American White Water Lily + Tofacitinib
Tofacitinib brand names: Xeljanz, Xeljanz XR.
We found no known interaction between American White Water Lily and Tofacitinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
American White Water Lily and Tofacitinib
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Tofacitinib and American White Water Lily in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for American White Water Lily at all — not against Tofacitinib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
American White Water Lily safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Tofacitinib
This page covers American White Water Lily only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tofacitinib page lists 184 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Active Hexose Correlated Compound (ahcc) (moderate).
By severity: 3 major · 143 moderate · 38 minor.
From our pharmacist’s overview on the Tofacitinib page
“Supplements deserve genuine care alongside tofacitinib (Xeljanz, Xeljanz XR), a medicine that deliberately dials down the immune system to control conditions like rheumatoid arthritis and ulcerative colitis. Most of the interactions on this page run through the liver enzymes that clear the drug, meaning an herb can push its blood level…”
Reviewed by 2 · Jul 18, 2026
Where American White Water Lily and Tofacitinib Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#835 of 1,452 supplements looked up here in the last 7 days
#2,193 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. American White Water Lily is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every American White Water Lily reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The American White Water Lily and Tofacitinib records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About American White Water Lily
What is American White Water Lily?
- Sore throat and mouth irritation
- Vaginal irritation (as a wash or douche)
- Skin sores, burns, and boils (topical poultice)
- Diarrhea (astringent)
- Minor wound care
American white water lily is a North American aquatic plant whose root has a long history of traditional use, mostly as an astringent for skin, mouth, and vaginal complaints. There is very little modern human research to confirm any of these uses, so it should be viewed as a folk remedy rather than a proven treatment. Talk to your pharmacist or doctor before using it, and avoid it if you are pregnant or breastfeeding.
Nymphaea odorata · Nymphaeaceae · Rhizome (root) and flowers; sometimes leaves · Dried root, powder, tea, liquid extract, poultice, and topical washes or gargles
An interaction check asks whether these two react with each other — it does not ask whether American White Water Lily is a good idea for someone in your situation. Here is what our American White Water Lily record says about it on its own.
American White Water Lily: dosing
There is no established standard dose for American white water lily. Traditional use involved preparing the root as a tea, wash, gargle, or poultice, but exact amounts were not standardized and varied widely.If you choose to use a commercial product, follow the directions on the label and do not exceed them.
From our American White Water Lily monograph — the full record covers uses, side effects and every documented interaction.
About Tofacitinib
What Is Tofacitinib Used For?
Brand names: Xeljanz, Xeljanz XR
Tofacitinib is used in adults with moderately to severely active rheumatoid arthritis, active psoriatic arthritis, active ankylosing spondylitis, and moderately to severely active ulcerative colitis. In each case it is for people who did not respond well to, or could not tolerate, one or more TNF blockers.
Xeljanz and tofacitinib tablets and oral solution are also used in children 2 years and older with active psoriatic arthritis or active polyarticular course juvenile idiopathic arthritis (arthritis in multiple joints). Extended-release tablets are labeled for adults only.
Most-Reported Side Effects for Tofacitinib
From FAERS, the FDA’s public side-effect reporting system (186,746 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & American White Water Lily
Browse every other medication we’ve checked against American White Water Lily — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked American White Water Lily against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Ivermectin ›
- Abemaciclib ›
- Testosterone ›
- Losartan Potassium ›
- Sertraline ›
- Acetaminophen ›
- Rosuvastatin ›
- Aspirin ›
- Escitalopram ›
- Metoprolol ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Tirzepatide ›
- Ibuprofen ›
- Warfarin Sodium ›
- Amlodipine Besylate ›
- Methamphetamine ›
- Levothyroxine, Liothyronine ›
- Docusate ›
- Prednisone ›
- Metformin ›
- Amitriptyline ›
- Valacyclovir ›
- Tadalafil ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Lisdexamfetamine ›
- Amphetamine ›
- Propranolol ›
- Methotrexate ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Pregabalin ›
- Doxycycline ›
- Gabapentin ›
- Dextroamphetamine ›
- Bendamustine ›
- Acetaminophen, Aspirin, Caffeine ›
- Naproxen ›
- Lamotrigine ›
- Quetiapine ›
- Acyclovir ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Citalopram ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full American White Water Lily list.
American White Water Lily References
The 1 sources that drive our American White Water Lily monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. American White Water Lily is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.
- Using Dietary Supplements Wisely — NIH NCCIH Source
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking American White Water Lily and Tofacitinib Together: Common Questions
Is it safe to take American White Water Lily with Tofacitinib?
Does Tofacitinib interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.