Medication interaction hub

What Supplements Interact with Prednisolone?

Prednisolone brand names: Prednisolone, Sterane, Delta Cortef, Cortalone, Pred Forte, and others. Every interaction below applies to the brands too.

202 Interactions 4 Major 162 Moderate 36 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Prednisolone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Prednisolone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Prednisolone quiets inflammation and dampens the immune system, and its list of 202 interacting supplement and herbal ingredients, four of them rated major, deserves a careful read rather than a shrug. Grapefruit can push prednisolone levels up by blocking its breakdown, St. John's wort does the reverse and can weaken the dose, and activated charcoal can bind the drug before it absorbs. The fourth major entry pairs potassium loss from long steroid use with certain heart-active herbs, a combination that can turn toxic.

Most of the 162 moderate entries follow two patterns. More than half of the full list touches the liver enzymes and gut transporters that handle prednisolone, nudging its blood level up or down. Another 53 are herbs thought to stimulate immunity, which works directly against the reason the steroid was prescribed. Thirty-six minor entries round it out; the four majors are where I would start reading.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 162 Minor 36 No known interaction 1,250

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Prednisolone: Top Interactions at a Glance

The Prednisolone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 202 interacting ingredients — plus 1,250 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Prednisolone Combinations Today

The Prednisolone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Valerian + Prednisolonei

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Black Seed + Prednisolonei

Theoretically, black seed might interfere with immunosuppressive therapy.

Read the full interaction Moderate Likelihood Possible Kefir + Prednisolonei

Theoretically, kefir might increase the risk of bacterial and yeast infections in patients taking immunosuppressants.

Read the full interaction Moderate Likelihood Possible Oleander + Prednisolonei

Theoretically, using oleander with prolonged corticosteroid therapy can increase the risk of oleander toxicity.

Read the full interaction Moderate Likelihood Possible Maritime Pine + Prednisolonei

Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.

Read the full interaction Moderate Likelihood Possible Ginger + Prednisolonei

Ginger might increase or decrease the levels of CYP3A4 substrates.

Read the full interaction
The complete list

Every Supplement Checked Against Prednisolone

All 1,452 ingredients in our database, ranked by severity — 202 with a Prednisolone interaction on file and 1,250 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Prednisolone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Valerian with Prednisolone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.

Full Valerian + Prednisolone answer

Can you take Black Seed with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black seed might interfere with immunosuppressive therapy.

Full Black Seed + Prednisolone answer

Can you take Kefir with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kefir might increase the risk of bacterial and yeast infections in patients taking immunosuppressants.

Full Kefir + Prednisolone answer

Can you take Oleander with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using oleander with prolonged corticosteroid therapy can increase the risk of oleander toxicity.

Full Oleander + Prednisolone answer

Can you take Maritime Pine with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.

Full Maritime Pine + Prednisolone answer

Can you take Andrographis with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, andrographis might interfere with the effects of immunosuppressive drugs.

Full Andrographis + Prednisolone answer

Can you take Ashwagandha with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.

Full Ashwagandha + Prednisolone answer

Can you take Astaxanthin with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astaxanthin may decrease levels of drugs metabolized by CYP3A4.

Full Astaxanthin + Prednisolone answer

Can you take Astragalus with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, astragalus might interfere with immunosuppressive therapy.

Full Astragalus + Prednisolone answer

Can you take Ayahuasca with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, ayahuasca might increase plasma concentrations of CYP3A4 substrates.

Full Ayahuasca + Prednisolone answer

Can you take Bacopa with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.

Full Bacopa + Prednisolone answer

Can you take Bee Venom with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bee venom might stimulate immune system activity.Theoretically, bee venom might interfere with immunosuppressant therapy.

Full Bee Venom + Prednisolone answer

Can you take Beet with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Prednisolone answer

Can you take Berberine with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.

Full Berberine + Prednisolone answer

Can you take Beta-glucans with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beta-glucans might interfere with immunosuppressive therapy.

Full Beta-glucans + Prednisolone answer

Can you take Beta-methylphenethylamine (bmpea) with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, BMPEA might increase the levels and clinical effects of CYP3A4 substrates.

Full Beta-methylphenethylamine (bmpea) + Prednisolone answer

Can you take Bishop's Weed with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bergapten, a constituent of bishop's weed, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Bishop's Weed + Prednisolone answer

Can you take Bitter Melon with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter melon might increase levels of P-glycoprotein substrates.

Full Bitter Melon + Prednisolone answer

Can you take Bitter Orange with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bitter orange might increase levels of drugs metabolized by CYP3A4.

Full Bitter Orange + Prednisolone answer

Can you take Black Hoof Mushroom with Prednisolone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black hoof mushroom might reduce the effects of immunosuppressant medications.

Full Black Hoof Mushroom + Prednisolone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Prednisolone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Prednisolone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Prednisolone sits in 6 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Prednisolone through this category.

Immunosuppressants 53 ingredients

Medications that damp down the immune system. Supplements that stimulate immunity can work against them.

53 of the supplement ingredients on this page reach Prednisolone through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Prednisolone through this category.

Corticosteroids 18 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

18 of the supplement ingredients on this page reach Prednisolone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Prednisolone through this category.

Prednisolone 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Prednisolone through this category.

About Prednisolone

Prednisolone is a corticosteroid used to treat low corticosteroid levels, inflammation, immune system disorders, and prevent transplant rejection.

Generic name: Prednisolone  ·  Brand names: Prednisolone, Sterane, Delta Cortef, Cortalone, Pred Forte, Solupred.

See the full Prednisolone drug information

Related: does Prednisolone deplete any nutrients?

Prednisolone has 40 reported nutrient associations in the research literature — see the Prednisolone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Prednisolone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Prednisolone.

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Pharmacist Counseling Corner

Prednisolone & Supplements: Common Questions

What supplements interact with Prednisolone?
Our database currently documents 202 ingredients with a known Prednisolone interaction (4 major, 162 moderate, 36 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 202. The highest-ranked right now: Grapefruit, Activated Charcoal, Lily-of-the-valley.
Which Prednisolone supplement interactions are the most serious?
The 4 major-rated combinations — led by Grapefruit, Activated Charcoal, Lily-of-the-valley and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Prednisolone?
Plenty of supplements coexist fine with Prednisolone; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Prednisolone have the same supplement interactions as Prednisolone?
Yes — Prednisolone, Sterane, Delta Cortef, Cortalone, Pred Forte and other brands all contain Prednisolone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Prednisolone deplete any vitamins or nutrients?
It might — Prednisolone has 40 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Prednisolone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Prednisolone and my other medications?
This page covers Prednisolone against supplements and herbal ingredients. Checking Prednisolone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Prednisolone drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.