Drug & supplement interaction

Antioxidants + Prochlorperazine

Prochlorperazine brand names: Prochlor, Compazine.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Antioxidants and Prochlorperazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Antioxidants and Prochlorperazine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Prochlorperazine and Antioxidants in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Antioxidants at all — not against Prochlorperazine, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Antioxidants safety at a glance

Antioxidants overall Use caution Antioxidants from food are very safe, but high-dose supplements may carry risks for some people.
Pregnancy Possibly Safe When certain antioxidants are used orally and appropriately during pregnancy. See monographs of specific ingredients for more information. Read the full pregnancy detail
Breastfeeding Use caution Dietary amounts are fine, but check with your doctor before taking high-dose supplements.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Prochlorperazine and Antioxidants? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Prochlorperazine’s Own FDA Label Lists

This is not an interaction — none of it involves Antioxidants. These are the most notable effects listed in the ADVERSE REACTIONS section of Prochlorperazine’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Dependence or withdrawal symptoms Worth acting on
  • A bowel blockage Worth acting on
  • Trouble passing urine Worth acting on
  • Low blood sugar Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • High blood sugar Worth acting on
  • Wheezing Worth acting on
  • Seizures Worth acting on
  • Low mood Worth acting on
  • Anemia Worth acting on

Showing the 10 most notable of 40 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Prochlorperazine. Read the label on DailyMed › Antioxidants’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Antioxidants side to compare — that is a limit of the record, not a statement that Antioxidants has no side effects.

Special populations

Antioxidants in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When certain antioxidants are used orally and appropriately during pregnancy. See monographs of specific ingredients for more information.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Prochlorperazine Is Prescribed For, and What Antioxidants Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Prochlorperazine is a prescription medicine with approved uses on its FDA label. Antioxidants is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Prochlorperazine is prescribed for: Prochlorperazine is used across several forms and products to control severe nausea and vomiting in adults. It is also used to treat schizophrenia. Prochlorperazine tablets (Prochlorperazine, Prochlorperazine Maleate) are additionally approved for the short-term treatment of generalized non-psychotic anxiety — though they are not the first-choice treatment for anxiety, given their risk profile. Compro rectal suppositories and Prochlorperazine rectal suppositories are specifically indicated for controlling severe nausea and vomiting in adults.

Read the rest of what Prochlorperazine is prescribed for

Prochlorperazine Edisylate injection is approved for severe nausea and vomiting and for schizophrenia, but it is not approved for dementia-related psychosis.

Antioxidants has been studied for:

  • Schizophrenia studied, not established Antioxidants has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Antioxidants for schizophrenia

    Several small clinical studies suggest that oral antioxidants might improve psychotic symptoms, but not overall symptoms, in patients with schizophrenia.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Prochlorperazine on your own; if you are taking Antioxidants for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Prochlorperazine

This page covers Antioxidants only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Prochlorperazine page lists 96 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Indian Snakeroot (major), Rauvolfia Vomitoria (major) and Scopolia (major).

By severity: 5 major · 67 moderate · 24 minor.

Open the Prochlorperazine interaction page

How much people look this up

Where Antioxidants and Prochlorperazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Antioxidants
Steady interest

#1,230 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Prochlorperazine
Steady interest

#1,619 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Antioxidants reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Antioxidants and Prochlorperazine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Antioxidants

What is Antioxidants?

  • General wellness and aging
  • Heart health support
  • Eye health
  • Immune support
  • Skin health

Antioxidants are compounds—like vitamins C and E, selenium, and many plant chemicals—that help protect your cells from a type of damage called oxidative stress. Getting them from a varied diet of fruits and vegetables is clearly healthy, but high-dose antioxidant supplements have shown disappointing or even harmful results in some large studies. For most people, food is the safest and best source.

Capsules, tablets, softgels, powders, and foods (fruits, vegetables, nuts)

An interaction check asks whether these two react with each other — it does not ask whether Antioxidants is a good idea for someone in your situation. Here is what our Antioxidants record says about it on its own.

Antioxidants: dosing

There is no single "antioxidant dose" because the term covers many different nutrients and plant compounds. For vitamins and minerals, established recommended daily amounts and upper limits exist (set by health authorities), and exceeding the upper limit can be unsafe.The best general approach is to get antioxidants from a varied diet rather than pills.

From our Antioxidants monograph — the full record covers uses, side effects and every documented interaction.

Read the full Antioxidants monograph & all interactions
Medication

About Prochlorperazine

What Is Prochlorperazine Used For?

Brand names: Prochlor, Compazine

Prochlorperazine is used across several forms and products to control severe nausea and vomiting in adults. It is also used to treat schizophrenia. Prochlorperazine tablets (Prochlorperazine, Prochlorperazine Maleate) are additionally approved for the short-term treatment of generalized non-psychotic anxiety — though they are not the first-choice treatment for anxiety, given their risk profile.

Compro rectal suppositories and Prochlorperazine rectal suppositories are specifically indicated for controlling severe nausea and vomiting in adults. Prochlorperazine Edisylate injection is approved for severe nausea and vomiting and for schizophrenia, but it is not approved for dementia-related psychosis.

Most-Reported Side Effects for Prochlorperazine

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 4,813 reports
Fatigue 4,188 reports
Diarrhea 3,437 reports
Vomiting 2,631 reports
Febrile neutropenia 2,077 reports
See full Prochlorperazine drug information
Keep checking

Other Drugs & Antioxidants

Browse every other medication we’ve checked against Antioxidants — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Antioxidants against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Antioxidants list.

See the full Antioxidants interactions page
See every supplement checked against Prochlorperazine, ranked by severity
Evidence & sources

Antioxidants References

The 1 references that drive our Antioxidants monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Tenório MB, Ferreira RC, Moura FA, Bueno NB, Goulart MOF, Oliveira ACM. Oral antioxidant therapy for prevention and treatment of preeclampsia: Meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2018 Sep;28(9):865-876. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Antioxidants and Prochlorperazine Together: Common Questions

Is it safe to take Antioxidants with Prochlorperazine?
We do not list a known interaction between Antioxidants and Prochlorperazine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Antioxidants and Prochlorperazine used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Antioxidants in each. That is a conversation for your prescriber, especially if Prochlorperazine is being adjusted to a target.
Does Prochlorperazine interact with any supplements?
Yes. Prochlorperazine has documented interactions with 96 supplements in our database — Antioxidants is not one of them. The Prochlorperazine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Antioxidants monograph Uses, safety profile, and every drug interaction in one place Prochlorperazine drug information The full plain-English guide to this medication Prochlorperazine supplement interactions Every supplement checked against Prochlorperazine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Prochlorperazine and Antioxidants?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.