Drug & supplement interaction

Alpha-lipoic Acid + Terlipressin

Terlipressin brand name: Terlivaz.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Alpha-lipoic Acid and Terlipressin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Alpha-lipoic Acid and Terlipressin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Terlipressin and Alpha-lipoic Acid in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Alpha-lipoic Acid safety at a glance

Alpha-lipoic Acid overall Use caution Generally well tolerated in most adults, but it can lower blood sugar and is best used under medical guidance.
Pregnancy Avoid There is not enough reliable safety information, so it is best to avoid during pregnancy.
Breastfeeding Avoid There is not enough reliable safety information, so it is best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Terlipressin and Alpha-lipoic Acid? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Alpha-lipoic Acid Does Interact With Other Medications

Alpha-lipoic Acid has 177 moderate, 86 minor known drug interactions in our database — Terlipressin isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against Alpha-lipoic Acid

Covers the 2,830 medications we’ve checked against Alpha-lipoic Acid. Pick one to open its full report.

What to actually watch for

What Alpha-lipoic Acid Itself Has Been Linked To

This is not an interaction — nothing below involves Terlipressin. It is the side-effect record for Alpha-lipoic Acid on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Alpha-lipoic Acid, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Confusion Worth acting on Additional detail

    “Orally, at least 50 published cases of insulin autoimmune syndrome (IAS) thought to be associated with use of alpha-lipoic acid have been reported. Most reported cases have been associated with alpha-lipoic acid supplements or enriched foods; IAS has not been reported with intake of alpha-lipoic acid in food.”

    Alpha-lipoic Acid · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    6 sources cited
    1. 16392. Furukawa N, Miyamura N, Nishida K, et al. Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. Diabetes Res Clin Pract 2007;75:366-7. PubMed
    2. 104656. Gullo D, Evans JL, Sortino G, Goldfine ID, Vigneri R. Insulin autoimmune syndrome (Hirata Disease) in European Caucasians taking a-lipoic acid. Clin Endocrinol (Oxf). 2014;81(2):204-9.
    3. 104657. Yukina M, Nuralieva N, Solovyev M, Troshina E, Vasilyev E. Insulin autoimmune syndrome. Endocrinol Diabetes Metab Case Rep. 2020;2020:19-0159. PubMed
    4. 104658. Moffa S, Improta I, Rocchetti S, Mezza T, Giaccari A. Potential cause-effect relationship between insulin autoimmune syndrome and alpha lipoic acid: Two case reports. Nutrition. 2019;57:1-4. PubMed
    5. 104659. Izzo V, Greco C, Corradini D, et al. Insulin autoimmune syndrome in an Argentine woman taking a-lipoic acid: A case report and review of the literature. SAGE Open Med Case Rep. 2018;6:2050313X18819601.
    6. 107893. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Scientific opinion on the relationship between intake of alpha-lipoic acid (thioctic acid) and the risk of insulin autoimmune syndrome. EFSA J 2021;19(6):e06577. PubMed
  • An allergic reaction Worth acting on Additional detail

    “Orally, skin rash and itching have been reported after use of alpha-lipoic acid. Topically, alpha-lipoic acid can cause local irritation, including burning, stinging, mild rash, or contact dermatitis. In one case, an 86-year-old female developed allergic contact dermatitis with severe itching and oozing after applying alpha-lipoic acid 5% cream to her lower extremities.”

    Alpha-lipoic Acid · Natural Medicines adverse-effect record, reported in dermatitis.

    6 sources cited
    1. 16391. Vincent HK, Bourguignon CM, Vincent KR, Taylor AG. Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study. J Alt Complement Med 2007;13:577-84. PubMed
    2. 20490. Porasuphatana S., Suddee S., Nartnampong A., Konsil J., Harnwong B., Santaweesuk A. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled
    3. 21674. Koh E. H., Lee W. J., Lee S. A., Kim E. H., Cho E. H., Jeong E., Kim D. W., Kim M. S., Park J. Y., Park K. G., Lee H. J., Lee I. K., Lim S., Jang H. C., Lee K. H., Lee K. U. Effects of alpha-lipoic Acid on body weight in obese subjects. Am J Med 2011;124( PubMed
    4. 96233. Boriani F, Granchi D, Roatti G, Merlini L, Sabattini T, Baldini N. Alpha-lipoic acid after median nerve decompression at the carpal tunnel: a randomized controlled trial. J Hand Surg Am. 2017 Apr;42(4):236-42. PubMed
    5. 104650. Derosa G, D'Angelo A, Preti P, Maffioli P. Safety and efficacy of alpha lipoic acid during 4 years of observation: A retrospective, clinical trial in healthy subjects in primary prevention. Drug Des Devel Ther. 2020;14:5367-5374.
    6. 12021. Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol 2003;149:841-9.
  • Heartburn Additional detail

    “Orally, heartburn, nausea, and vomiting have been reported after use of alpha-lipoic acid. Higher doses (1200-1800 mg daily) seem to cause more severe effects than lower doses (600 mg daily). Alpha-lipoic acid may also cause a burning sensation from the throat to the stomach, abdominal discomfort, or bitter taste when used orally.”

    Alpha-lipoic Acid · Natural Medicines adverse-effect record, reported in dyspepsia.

