Angostura + Leniolisib
Leniolisib brand name: Joenja.
We found no known interaction between Angostura and Leniolisib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Angostura and Leniolisib
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Leniolisib and Angostura in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Angostura at all — not against Leniolisib, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Angostura safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
See Every Supplement That Interacts With Leniolisib
This page covers Angostura only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Leniolisib page lists 145 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).
By severity: 3 major · 100 moderate · 42 minor.
From our pharmacist’s overview on the Leniolisib page
“Leniolisib (Joenja) treats APDS, a rare immune disorder, and it is cleared by the CYP3A4 enzyme, a pathway that runs through nearly this whole page: 121 of the 145 supplements and herbs on file can push its blood level up or down that way. That deserves genuine vigilance, starting with the three major entries.”
Reviewed by 2 · Jul 18, 2026
Taking Angostura as Part of a Dietary Supplement Product? Check It for Interactions
We hold 1 real supplement products containing Angostura, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Angostura. Even though Angostura itself has no known interaction with Leniolisib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Angostura and Leniolisib Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,154 of 1,452 supplements looked up here in the last 7 days
#942 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Angostura reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Angostura and Leniolisib records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Angostura
What is Angostura?
- Digestive upset and poor appetite
- Fever
- Diarrhea
- Malaria prevention (traditional)
- Muscle spasms
Angostura is the bark of a South American tree traditionally used to ease digestion, fevers, and stomach problems. Modern human evidence to support these uses is very limited, and large doses can cause vomiting and other harmful effects. It is best known today as a historic flavoring ingredient, and you should talk with a pharmacist or doctor before using it medicinally.
Angostura trifoliata · Rutaceae · Bark · Bark powder, tincture, extract, and as a flavoring in some alcoholic beverages
An interaction check asks whether these two react with each other — it does not ask whether Angostura is a good idea for someone in your situation. Here is what our Angostura record says about it on its own.
Angostura: dosing
There is no well-established, standardized medicinal dose for angostura. Traditional uses vary widely, and there is not enough reliable research to recommend a safe and effective amount.If you choose to use a product that contains angostura, follow the directions on the product label and do not exceed them, since larger amounts can cause vomiting and diarrhea.
From our Angostura monograph — the full record covers uses, side effects and every documented interaction.
About Leniolisib
What Is Leniolisib Used For?
Brand name: Joenja
Joenja (leniolisib) is approved to treat activated phosphoinositide 3-kinase delta syndrome, commonly called APDS — a rare genetic immune disorder in which certain immune cells (B and T cells) don't work properly. It is approved for adults and pediatric patients who are at least 12 years old.
APDS is caused by gene variants that make a specific enzyme (PI3K-delta) overactive, leading to immune system dysfunction. Joenja is the brand name for leniolisib in tablet form, taken by mouth.
Other Drugs & Angostura
Browse every other medication we’ve checked against Angostura — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Angostura against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Valacyclovir ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Angostura list.
Angostura References
The 2 references that drive our Angostura monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Angostura and Leniolisib Together: Common Questions
Is it safe to take Angostura with Leniolisib?
Does Leniolisib interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Leniolisib and Angostura?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.