Drug & supplement interaction

Alpine Ragwort + Sirolimus (albumin bound)

Sirolimus (albumin bound) brand name: Fyarro.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Alpine Ragwort and Sirolimus (albumin bound) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Alpine Ragwort and Sirolimus (albumin bound)

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sirolimus (albumin bound) and Alpine Ragwort in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Alpine Ragwort safety at a glance

Alpine Ragwort overall Avoid It contains liver-toxic pyrrolizidine alkaloids and should generally not be taken internally.
Pregnancy Likely Unsafe When used orally. Alpine ragwort preparations containing hepatotoxic pyrrolizidine alkaloid (PA) constituents might be teratogenic and hepatotoxic. There is ins... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in alpine ragwort are excreted in milk. There is insufficient reliable information availa... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sirolimus (albumin bound) and Alpine Ragwort? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sirolimus (albumin bound)

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sirolimus (albumin bound) is filed under 4 classifications — including immunosuppressants, p-glycoprotein substrates, cytochrome p450 3a4 (cyp3a4) substrates. Alpine Ragwort has documented interactions with 1 drug class — the most serious being cytochrome p450 3a4 (cyp3a4) inducers (moderate) — and none of Sirolimus (albumin bound)’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Alpine Ragwort Does Interact With Other Medications

Alpine Ragwort has 87 moderate known drug interactions in our database — Sirolimus (albumin bound) isn’t one of them. If you take anything else, check it against the full list below.

Moderate 87 No known interaction 2,743 (incl. Sirolimus (albumin bound))
Taking anything else?

Check Another of Your Medications Against Alpine Ragwort

Covers the 2,830 medications we’ve checked against Alpine Ragwort. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Alpine Ragwort and Sirolimus (albumin bound) May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Raised blood pressure Worth acting on Additional detail

    Alpine Ragwort

    “Orally, the major concern with alpine ragwort use is its pyrrolizidine alkaloid (PA) content. These constituents can cause lung damage with pulmonary-arterial hypertension.”

    Alpine Ragwort · Natural Medicines adverse-effect record, reported in hypertension.

    2 sources cited
    1. 12841. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
    2. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.

    Sirolimus (albumin bound)

    Listed in the ADVERSE REACTIONS section of the FDA label for Sirolimus (albumin bound). Read the label on DailyMed ›

  • Diarrhea / Vomiting Additional detail

    Alpine Ragwort

    “Orally, the major concern with alpine ragwort use is its pyrrolizidine alkaloid (PA) content. These constituents can cause liver injury. Chronic exposure to other plants containing hepatotoxic PA constituents is associated with veno-occlusive disease. Subacute veno-occlusive disease can cause vague symptoms, including colicky pains, vomiting, diarrhea, and ascites within several days;”

    Alpine Ragwort · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 12841. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
    2. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
    3. 4021. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.

    Sirolimus (albumin bound)

    Listed in the ADVERSE REACTIONS section of the FDA label for Sirolimus (albumin bound). Read the label on DailyMed ›

Reported for Alpine Ragwort but not commonly for Sirolimus (albumin bound): liver problems.

Effects for Sirolimus (albumin bound) come from the ADVERSE REACTIONS section of its FDA label; effects for Alpine Ragwort come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Alpine Ragwort in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Alpine ragwort preparations containing hepatotoxic pyrrolizidine alkaloid (PA) constituents might be teratogenic and hepatotoxic. There is insufficient reliable information available about the safety of alpine ragwort products that do not contain hepatotoxic PAs when used during pregnancy.

Lactation Likely Unsafe

When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in alpine ragwort are excreted in milk. There is insufficient reliable information available about the safety of alpine ragwort products that do not contain hepatotoxic PAs when used during lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Sirolimus (albumin bound)

This page covers Alpine Ragwort only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sirolimus (albumin bound) page lists 171 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate), Active Hexose Correlated Compound (ahcc) (moderate) and Adrafinil (moderate).

By severity: 2 major · 142 moderate · 27 minor.

