Barley + Prednisolone
Prednisolone brand names: Prednisolone, Sterane, Delta Cortef, Cortalone, Pred Forte, and others.
We found no known interaction between Barley and Prednisolone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Barley and Prednisolone
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Prednisolone and Barley in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Barley safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Prednisolone
Interactions in our licensed database are recorded against drug classes, not just single drug names. Prednisolone is filed under 6 classifications — including corticosteroids, immunosuppressants, p-glycoprotein substrates. Barley has documented interactions with 1 drug class — the most serious being triclabendazole (egaten) (moderate) — and none of Prednisolone’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Barley Does Interact With Other Medications
Barley has 1 moderate known drug interaction in our database — Prednisolone isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Barley
We haven’t checked that one against Barley yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Barley. Pick one to open its full report.
Barley in Pregnancy & Breastfeeding
When used orally in amounts commonly found in foods.
When barley sprouts are consumed in relatively high doses. Excessive amounts of barley sprouts should not be consumed during pregnancy.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
What Prednisolone Is Prescribed For, and What Barley Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Prednisolone is a prescription medicine with approved uses on its FDA label. Barley is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Prednisolone is prescribed for: Prednisolone is prescribed for many different conditions where inflammation or an overactive immune system is causing harm. These range from severe allergic reactions and asthma to certain skin diseases, blood disorders, eye problems, and some cancers. It is also used to support the body when the adrenal glands aren't making enough of their own steroids, and to manage flares of conditions like ulcerative colitis, multiple sclerosis, and nephrotic syndrome (a kidney condition causing protein loss in the urine).
Barley has been studied for:
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Ulcerative colitis studied, not established Barley has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Barley for ulcerative colitis
Small clinical studies suggest that oral barley might improve symptoms associated with ulcerative colitis.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Prednisolone on your own; if you are taking Barley for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
Questions About Barley or Prednisolone
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Barley or Prednisolone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Question Regarding Dosing Prednisolone Eye Drops Four Times Daily ›
- Can You Drink Alcohol If Using Medicated Eye Drops? ›
- Can You Take Prednisone With Zarbee's Cough? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Prednisolone
This page covers Barley only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Prednisolone page lists 202 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lily-of-the-valley (major), St. John's Wort (major) and Acacia Rigidula (moderate).
By severity: 4 major · 162 moderate · 36 minor.
From our pharmacist’s overview on the Prednisolone page
“Prednisolone quiets inflammation and dampens the immune system, and its list of 202 interacting supplement and herbal ingredients, four of them rated major, deserves a careful read rather than a shrug. Grapefruit can push prednisolone levels up by blocking its breakdown, St.”
Reviewed by 2 · Jul 18, 2026
Taking Barley as Part of a Dietary Supplement Product? Check It for Interactions
We hold 2,448 real supplement products containing Barley, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Barley. Even though Barley itself has no known interaction with Prednisolone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Barley and Prednisolone Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#163 of 1,452 supplements looked up here in the last 7 days
#517 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Barley reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Barley and Prednisolone records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Barley
What is Barley?
- High cholesterol
- Heart health support
- Blood sugar support
- Digestive regularity and fiber
- General nutrition
Barley is a nutritious whole grain that is a good source of soluble fiber called beta-glucan, which has solid evidence for modestly lowering LDL ('bad') cholesterol when eaten regularly. It is safe as a food for most people, but those with celiac disease or gluten sensitivity should avoid it since it contains gluten. Talk to your pharmacist or doctor before using concentrated barley supplements, especially if you have a health condition.
Hordeum vulgare · Poaceae · Grain (seed), and sometimes young leaves/grass and bran · Whole grain, flour, flakes, barley bran, beta-glucan supplements, barley grass powder, tea, and capsules
An interaction check asks whether these two react with each other — it does not ask whether Barley is a good idea for someone in your situation. Here is what our Barley record says about it on its own.
Barley: dosing
There is no single official supplement dose for barley. For cholesterol benefits, research has generally used a few grams of barley beta-glucan per day, taken as part of the diet, but the exact amount can vary by product.Because products differ widely in strength and form, the best approach is to follow the directions on the product label.
From our Barley monograph — the full record covers uses, side effects and every documented interaction.
About Prednisolone
What Is Prednisolone Used For?
