Drug & supplement interaction

Thunder God Vine + Sirolimus (albumin bound)

Sirolimus (albumin bound) brand name: Fyarro.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Sirolimus (albumin bound) falls into 2 drug categories that Thunder God Vine can interact with; the most serious is rated moderate. Theoretically, thunder god vine might increase the levels and clinical effects of CYP3A4 substrates.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Thunder God Vine and Sirolimus (albumin bound)

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Thunder God Vine interacts with whole categories of medication. Sirolimus (albumin bound) falls into 2 of those categories, so it can interact with Thunder God Vine in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

1 of 2

Why this applies to Sirolimus (albumin bound)

Sirolimus (albumin bound) falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES — the group Thunder God Vine interacts with.

Theoretically, thunder god vine might increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that triptolide, a constituent of thunder god vine, inhibits CYP3A4 enzymes in human microsomes. This interaction has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: your sirolimus (Fyarro) gets cleared from the body by a liver enzyme called CYP3A4. Thunder God Vine contains a compound (triptolide) that, in test-tube studies, appears to slow that same enzyme down. If it does the same thing in real life, your body would break sirolimus down more slowly, letting its levels creep up. That means a higher chance of side effects like mouth sores, low blood counts, infections, swelling, high blood sugar, or lung problems.

One important point: this concern comes only from lab research, not from real patients, so it's theoretical for now. Still, sirolimus is a powerful cancer drug with a narrow safety window, so I wouldn't combine these on your own. Please check with your oncology team or pharmacist first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Song W, Liu M, Wu J, Zhai H, Chen Y, Peng Z. Preclinical Pharmacokinetics of Triptolide: A Potential Antitumor Drug. Curr Drug Metab. 2019;20(2):147-154. PubMed
Moderate

IMMUNOSUPPRESSANTS

2 of 2

Sirolimus (albumin bound) also falls under IMMUNOSUPPRESSANTS.

Theoretically, thunder god vine might enhance the effects of immunosuppressant drugs.
Large doses of thunder god vine may suppress immune function.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing about pairing Thunder God Vine with Fyarro (albumin-bound sirolimus): both of them quiet down the immune system. Sirolimus already works as a kinase inhibitor that tames the immune response, and this herb (through compounds like triptolide and celastrol) seems to do something similar. Stack them together and the worry is an additive effect, meaning your immune defenses could end up more suppressed than intended.

In practical terms, that could mean a higher chance of infections, mouth sores, low blood counts, or feeling run down. I want to be upfront though: this concern is theoretical, based on how each one behaves rather than real cases. Since Fyarro is a serious cancer therapy and this herb can be toxic if dosed wrong, please loop in your oncologist or pharmacist before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Zhen QS, Ye X, Wei ZJ. Recent progress in research on Tripterygium: a male antifertility plant. Contraception 1995;51:121-9.. PubMed
  2. Chen Y, Lu M, Feng Y, Gao Q. The effect and safety of low-dose Tripterygium wilfordii in patients with type 2 diabetic nephropathy: A meta-analysis. Medicine (Baltimore) 2022;101(52):e32504. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Thunder God Vine Also Interacts With Other Medications

Thunder God Vine has 848 moderate known drug interactions in our database — the Sirolimus (albumin bound) one above is among them. If you take anything else, check it against the full list below.

Moderate 848 No known interaction 1,982 (incl. Sirolimus (albumin bound))
Taking anything else?

Check Another of Your Medications Against Thunder God Vine

Covers the 2,830 medications we’ve checked against Thunder God Vine. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Sirolimus (albumin bound)

This page covers Thunder God Vine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sirolimus (albumin bound) page lists 171 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate), Active Hexose Correlated Compound (ahcc) (moderate) and Adrafinil (moderate).

By severity: 2 major · 142 moderate · 27 minor.

From our pharmacist’s overview on the Sirolimus (albumin bound) page

“Fyarro, the albumin-bound form of sirolimus used to treat advanced malignant PEComa, a rare cancer, is a medication I would guard carefully from supplement interference, and the 171 ingredients on this page show why. Most of them (121 through the CYP3A4 enzyme, 37 through the P-glycoprotein transporter) can shift how much sirolimus act…”

Reviewed by 2 · Jul 18, 2026

Open the Sirolimus (albumin bound) interaction page

How much people look this up

Where Thunder God Vine and Sirolimus (albumin bound) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Thunder God Vine
Steady interest

#1,095 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sirolimus (albumin bound)
Top 10%

#278 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Thunder God Vine

What is Thunder God Vine?

Thunder God Vine
  • Rheumatoid arthritis
  • Lupus and autoimmune conditions
  • Inflammation
  • Skin conditions like psoriasis
  • Immune-related disorders

Thunder God Vine is a Chinese herb studied mainly for rheumatoid arthritis and other autoimmune conditions, with some promising but limited evidence. It can be toxic if prepared or dosed improperly, and may cause serious side effects, so it should only be used under medical supervision. Avoid it during pregnancy and breastfeeding.

Read the full Thunder God Vine monograph & all interactions
Medication

About Sirolimus (with albumin) Injection

What Is Sirolimus (with albumin) Injection Used For?

Brand name: Fyarro

Fyarro (sirolimus protein-bound particles for injectable suspension) is approved to treat adults with locally advanced unresectable (cannot be surgically removed) or metastatic (spread to other parts of the body) malignant perivascular epithelioid cell tumor, known as PEComa. This is a rare type of soft-tissue tumor.

See full Sirolimus (with albumin) Injection drug information
Keep checking

Other Drugs & Thunder God Vine

Browse every other medication we’ve checked against Thunder God Vine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
848Moderate
0Minor
1,981No known interaction
848 Moderate 1,981 No interaction
Moderate

848 interactions

Showing 60 of 848 moderate interactions — see all 848 on the Thunder God Vine page.

No interaction 1,981 drugs checked — show the list

We also checked Thunder God Vine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,981 medications checked with no known interaction — see the full Thunder God Vine list.

See the full Thunder God Vine interactions page
See every supplement checked against Sirolimus (albumin bound), ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Thunder God Vine monograph › Uses, safety, and every drug interaction in one place Sirolimus (albumin bound) supplement interactions › Every supplement checked against Sirolimus (albumin bound), ranked by severity Sirolimus (with albumin) Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Thunder God Vine and Sirolimus (albumin bound) Together: Common Questions

Can you take Thunder God Vine with Sirolimus (albumin bound)?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Thunder God Vine and Sirolimus (albumin bound)?
Sirolimus (albumin bound) belongs to more than one drug category, and Thunder God Vine interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Thunder God Vine and Sirolimus (albumin bound) interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.