Drug & supplement interaction

American Dogwood + Donepezil

Donepezil brand name: Aricept.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between American Dogwood and Donepezil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

American Dogwood and Donepezil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Donepezil and American Dogwood in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for American Dogwood at all — not against Donepezil, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

American Dogwood safety at a glance

American Dogwood overall Not established Human safety data are very limited, so it cannot be considered well-established as safe.
Pregnancy Avoid Not enough safety information exists, so it is best avoided during pregnancy.
Breastfeeding Avoid No reliable safety data are available, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Donepezil and American Dogwood? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Donepezil’s Own FDA Label Lists

This is not an interaction — none of it involves American Dogwood. These are the most notable effects listed in the ADVERSE REACTIONS section of Donepezil’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • Bleeding in the gut Worth acting on
  • Seizures Worth acting on
  • Bleeding or bruising Worth acting on
  • Weight loss
  • Reduced appetite
  • Muscle pain
  • Trouble sleeping
  • Tiredness mentioned in 4.8% of FDA reports for Donepezil
  • Diarrhea mentioned in 5.0% of FDA reports for Donepezil
  • Nausea mentioned in 4.6% of FDA reports for Donepezil

Showing the 10 most notable of 11 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Donepezil. Read the label on DailyMed › Where a percentage is shown, it is the share of 37,026 voluntary FDA FAERS reports for Donepezil that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. American Dogwood’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no American Dogwood side to compare — that is a limit of the record, not a statement that American Dogwood has no side effects.

From our Q&A

Questions About American Dogwood or Donepezil

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers American Dogwood or Donepezil, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Donepezil

This page covers American Dogwood only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Donepezil page lists 173 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), 1,3-dmaa (moderate) and Acacia Rigidula (moderate).

By severity: 3 major · 127 moderate · 43 minor.

From our pharmacist’s overview on the Donepezil page

“If you or a loved one takes donepezil (Aricept) for Alzheimer's disease, this is a list worth reading with real care, starting with the three major-rated entries: grapefruit, St. John's wort, and activated charcoal.”

Reviewed by 2 · Jul 18, 2026

Open the Donepezil interaction page

One more smart check

Taking American Dogwood as Part of a Dietary Supplement Product? Check It for Interactions

We hold 12 real supplement products containing American Dogwood, each one broken down to its full ingredient list — and combination products often carry several ingredients besides American Dogwood. Even though American Dogwood itself has no known interaction with Donepezil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where American Dogwood and Donepezil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement American Dogwood
Steady interest

#1,425 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Donepezil
Steady interest

#1,623 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. American Dogwood is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every American Dogwood reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The American Dogwood and Donepezil records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About American Dogwood

What is American Dogwood?

American Dogwood
  • Fever
  • Pain and inflammation
  • Digestive upset
  • Skin and wound care (traditional)
  • General tonic

American Dogwood is a North American flowering tree whose bark was used in traditional folk medicine, especially as a substitute for quinine to treat fevers. There is very little modern human research to support any health use, and it is rarely found in supplements today. Talk with a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Cornus florida · Cornaceae · Bark (and sometimes leaves and berries) · Dried bark, tea, tincture, occasional capsules

An interaction check asks whether these two react with each other — it does not ask whether American Dogwood is a good idea for someone in your situation. Here is what our American Dogwood record says about it on its own.

American Dogwood: dosing

There is no established or standardized dose for American Dogwood. It is rarely sold as a commercial supplement, and reliable dosing guidelines from human studies do not exist.If you are considering a product that contains American Dogwood, follow the directions on the label and do not exceed them.

From our American Dogwood monograph — the full record covers uses, side effects and every documented interaction.

Read the full American Dogwood monograph & all interactions
Medication

About Donepezil

What Is Donepezil Used For?

Brand name: Aricept

Donepezil is used to treat dementia of the Alzheimer's type. It has been shown to be effective across all stages — mild, moderate, and severe Alzheimer's disease.

It can help with memory, thinking, and daily functioning, though it works differently for each person. Donepezil does not cure Alzheimer's disease or stop the disease from progressing.

Most-Reported Side Effects for Donepezil

From FAERS, the FDA’s public side-effect reporting system (37,026 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fall 3,130 reports
Confusional state 2,010 reports
Dizziness 1,857 reports
Diarrhea 1,840 reports
Fatigue 1,794 reports
See full Donepezil drug information
Keep checking

Other Drugs & American Dogwood

Browse every other medication we’ve checked against American Dogwood — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked American Dogwood against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full American Dogwood list.

See the full American Dogwood interactions page
See every supplement checked against Donepezil, ranked by severity
Evidence & sources

American Dogwood References

The 1 sources that drive our American Dogwood monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. American Dogwood is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking American Dogwood and Donepezil Together: Common Questions

Is it safe to take American Dogwood with Donepezil?
We do not list a known interaction between American Dogwood and Donepezil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Donepezil interact with any supplements?
Yes. Donepezil has documented interactions with 173 supplements in our database — American Dogwood is not one of them. The Donepezil interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

American Dogwood monograph Uses, safety profile, and every drug interaction in one place Donepezil drug information The full plain-English guide to this medication Donepezil supplement interactions Every supplement checked against Donepezil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Donepezil and American Dogwood?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.