Drug & supplement interaction

Bergamot + Sirolimus (albumin bound)

Sirolimus (albumin bound) brand name: Fyarro.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Bergamot and Sirolimus (albumin bound) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Bergamot and Sirolimus (albumin bound)

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sirolimus (albumin bound) and Bergamot in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bergamot safety at a glance

Bergamot overall Use caution Oral extract appears generally well tolerated short-term, but the essential oil can be toxic if swallowed and can cause sun-related skin reactions.
Pregnancy Possibly Unsafe When the oil is used topically. There is insufficient reliable information available about the safety of bergamot when taken by mouth in medicinal amounts; avoi... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When the oil is used topically. There is insufficient reliable information available about the safety of bergamot when taken by mouth in medicinal amounts; avoi... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sirolimus (albumin bound) and Bergamot? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sirolimus (albumin bound)

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sirolimus (albumin bound) is filed under 4 classifications — including immunosuppressants, p-glycoprotein substrates, cytochrome p450 3a4 (cyp3a4) substrates. Bergamot has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and photosensitizing drugs (moderate) — and none of Sirolimus (albumin bound)’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bergamot Does Interact With Other Medications

Bergamot has 410 moderate known drug interactions in our database — Sirolimus (albumin bound) isn’t one of them. If you take anything else, check it against the full list below.

Moderate 410 No known interaction 2,420 (incl. Sirolimus (albumin bound))
Taking anything else?

Check Another of Your Medications Against Bergamot

Covers the 2,830 medications we’ve checked against Bergamot. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Bergamot and Sirolimus (albumin bound) May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Muscle pain Additional detail

    Bergamot

    “Orally, muscle cramps have been reported for a patient starting one week after switching from drinking 4 liters of black tea to drinking 4 liters of Earl Grey tea daily. The muscle cramps were attributed bergapten, a constituent of bergamot essential oil in Earl Grey tea.”

    Bergamot · Natural Medicines adverse-effect record, reported in muscle cramps.

    1 source cited
    1. 34344. Finsterer, J. Earl Grey tea intoxication. Lancet 4-27-2002;359(9316):1484. PubMed

    Sirolimus (albumin bound)

    Listed in the ADVERSE REACTIONS section of the FDA label for Sirolimus (albumin bound). Read the label on DailyMed ›

Reported for Bergamot but not commonly for Sirolimus (albumin bound): sun sensitivity and heartburn.

Effects for Sirolimus (albumin bound) come from the ADVERSE REACTIONS section of its FDA label; effects for Bergamot come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Bergamot in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When the oil is used topically. There is insufficient reliable information available about the safety of bergamot when taken by mouth in medicinal amounts; avoid use.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Bergamot or Sirolimus (albumin bound)

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Bergamot or Sirolimus (albumin bound), not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Sirolimus (albumin bound)

This page covers Bergamot only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sirolimus (albumin bound) page lists 171 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate), Active Hexose Correlated Compound (ahcc) (moderate) and Adrafinil (moderate).

By severity: 2 major · 142 moderate · 27 minor.

From our pharmacist’s overview on the Sirolimus (albumin bound) page

“Fyarro, the albumin-bound form of sirolimus used to treat advanced malignant PEComa, a rare cancer, is a medication I would guard carefully from supplement interference, and the 171 ingredients on this page show why. Most of them (121 through the CYP3A4 enzyme, 37 through the P-glycoprotein transporter) can shift how much sirolimus act…”

Reviewed by 2 · Jul 18, 2026

Open the Sirolimus (albumin bound) interaction page

One more smart check

Taking Bergamot as Part of a Dietary Supplement Product? Check It for Interactions

We hold 47 real supplement products containing Bergamot, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bergamot. Even though Bergamot itself has no known interaction with Sirolimus (albumin bound), another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bergamot and Sirolimus (albumin bound) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bergamot
Top half

#527 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sirolimus (albumin bound)
Top 25%

#305 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bergamot reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Bergamot and Sirolimus (albumin bound) records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bergamot

What is Bergamot?

Bergamot
  • High cholesterol
  • Heart and metabolic health
  • Anxiety and stress (aromatherapy)
  • Antimicrobial/antiseptic
  • Skin care and fragrance

Bergamot is a Mediterranean citrus fruit, and its standardized extract is most often used to support cholesterol and heart health, with some early but promising research. The essential oil is widely used for fragrance and aromatherapy but should not be taken by mouth, and it can make skin more sensitive to sunlight. Talk with your pharmacist or doctor before using bergamot supplements, especially if you take medicine for cholesterol or blood sugar.

Citrus bergamia · Rutaceae · Fruit (juice, peel, and essential oil) and standardized flavonoid extract · Capsules, tablets, essential oil, standardized extract, food and drink flavoring

An interaction check asks whether these two react with each other — it does not ask whether Bergamot is a good idea for someone in your situation. Here is what our Bergamot record says about it on its own.

Bergamot: dosing

There is no official, well-established standard dose for bergamot. Supplements are often standardized to a percentage of total flavonoids, and the amount per capsule varies a lot between products.The best approach is to follow the directions on the product label and not exceed the recommended amount. Because product strength and quality differ, choose brands that test for quality and clearly list the standardized flavonoid content.Bergamot essential oil should not be taken by mouth.