Brand names: Prednisolone, Sterane, Delta Cortef, Cortalone, Pred Forte, Solupred
Prednisolone is prescribed for many different conditions where inflammation or an overactive immune system is causing harm. These range from severe allergic reactions and asthma to certain skin diseases, blood disorders, eye problems, and some cancers.
It is also used to support the body when the adrenal glands aren't making enough of their own steroids, and to manage flares of conditions like ulcerative colitis, multiple sclerosis, and nephrotic syndrome (a kidney condition causing protein loss in the urine).
Most-Reported Side Effects for Prednisolone
From FAERS, the FDA’s public side-effect reporting system (191,421 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Barley
Browse every other medication we’ve checked against Barley — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1 interaction
No interaction 2,828 drugs checked — show the list
We also checked Barley against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Losartan Potassium ›
- Testosterone ›
- Ivermectin ›
- Aspirin ›
- Abemaciclib ›
- Metoprolol ›
- Acetaminophen ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Valacyclovir ›
- Warfarin Sodium ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Barley list.
Barley References
The 15 references that drive our Barley monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Fernandez-Anaya S, Crespo JF, Rodriguez JR, et al. Beer anaphylaxis. J Allergy Clin Immunol 1999;103:959-60.
- Lembo A, Camilleri M. Chronic constipation. N Engl J Med 2003;349:1360-8. . PubMed
- Ferre, I., Giraldez, F. J., Alvarez-Bujidos, M. L., and Mantecon, A. R. Influence of barley supplement on plasma concentration of triclabendazole metabolites in sheep. Vet.Rec. 11-22-1997;141(21):549-551. PubMed
- Curioni, A., Santucci, B., Cristaudo, A., Canistraci, C., Pietravalle, M., Simonato, B., and Giannattasio, M. Urticaria from beer: an immediate hypersensitivity reaction due to a 10- kDa protein derived from barley. Clin Exp Allergy 1999;29(3):407-413. PubMed
- Fernandez-Anaya, S., Crespo, J. F., Rodriguez, J. R., Daroca, P., Carmona, E., Herraez, L., and Lopez-Rubio, A. Beer anaphylaxis. J Allergy Clin Immunol. 1999;103(5 Pt 1):959-960.
- Cronin, E. Contact dermatitis from barley dust. Contact Dermatitis 1979;5(3):196. PubMed
- Block, G., Tse, K. S., Kijek, K., Chan, H., and Chan-Yeung, M. Baker's asthma. Studies of the cross-antigenicity between different cereal grains. Clin Allergy 1984;14(2):177-185.
- van Ketel, W. G. Immediate type allergy to malt in beer. Contact Dermatitis 1980;6(4):297-298. PubMed
- Ellis, H. J., Doyle, A. P., Day, P., Wieser, H., and Ciclitira, P. J. Demonstration of the presence of coeliac-activating gliadin-like epitopes in malted barley. Int Arch Allergy Immunol. 1994;104(3):308-310. PubMed
- Vidal, C. and Gonzalez-Quintela, A. Food-induced and occupational asthma due to barley flour. Ann Allergy Asthma Immunol. 1995;75(2):121-124.
- Gutgesell, C. and Fuchs, T. Contact urticaria from beer. Contact Dermatitis 1995;33(6):436-437. PubMed
- Baker, P. G. and Read, A. E. Oats and barley toxicity in coeliac patients. Postgrad.Med J 1976;52(607):264-268. PubMed
- Nakase, M., Usui, Y., Alvarez-Nakase, A. M., Adachi, T., Urisu, A., Nakamura, R., Aoki, N., Kitajima, K., and Matsuda, T. Cereal allergens: rice-seed allergens with structural similarity to wheat and barley allergens. Allergy 1998;53(46 Suppl):55-57. PubMed
- Pereira, F., Rafael, M., and Lacerda, M. H. Contact dermatitis from barley. Contact Dermatitis 1998;39(5):261-262. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Prednisolone Is Linked to Lower Levels of 8 Nutrients
Natural Medicines records Prednisolone as a medicine that can lower these. This is not an interaction with Barley — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Prednisolone nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Barley and Prednisolone Together: Common Questions
Is it safe to take Barley with Prednisolone?
Do Barley and Prednisolone have any of the same side effects?
Are Barley and Prednisolone used for the same thing?
How was the Barley and Prednisolone combination checked?
Does Barley interact with any other medications?
Does Prednisolone interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.