuga Nipponensis included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Tasimelteon on its own and move Ajuga Nipponensis to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tasimelteon products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Indicated Population Dosage Form Body Weight Recommended Dosage Non-24 ( 2.2 ) Adults Capsules Not applicable 20 mg one hour prior to bedtime Nighttime sleep disturbances in SMS ( 2.3 ) Patients 16 years of age and older Capsules Not applicable 20 mg one hour prior to bedtime Pediatric Patients 3 to 15 years of age Oral Suspension ≤ 28 kg 0.7 mg/kg one hour before bedti

From the Dosage and Administration section of the FDA label we read for Tasimelteon — where that label names a specific product, the instruction is that product's. See the Tasimelteon drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Tasimelteon

This page covers Ajuga Nipponensis only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tasimelteon page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 166 moderate · 43 minor.

From our pharmacist’s overview on the Tasimelteon page

“Tasimelteon (Hetlioz) resets the body clock in people with non-24-hour sleep-wake disorder, and the sleep aids they often reach for, melatonin and kava among them, sit on an interaction list that deserves real respect. Nine of the 218 ingredients on file rate major, mostly in two directions: sedatives like kava stack drowsiness onto a…”

Reviewed by 2 · Jul 18, 2026

Open the Tasimelteon interaction page

How much people look this up

Where Ajuga Nipponensis and Tasimelteon Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ajuga Nipponensis
Steady interest

#1,297 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tasimelteon
Steady interest

#1,943 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ajuga Nipponensis reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Ajuga Nipponensis and Tasimelteon records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ajuga Nipponensis

What is Ajuga Nipponensis?

Ajuga Nipponensis
  • Cough and respiratory symptoms
  • Sore throat
  • Fever
  • Inflammation
  • Traditional general wellness

Ajuga nipponensis is a perennial plant from East Asia used in traditional medicine for cough and respiratory complaints. There is very little human research to confirm any health benefits, so its effectiveness and safety remain largely unknown. Talk to a pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or taking other medicines.

Ajuga nipponensis · Lamiaceae · Whole plant, leaves, and aerial parts · Dried herb, tea, traditional decoctions, extracts

An interaction check asks whether these two react with each other — it does not ask whether Ajuga Nipponensis is a good idea for someone in your situation. Here is what our Ajuga Nipponensis record says about it on its own.

Ajuga Nipponensis: dosing

There is no established or standardized dose for Ajuga nipponensis. Scientists have not determined a safe and effective amount for any condition.If you choose to use a product that contains it, follow the directions on the label and do not exceed them.

From our Ajuga Nipponensis monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ajuga Nipponensis monograph & all interactions
Medication

About Tasimelteon

What Is Tasimelteon Used For?

Brand names: Hetlioz, Hetlioz Lq

Tasimelteon capsules are approved to treat Non-24-Hour Sleep-Wake Disorder (Non-24) in adults. Non-24 is a condition where the body's internal clock does not align with the normal 24-hour day, causing sleep and wake times to shift continuously.

Hetlioz capsules are also approved to treat nighttime sleep disturbances in Smith-Magenis Syndrome (SMS) in patients 16 years of age and older. Hetlioz LQ oral suspension is approved specifically for nighttime sleep disturbances in SMS in pediatric patients ages 3 to 15 years.

Most-Reported Side Effects for Tasimelteon

From FAERS, the FDA’s public side-effect reporting system (5,770 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Insomnia 728 reports
Middle insomnia 414 reports
Somnolence 408 reports
Headache 386 reports
Nightmare 268 reports
See full Tasimelteon drug information
Keep checking

Other Drugs & Ajuga Nipponensis

Browse every other medication we’ve checked against Ajuga Nipponensis — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Ajuga Nipponensis References

The 1 references that drive our Ajuga Nipponensis monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Liao SC, Chiu TF, Chen JC, Lin CC. Ajuga nipponensis Makino poisoning. Clin Toxicol (Phila) 2005;43:583-5.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ajuga Nipponensis and Tasimelteon Together: Common Questions

Is it safe to take Ajuga Nipponensis with Tasimelteon?
We do not list a known interaction between Ajuga Nipponensis and Tasimelteon. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Ajuga Nipponensis and Tasimelteon at the same time of day?
At least one FDA label for a product containing Tasimelteon says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Tasimelteon on its own and move Ajuga Nipponensis to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
Does Tasimelteon interact with any supplements?
Yes. Tasimelteon has documented interactions with 218 supplements in our database — Ajuga Nipponensis is not one of them. The Tasimelteon interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Tasimelteon and Ajuga Nipponensis?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.