Alpha-alanine + Sofosbuvir, Velpatasvir, Voxilaprevir
Sofosbuvir, Velpatasvir, Voxilaprevir brand name: Vosevi.
We found no known interaction between Alpha-alanine and Sofosbuvir, Velpatasvir, Voxilaprevir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sofosbuvir, Velpatasvir, Voxilaprevir states a food rule worth keeping to.
Alpha-alanine and Sofosbuvir, Velpatasvir, Voxilaprevir
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Sofosbuvir, Velpatasvir, Voxilaprevir and Alpha-alanine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Alpha-alanine at all — not against Sofosbuvir, Velpatasvir, Voxilaprevir, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Alpha-alanine safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Alpha-alanine in Pregnancy & Breastfeeding
When used in amounts commonly found in foods. There is insufficient reliable information available about the safety of using larger amounts as medicine during pregnancy or lactation.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Sofosbuvir, Velpatasvir, Voxilaprevir Products Have a Food Rule — Alpha-alanine Should Not Break It
At least one FDA label for a product containing Sofosbuvir, Velpatasvir, Voxilaprevir says to take it with food. If you take Alpha-alanine on an empty stomach out of habit, keep them separate — and take Sofosbuvir, Velpatasvir, Voxilaprevir with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sofosbuvir, Velpatasvir, Voxilaprevir products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
( 2.1 ) Recommended dosage: One tablet (400 mg of sofosbuvir, 100 mg of velpatasvir, and 100 mg of voxilaprevir) taken orally once daily with food.
From the Dosage and Administration section of the FDA label we read for Sofosbuvir, Velpatasvir, Voxilaprevir — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Sofosbuvir, Velpatasvir, Voxilaprevir
This page covers Alpha-alanine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sofosbuvir, Velpatasvir, Voxilaprevir page lists 173 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 130 moderate · 40 minor.
From our pharmacist’s overview on the Sofosbuvir, Velpatasvir, Voxilaprevir page
“Vosevi (sofosbuvir, velpatasvir, and voxilaprevir) cures hepatitis C over a single short course, and that is exactly why I would be genuinely careful with supplements while taking it. Anything that drags its blood levels down can cost you the cure itself.”
Reviewed by 2 · Jul 18, 2026
Open the Sofosbuvir, Velpatasvir, Voxilaprevir interaction page
Where Alpha-alanine and Sofosbuvir, Velpatasvir, Voxilaprevir Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,062 of 1,452 supplements looked up here in the last 7 days
#200 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Alpha-alanine is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Alpha-alanine reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Alpha-alanine and Sofosbuvir, Velpatasvir, Voxilaprevir records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Alpha-alanine
What is Alpha-alanine?
- Sports and exercise support
- Blood sugar balance
- General amino acid supplementation
- Energy and metabolism support
Alpha-alanine (usually called alanine) is a non-essential amino acid your body can make on its own and that you also get from protein foods. Most people do not need a supplement, and strong human evidence for any specific health benefit is limited. If you are considering it, talk with your pharmacist or doctor first.
Amino acid (made by the body and found in protein-rich foods) · Capsules, tablets, powders, and as part of amino acid blends and protein supplements
An interaction check asks whether these two react with each other — it does not ask whether Alpha-alanine is a good idea for someone in your situation. Here is what our Alpha-alanine record says about it on its own.
Alpha-alanine: dosing
There is no well-established standard supplement dose of alanine for any specific health goal. The amount people get from a normal diet varies and is usually enough.If you choose to use an alanine supplement, follow the directions on the product label and do not exceed the recommended amount.
From our Alpha-alanine monograph — the full record covers uses, side effects and every documented interaction.
About Sofosbuvir, Velpatasvir, and Voxilaprevir
What Is Sofosbuvir, Velpatasvir, and Voxilaprevir Used For?
Brand name: Vosevi
Vosevi is used to treat chronic hepatitis C virus (HCV) infection in adults who do not have cirrhosis or who have compensated cirrhosis (mild liver scarring that is still functioning). It is specifically for people who have already been treated with an HCV regimen before and need a different option.
Vosevi is approved for adults with HCV genotype 1, 2, 3, 4, 5, or 6 who previously took a medicine that included an NS5A inhibitor. It is also approved for adults with genotype 1a or 3 who previously took sofosbuvir without an NS5A inhibitor.
Other Drugs & Alpha-alanine
Browse every other medication we’ve checked against Alpha-alanine — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Alpha-alanine against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Acetaminophen ›
- Abemaciclib ›
- Rivaroxaban ›
- Rosuvastatin ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Hydroxyurea ›
- Methamphetamine ›
- Valacyclovir ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Amitriptyline ›
- Methotrexate ›
- Bupropion ›
- Isotretinoin ›
- Bendamustine ›
- Amlodipine Besylate ›
- Amphetamine ›
- Fluoxetine ›
- Doxycycline ›
- Acyclovir ›
- Azithromycin ›
- Pregabalin ›
- Lamotrigine ›
- Gabapentin ›
- Dextroamphetamine ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Naproxen ›
- Letrozole ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Alpha-alanine list.
Alpha-alanine References
The 2 sources that drive our Alpha-alanine monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Alpha-alanine is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Amino acids — MedlinePlus (NIH) Source
- Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Alpha-alanine and Sofosbuvir, Velpatasvir, Voxilaprevir Together: Common Questions
Is it safe to take Alpha-alanine with Sofosbuvir, Velpatasvir, Voxilaprevir?
Should I take Alpha-alanine and Sofosbuvir, Velpatasvir, Voxilaprevir at the same time of day?
Does Sofosbuvir, Velpatasvir, Voxilaprevir interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.