Panax Ginseng + Sirolimus (albumin bound)
Sirolimus (albumin bound) brand name: Fyarro.
Sirolimus (albumin bound) falls into 2 drug categories that Panax Ginseng can interact with; the most serious is rated moderate. Theoretically, Panax ginseng might increase or decrease levels of drugs metabolized by CYP3A4.
Read the full interaction reportPanax Ginseng and Sirolimus (albumin bound)
These two interact in 2 distinct ways. Each one is explained separately below.
Why Are There 2 Interactions?
Panax Ginseng interacts with whole categories of medication. Sirolimus (albumin bound) falls into 2 of those categories, so it can interact with Panax Ginseng in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES
1 of 2Why this applies to Sirolimus (albumin bound)
Sirolimus (albumin bound) falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES — the group Panax Ginseng interacts with.
Panax ginseng may affect the clearance of drugs metabolized by CYP3A4. One such drug is imatinib. Inhibition of CYP3A4 was believed to be responsible for a case of imatinib-induced hepatotoxicity. In contrast, Panax ginseng has been shown to increase the clearance of midazolam, another drug metabolized by CYP3A4. Clinical research shows that Panax ginseng can reduce midazolam area under the curve by 44%, maximum plasma concentration by 26%, and time to reach maximum plasma concentration by 29%. Midazolam metabolism was also increased in animals given Panax ginseng. Until more is known, use Panax ginseng cautiously in combination with CYP3A4 substrates.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Your sirolimus (Fyarro) is cleared from the body by a liver enzyme called CYP3A4, and Panax ginseng can tug on that enzyme in either direction. The tricky part is that we can't reliably predict which way it'll go. If ginseng slows the enzyme, sirolimus could build up and raise your risk of side effects like mouth sores, low blood counts, infections, high cholesterol, and trouble healing. If it speeds the enzyme up, your sirolimus level could drop and the medicine may not control your tumor as well.
Sirolimus is a narrow-margin cancer drug where even small swings matter, so I'd treat this cautiously. This is mostly theoretical, but please don't start ginseng without first checking with your oncology team or pharmacist.
- Malati CY, Robertson SM, Hunt JD, Chairez C, Alfaro RM, Kovacs JA, Penzak SR. Influence of Panax ginseng on cytochrome P450 (CYP)3A and P-glycoprotein (P-gp) activity in healthy participants. J Clin Pharmacol 2012;52(6):932-9.
- Bilgi N, Bell K, Ananthakrishnan AN, Atallah E. Imatinib and Panax ginseng: a potential interaction resulting in liver toxicity. Ann Pharmacother 2010;44(5):926-8.
- Kim Y, Jo JJ, Cho P, et al. Characterization of red ginseng-drug interaction by CYP3A activity increased in high dose administration in mice. Biopharm Drug Dispos. 2020;41(7):295-306. PubMed
IMMUNOSUPPRESSANTS
2 of 2Sirolimus (albumin bound) also falls under IMMUNOSUPPRESSANTS.
Panax ginseng might have immune system stimulating properties.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the concern with pairing Panax ginseng and Fyarro (albumin-bound sirolimus). Sirolimus works partly by quieting down your immune system, and that calming effect is part of how it's used in your treatment. Ginseng, on the other hand, may gently rev the immune system up. In theory, those two pull in opposite directions, so the worry is that ginseng could blunt some of what sirolimus is doing.
I want to be honest that this is a theoretical concern based on weaker evidence, not something proven in people taking this exact drug. Still, since sirolimus is serious therapy for a serious condition, I wouldn't want anything working against it. Please talk with your oncology team or pharmacist before adding ginseng so they can weigh in.
- Shin HR, Kim JY, Yun TK, et al. The cancer-preventive potential of Panax ginseng: a review of human and experimental evidence. Cancer Causes Control 2000;11:565-76. PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Panax Ginseng Also Interacts With Other Medications
Panax Ginseng has 1,129 moderate known drug interactions in our database — the Sirolimus (albumin bound) one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Panax Ginseng
We haven’t checked that one against Panax Ginseng yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Panax Ginseng. Pick one to open its full report.
See Every Supplement That Interacts With Sirolimus (albumin bound)
This page covers Panax Ginseng only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sirolimus (albumin bound) page lists 171 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate), Active Hexose Correlated Compound (ahcc) (moderate) and Adrafinil (moderate).
By severity: 2 major · 142 moderate · 27 minor.
From our pharmacist’s overview on the Sirolimus (albumin bound) page
“Fyarro, the albumin-bound form of sirolimus used to treat advanced malignant PEComa, a rare cancer, is a medication I would guard carefully from supplement interference, and the 171 ingredients on this page show why. Most of them (121 through the CYP3A4 enzyme, 37 through the P-glycoprotein transporter) can shift how much sirolimus act…”
Reviewed by 2 · Jul 18, 2026
Taking Panax Ginseng as Part of a Dietary Supplement Product? Check It for Interactions
We hold 517 real supplement products containing Panax Ginseng, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Panax Ginseng. Your product may carry other ingredients that interact with Sirolimus (albumin bound) too, on top of Panax Ginseng — and those would not show on this page. Find your product and we’ll check every ingredient on its label:
Where Panax Ginseng and Sirolimus (albumin bound) Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#236 of 1,452 supplements looked up here in the last 7 days
#277 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Panax Ginseng
What is Panax Ginseng?