From our Bergamot monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bergamot monograph & all interactions
Medication

About Sirolimus (with albumin) Injection

What Is Sirolimus (with albumin) Injection Used For?

Brand name: Fyarro

Fyarro (sirolimus protein-bound particles for injectable suspension) is approved to treat adults with locally advanced unresectable (cannot be surgically removed) or metastatic (spread to other parts of the body) malignant perivascular epithelioid cell tumor, known as PEComa. This is a rare type of soft-tissue tumor.

See full Sirolimus (with albumin) Injection drug information
Keep checking

Other Drugs & Bergamot

Browse every other medication we’ve checked against Bergamot — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
410Moderate
0Minor
2,419No known interaction
410 Moderate 2,419 No interaction
Moderate

410 interactions

Showing 60 of 410 moderate interactions — see all 410 on the Bergamot page.

No interaction 2,419 drugs checked — show the list

We also checked Bergamot against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,419 medications checked with no known interaction — see the full Bergamot list.

See the full Bergamot interactions page
See every supplement checked against Sirolimus (albumin bound), ranked by severity
Evidence & sources

Bergamot References

The 17 references that drive our Bergamot monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Naganuma M, Hirose S, Nakayama Y, et al. A study of the phototoxicity of lemon oil. Arch Dermatol Res 1985;278:31-6. . PubMed
  4. Kaddu, S., Kerl, H., and Wolf, P. Accidental bullous phototoxic reactions to bergamot aromatherapy oil. J.Am.Acad.Dermatol. 2001;45(3):458-461. PubMed
  5. Finsterer, J. Earl Grey tea intoxication. Lancet 4-27-2002;359(9316):1484. PubMed
  6. Gruson, L. M. and Chang, M. W. Berloque dermatitis mimicking child abuse. Arch.Pediatr.Adolesc.Med. 2002;156(11):1091-1093. PubMed
  7. Weisenseel, P. and Woitalla, S. [Toxic mustard plaster dematitis and phototoxic dematitis after application of bergamot oil]. MMW.Fortschr.Med. 12-15-2005;147(51-52):53, 55.
  8. Placzek, M., Fromel, W., Eberlein, B., Gilbertz, K. P., and Przybilla, B. Evaluation of phototoxic properties of fragrances. Acta Derm.Venereol. 2007;87(4):312-316. PubMed
  9. Mollace, V., Sacco, I., Janda, E., Malara, C., Ventrice, D., Colica, C., Visalli, V., Muscoli, S., Ragusa, S., Muscoli, C., Rotiroti, D., and Romeo, F. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. F PubMed
  10. Morliere, P., Huppe, G., Averbeck, D., Young, A. R., Santus, R., and Dubertret, L. In vitro photostability and photosensitizing properties of bergamot oil. Effects of a cinnamate sunscreen. J.Photochem.Photobiol.B 1990;7(2-4):199-208. PubMed
  11. Young, A. R., Walker, S. L., Kinley, J. S., Plastow, S. R., Averbeck, D., Morliere, P., and Dubertret, L. Phototumorigenesis studies of 5-methoxypsoralen in bergamot oil: evaluation and modification of risk of human use in an albino mouse skin model. J.P PubMed
  12. Girard, J., Unkovic, J., Delahayes, J., and Lafille, C. [Phototoxicity of Bergamot oil. Comparison between humans and guinea pigs]. Dermatologica 1979;158(4):229-243.
  13. Zaynoun, S. T., Johnson, B. E., and Frain-Bell, W. A study of oil of bergamot and its importance as a phototoxic agent. II. Factors which affect the phototoxic reaction induced by bergamot oil and psoralen derivatives. Contact Dermatitis 1977;3(5):225-23 PubMed
  14. Zacher, K. D. and Ippen, H. [Contact dermatitis caused by bergamot oil]. Derm.Beruf.Umwelt. 1984;32(3):95-97.
  15. Yasui, Y. and Hirone, T. Action spectrum for bergamot-oil phototoxicity measured by sunburn cell counting. J.Dermatol. 1994;21(5):319-322. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bergamot and Sirolimus (albumin bound) Together: Common Questions

Is it safe to take Bergamot with Sirolimus (albumin bound)?
We do not list a known interaction between Bergamot and Sirolimus (albumin bound). That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Bergamot and Sirolimus (albumin bound) have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Bergamot and Sirolimus (albumin bound) combination checked?
Interactions in our licensed database are recorded against drug classes. Sirolimus (albumin bound) is filed under 4 classifications, and Bergamot has documented interactions with 2 drug classes — none of Sirolimus (albumin bound)'s classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Bergamot interact with any other medications?
Yes. Bergamot has 410 documented drug interactions in our database — Sirolimus (albumin bound) is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sirolimus (albumin bound) interact with any supplements?
Yes. Sirolimus (albumin bound) has documented interactions with 171 supplements in our database — Bergamot is not one of them. The Sirolimus (albumin bound) interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bergamot monograph Uses, safety profile, and every drug interaction in one place Sirolimus (with albumin) Injection drug information The full plain-English guide to this medication Sirolimus (albumin bound) supplement interactions Every supplement checked against Sirolimus (albumin bound), ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 17 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.