Medication interaction hub

What Supplements Interact with Sirolimus (albumin bound)?

Sirolimus (albumin bound) brand name: Fyarro. Every interaction below applies to the brands too.

171 Interactions 2 Major 142 Moderate 27 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Sirolimus (albumin bound)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Sirolimus (albumin bound) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Fyarro, the albumin-bound form of sirolimus used to treat advanced malignant PEComa, a rare cancer, is a medication I would guard carefully from supplement interference, and the 171 ingredients on this page show why. Most of them (121 through the CYP3A4 enzyme, 37 through the P-glycoprotein transporter) can shift how much sirolimus actually reaches the blood, and with this drug, small changes in blood level matter. The two major-rated entries are grapefruit, which can push levels up, and St. John's wort, which can pull them down enough to blunt treatment.

A second cluster of 53 ingredients, including astragalus and American ginseng, works differently, stimulating the immune activity sirolimus is meant to suppress. Even fish oil raised sirolimus exposure enough in transplant research that doses were cut by 25 percent. Beyond the two majors, 142 entries are moderate and 27 minor, so check each product against the full list rather than assume it is harmless.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 142 Minor 27 No known interaction 1,281

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Sirolimus (albumin bound): Top Interactions at a Glance

The most significant Sirolimus (albumin bound) supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 171 interacting ingredients — plus 1,281 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Sirolimus (albumin bound) + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Sirolimus (albumin bound)i

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Probable St. John's Wort + Sirolimus (albumin bound)i

St.

Read the full interaction
The complete list

Every Supplement Checked Against Sirolimus (albumin bound)

All 1,452 ingredients in our database, ranked by severity — 171 with a Sirolimus (albumin bound) interaction on file and 1,281 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Sirolimus (albumin bound)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bupleurum with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bupleurum might decrease the effects of immunosuppressants.

Full Bupleurum + Sirolimus (albumin bound) answer

Can you take Ipriflavone with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concurrent use of ipriflavone and immunosuppressant drugs might have additive effects on inhibiting immune function.

Full Ipriflavone + Sirolimus (albumin bound) answer

Can you take Jiaogulan with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jiaogulan might decrease the effectiveness of immunosuppressive therapy.

Full Jiaogulan + Sirolimus (albumin bound) answer

Can you take Kava with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. It is unclear if kava inhibits P-glycoprotein (P-gp); research is conflicting.

Full Kava + Sirolimus (albumin bound) answer

Can you take Kefir with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kefir might increase the risk of bacterial and yeast infections in patients taking immunosuppressants.

Full Kefir + Sirolimus (albumin bound) answer

Can you take Kratom with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Kratom might increase the levels and clinical effects of drugs metabolized by CYP3A4.

Full Kratom + Sirolimus (albumin bound) answer

Can you take Larch Arabinogalactan with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.

Full Larch Arabinogalactan + Sirolimus (albumin bound) answer

Can you take Lemongrass with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.

Full Lemongrass + Sirolimus (albumin bound) answer

Can you take Lentinan with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Laboratory research suggests that lentinan might increase the activity of cytochrome P450 3A4 (CYP3A4).

Full Lentinan + Sirolimus (albumin bound) answer

Can you take Licorice with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase or decrease levels of drugs metabolized by CYP3A4.

Full Licorice + Sirolimus (albumin bound) answer

Can you take Lime with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that phenolics in lime juice inhibit cytochrome P450 3A4.

Full Lime + Sirolimus (albumin bound) answer

Can you take Lion's Mane Mushroom with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.

Full Lion's Mane Mushroom + Sirolimus (albumin bound) answer

Can you take Mace with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that mace lignans can suppress immune function.

Full Mace + Sirolimus (albumin bound) answer

Can you take Maritime Pine with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.

Full Maritime Pine + Sirolimus (albumin bound) answer

Can you take Melatonin with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, melatonin might interfere with immunosuppressive therapy.

Full Melatonin + Sirolimus (albumin bound) answer

Can you take Methoxylated Flavones with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that methoxylated flavones might inhibit cytochrome P450 3A4 (CYP3A4).

Full Methoxylated Flavones + Sirolimus (albumin bound) answer

Can you take Milk Thistle with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Milk thistle might decrease the clearance of sirolimus.

Full Milk Thistle + Sirolimus (albumin bound) answer

Can you take Moringa with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.

Full Moringa + Sirolimus (albumin bound) answer

Can you take Neem with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP3A4 substrates.

Full Neem + Sirolimus (albumin bound) answer

Can you take Oregon Grape with Sirolimus (albumin bound)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.

Full Oregon Grape + Sirolimus (albumin bound) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Sirolimus (albumin bound) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Sirolimus (albumin bound), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Sirolimus (albumin bound) sits in 4 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Sirolimus (albumin bound) through this category.

Immunosuppressants 53 ingredients

Medications that damp down the immune system. Supplements that stimulate immunity can work against them.

53 of the supplement ingredients on this page reach Sirolimus (albumin bound) through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Sirolimus (albumin bound) through this category.

Sirolimus (Rapamune) 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Sirolimus (albumin bound) through this category.

About Sirolimus (albumin bound)

Sirolimus (with albumin) is an mTOR inhibitor used as Fyarro injection to treat malignant perivascular epithelioid cell tumor (PEComa) in adults.

Generic name: Sirolimus (albumin bound)  ·  Brand name: Fyarro.

See the full Sirolimus (with albumin) Injection drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Sirolimus (albumin bound)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Sirolimus (albumin bound).

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Sirolimus (albumin bound) & Supplements: Common Questions

What supplements interact with Sirolimus (albumin bound)?
Our database currently documents 171 ingredients with a known Sirolimus (albumin bound) interaction (2 major, 142 moderate, 27 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 171. The highest-ranked right now: Grapefruit, St. John's Wort, Cannabidiol (cbd).
Which Sirolimus (albumin bound) supplement interactions are the most serious?
The 2 major-rated combinations — led by Grapefruit and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Sirolimus (albumin bound)?
Plenty of supplements coexist fine with Sirolimus (albumin bound); a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Fyarro have the same supplement interactions as Sirolimus (albumin bound)?
Yes — Fyarro all contain Sirolimus (albumin bound), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Sirolimus (albumin bound) and my other medications?
This page covers Sirolimus (albumin bound) against supplements and herbal ingredients. Checking Sirolimus (albumin bound) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Sirolimus (with albumin) Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.