    6 sources cited
    1. 3557. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33.
    2. 12106. Ziegler D, Nowak H, Kempler P, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. Diabet Med 2004;21:114-21.
    3. 16391. Vincent HK, Bourguignon CM, Vincent KR, Taylor AG. Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study. J Alt Complement Med 2007;13:577-84. PubMed
    4. 20475. Ziegler D., Ametov A., Barinov A., Dyck P. J., Gurieva I., Low P. A., Munzel U., Yakhno N., Raz I., Novosadova M., Maus J., Samigullin, R. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Car
    5. 30844. Tang, J., Wingerchuk, D. M., Crum, B. A., Rubin, D. I., and Demaerschalk, B. M. Alpha-lipoic acid may improve symptomatic diabetic polyneuropathy. Neurologist. 2007;13(3):164-167. PubMed
    6. 96225. Sarezky D, Raquib AR, Dunaief JL, Kim BJ. Tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye. Clin Ophthalmol. 2016 Sep 29;10:1899-1903. PubMed
  • A change in taste / Stomach upset Additional detail

    Recorded for Alpha-lipoic Acid in the same Natural Medicines adverse-effect record shown under Heartburn above.

  • Blurred vision / Sweating / A fast or pounding heartbeat Additional detail

    Recorded for Alpha-lipoic Acid in the same Natural Medicines adverse-effect record shown under Confusion above.

  • Low blood pressure Additional detail

    “Orally, hypotension has been reported rarely in a clinical trial.”

    Alpha-lipoic Acid · Natural Medicines adverse-effect record, reported in hypotension.

    1 source cited
    1. 104650. Derosa G, D'Angelo A, Preti P, Maffioli P. Safety and efficacy of alpha lipoic acid during 4 years of observation: A retrospective, clinical trial in healthy subjects in primary prevention. Drug Des Devel Ther. 2020;14:5367-5374.
  • Itching Additional detail

    Recorded for Alpha-lipoic Acid in the same Natural Medicines adverse-effect record shown under An allergic reaction above.

Showing the 10 most notable of 15 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Alpha-lipoic Acid — expand a row for the licensed statement it rests on. We haven’t matched Terlipressin to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Terlipressin.

One more smart check

Taking Alpha-lipoic Acid as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4,223 real supplement products containing Alpha-lipoic Acid, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Alpha-lipoic Acid. Even though Alpha-lipoic Acid itself has no known interaction with Terlipressin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Alpha-lipoic Acid and Terlipressin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Alpha-lipoic Acid
Top 5%

#34 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Terlipressin
Steady interest

#2,645 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Alpha-lipoic Acid reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Alpha-lipoic Acid and Terlipressin records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Alpha-lipoic Acid

What is Alpha-lipoic Acid?

Alpha-lipoic Acid
  • Diabetic nerve pain (neuropathy)
  • Blood sugar support in diabetes
  • Antioxidant support
  • Liver health
  • Skin aging (topical and oral)

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help, but evidence for most other uses is limited. It is generally well tolerated, but talk to your pharmacist or doctor before using it, especially if you have diabetes or thyroid problems.

Not applicable (a naturally occurring compound, not a plant part) · Capsules, tablets, softgels, and injectable forms (used in some countries)

An interaction check asks whether these two react with each other — it does not ask whether Alpha-lipoic Acid is a good idea for someone in your situation. Here is what our Alpha-lipoic Acid record says about it on its own.

Alpha-lipoic Acid: dosing

There is no single official or standardized dose of alpha-lipoic acid. Doses used in studies have varied widely depending on the condition and whether the oral or injectable form was used.The best approach is to follow the directions on the product label and choose a product from a reputable brand.

From our Alpha-lipoic Acid monograph — the full record covers uses, side effects and every documented interaction.

Read the full Alpha-lipoic Acid monograph & all interactions
Keep checking

Other Drugs & Alpha-lipoic Acid

Browse every other medication we’ve checked against Alpha-lipoic Acid — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
177Moderate
86Minor
2,566No known interaction
Moderate

177 interactions

Showing 60 of 177 moderate interactions — see all 177 on the Alpha-lipoic Acid page.

Minor

86 interactions

Showing 60 of 86 minor interactions — see all 86 on the Alpha-lipoic Acid page.

No interaction 2,566 drugs checked — show the list
Evidence & sources

Alpha-lipoic Acid References

The 48 references that drive our Alpha-lipoic Acid monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  2. Anon. Alpha-lipoic acid. Altern Med Rev 1998;3:308-10.
  3. Konrad T, Vicini P, Kusterer K, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with Type 2 diabetes. Diabetes Care 1999;22:280-7. PubMed
  4. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33.
  5. Gleiter CH, Schreeb KH, Freudenthaler S, et al. Lack of interaction between thioctic acid, glibenclamide and acarbose. Br J Clin Pharmacol 1999;48:819-25. PubMed
  6. Jacob S, Henriksen EJ, Tritschler HJ, et al. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabet 1996;104:284-8. PubMed
  7. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45:872-4.
  8. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled, pilot trial. Free Rad Biol Med 1999;27:309-14.
  9. Segermann J, Hotze A, Ulrich H, Rao GS. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung 1991;41:1294-8.
  10. Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol 2003;149:841-9.
  11. Ziegler D, Nowak H, Kempler P, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. Diabet Med 2004;21:114-21.
  12. Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
  13. Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
  14. Vincent HK, Bourguignon CM, Vincent KR, Taylor AG. Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study. J Alt Complement Med 2007;13:577-84. PubMed
  15. Furukawa N, Miyamura N, Nishida K, et al. Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. Diabetes Res Clin Pract 2007;75:366-7. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Alpha-lipoic Acid and Terlipressin Together: Common Questions

Is it safe to take Alpha-lipoic Acid with Terlipressin?
We do not list a known interaction between Alpha-lipoic Acid and Terlipressin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Alpha-lipoic Acid interact with any other medications?
Yes. Alpha-lipoic Acid has 263 documented drug interactions in our database — Terlipressin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Terlipressin and Alpha-lipoic Acid?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.