- Boosting energy and fighting fatigue
- Improving mental focus and memory
- Coping with stress (adaptogen)
- Erectile dysfunction
- Supporting immune health
- Blood sugar support
Panax ginseng is a popular traditional herb used to boost energy, ease stress, and support overall wellness, though scientific evidence is mixed and mostly preliminary. It is generally well tolerated for short-term use in healthy adults, but it can cause side effects like trouble sleeping and may not be safe during pregnancy or breastfeeding. Always check with your pharmacist or doctor before starting it, especially if you have a medical condition or take other medicines.
About Sirolimus (with albumin) Injection
What Is Sirolimus (with albumin) Injection Used For?
Brand name: Fyarro
Fyarro (sirolimus protein-bound particles for injection) is used to treat adults with locally advanced unresectable or metastatic malignant perivascular epithelioid cell tumor (PEComa).
Unresectable means the tumor can't be removed with surgery. Metastatic means it has spread to other parts of the body.
Other Drugs & Panax Ginseng
Browse every other medication we’ve checked against Panax Ginseng — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1,129 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Metronidazole ›
- Phentermine ›
- Aspirin ›
- Hydrocortisone ›
- Insulin (rdna) ›
- Methylphenidate ›
- Naproxen ›
- Erythromycin ›
- Estradiol ›
- Minocycline ›
- Propranolol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Phenylpropanolamine ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Glyburide ›
- Insulin (pork) ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Nicotine ›
- Oxybutynin ›
- Oxycodone ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Triamcinolone ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Doxorubicin ›
- Fluticasone ›
- Formoterol ›
- Insulin (human) ›
- Miconazole ›
- Morphine Sulfate ›
- Phenylephrine ›
- Procainamide ›
- Pseudoephedrine ›
- Trimipramine ›
- Amphetamine ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Diethylpropion ›
- Everolimus ›
Showing 60 of 1,129 moderate interactions — see all 1,129 on the Panax Ginseng page.
No interaction 1,700 drugs checked — show the list
We also checked Panax Ginseng against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Ivermectin ›
- Acetaminophen ›
- Rosuvastatin ›
- Escitalopram ›
- Isotretinoin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Levothyroxine, Liothyronine ›
- Methotrexate ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Doxycycline ›
- Pregabalin ›
- Bendamustine ›
- Gabapentin ›
- Lamotrigine ›
- Acyclovir ›
- Methylene Blue ›
- Ciprofloxacin ›
- Candesartan Cilexetil ›
- Amoxicillin, Clavulanate Potassium ›
- Calcium Oxybate, Magnesium Oxybate, Potassium Oxybate, Sodium Oxybate ›
- Ezetimibe ›
- Cephalexin ›
- Atenolol, Chlorthalidone ›
- Cyclopentolate ›
- Avatrombopag Maleate ›
- Levetiracetam ›
- Levodopa ›
- Bendroflumethiazide, Rauwolfia Serpentina ›
- Sacubitril, Valsartan ›
- Enalapril Maleate ›
- Thyroid Hormone ›
- Isoniazid, Pyrazinamide, Rifampin ›
- Carbidopa, Levodopa ›
- Mannitol ›
- Daunorubicin, Cytarabine ›
- Valsartan ›
- Bupivacaine, Meloxicam ›
- Alginic Acid, Aluminum Hydroxide ›
- Spironolactone ›
- Ceftolozane Sulfate, Tazobactam Sodium ›
- Hydrocortisone, Clioquinol, Pramoxine ›
- Bismuth Subcarbonate, Calcium Carbonate, Opium ›
- Roxithromycin ›
- Charcoal (otc Drug) ›
- Atenolol ›
- Peginterferon Alfa-2a, Ribavirin ›
- Aminolevulinic Acid Hydrochloride ›
- Magnesium Hydroxide (otc Drug) ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Atropine Methyl Nitrate, Digestive Enzymes ›
- Levothyroxine Sodium ›
- Sodium Bicarbonate (otc Drug) ›
- Cytomegalovirus Immune Globulin ›
- Alpha-1 Proteinase Inhibitor ›
- Articaine, Epinephrine ›
Showing the 60 most looked-up of 1,700 medications checked with no known interaction — see the full Panax Ginseng list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Taking Panax Ginseng and Sirolimus (albumin bound) Together: Common Questions
Can you take Panax Ginseng with Sirolimus (albumin bound)?
Why are there 2 interactions listed for Panax Ginseng and Sirolimus (albumin bound)?
How serious is the Panax Ginseng and Sirolimus (albumin bound) interaction?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.