From our pharmacist’s overview on the Sirolimus (albumin bound) page

“Fyarro, the albumin-bound form of sirolimus used to treat advanced malignant PEComa, a rare cancer, is a medication I would guard carefully from supplement interference, and the 171 ingredients on this page show why. Most of them (121 through the CYP3A4 enzyme, 37 through the P-glycoprotein transporter) can shift how much sirolimus act…”

Reviewed by 2 · Jul 18, 2026

Open the Sirolimus (albumin bound) interaction page

How much people look this up

Where Alpine Ragwort and Sirolimus (albumin bound) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Alpine Ragwort
Steady interest

#799 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sirolimus (albumin bound)
Top 10%

#259 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Alpine Ragwort reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Alpine Ragwort and Sirolimus (albumin bound) records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Alpine Ragwort

What is Alpine Ragwort?

Alpine Ragwort
  • Traditional wound care
  • Minor bleeding or bruises
  • Digestive complaints
  • Menstrual discomfort
  • Folk remedy for inflammation

Alpine Ragwort is a wild plant in the daisy family that contains pyrrolizidine alkaloids (PAs), which can severely damage the liver. There is no good scientific evidence that it works for any health condition, and the safety risks are serious. We do not recommend using it.

Senecio nemorensis · Asteraceae · Aerial parts (leaves, stems, and flowers) · Dried herb, tea, tincture, and traditional topical preparations

An interaction check asks whether these two react with each other — it does not ask whether Alpine Ragwort is a good idea for someone in your situation. Here is what our Alpine Ragwort record says about it on its own.

Alpine Ragwort: dosing

There is no established safe dose for Alpine Ragwort. Because of its toxic pyrrolizidine alkaloids, health authorities generally advise against taking it internally at all.We do not provide a recommended amount for this plant.

From our Alpine Ragwort monograph — the full record covers uses, side effects and every documented interaction.

Read the full Alpine Ragwort monograph & all interactions
Medication

About Sirolimus (with albumin) Injection

What Is Sirolimus (with albumin) Injection Used For?

Brand name: Fyarro

Fyarro (sirolimus protein-bound particles for injectable suspension) is approved to treat adults with locally advanced unresectable (cannot be surgically removed) or metastatic (spread to other parts of the body) malignant perivascular epithelioid cell tumor, known as PEComa. This is a rare type of soft-tissue tumor.

See full Sirolimus (with albumin) Injection drug information
Keep checking

Other Drugs & Alpine Ragwort

Browse every other medication we’ve checked against Alpine Ragwort — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
87Moderate
0Minor
2,742No known interaction
87 Moderate 2,742 No interaction
Moderate

87 interactions

Showing 60 of 87 moderate interactions — see all 87 on the Alpine Ragwort page.

No interaction 2,742 drugs checked — show the list

We also checked Alpine Ragwort against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,742 medications checked with no known interaction — see the full Alpine Ragwort list.

See the full Alpine Ragwort interactions page
See every supplement checked against Sirolimus (albumin bound), ranked by severity
Evidence & sources

Alpine Ragwort References

The 4 references that drive our Alpine Ragwort monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  2. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  3. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  4. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Alpine Ragwort and Sirolimus (albumin bound) Together: Common Questions

Is it safe to take Alpine Ragwort with Sirolimus (albumin bound)?
We do not list a known interaction between Alpine Ragwort and Sirolimus (albumin bound). That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Alpine Ragwort and Sirolimus (albumin bound) have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Alpine Ragwort and Sirolimus (albumin bound) combination checked?
Interactions in our licensed database are recorded against drug classes. Sirolimus (albumin bound) is filed under 4 classifications, and Alpine Ragwort has documented interactions with 1 drug class — none of Sirolimus (albumin bound)'s classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Alpine Ragwort interact with any other medications?
Yes. Alpine Ragwort has 87 documented drug interactions in our database — Sirolimus (albumin bound) is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sirolimus (albumin bound) interact with any supplements?
Yes. Sirolimus (albumin bound) has documented interactions with 171 supplements in our database — Alpine Ragwort is not one of them. The Sirolimus (albumin bound) interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Alpine Ragwort monograph Uses, safety profile, and every drug interaction in one place Sirolimus (with albumin) Injection drug information The full plain-English guide to this medication Sirolimus (albumin bound) supplement interactions Every supplement checked against Sirolimus (albumin bound), ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.