Drug & supplement interaction

Apoaequorin + Psyllium (OTC drug)

Psyllium (OTC drug) brand name: Metamucil.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Apoaequorin and Psyllium (OTC drug) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Apoaequorin and Psyllium (OTC drug)

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Psyllium (OTC drug) and Apoaequorin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Apoaequorin at all — not against Psyllium (OTC drug), and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Apoaequorin safety at a glance

Apoaequorin overall Use caution Generally well tolerated in short-term studies, but long-term safety is not well established.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid There is not enough safety information, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Pharmacist analysis
Prevagen bottle

Based on the current research available, apoaequorin, the protein derived from jellyfish that is the active ingredient in Prevagen, is not known to interact with any drugs.

This lack of interactions is likely due to the fact that apoaequorin is a relatively small and simple protein that does not have any known drug-binding sites or enzymatic activity.

Additionally, safety studies in animals have shown that even very large doses of apoaequorin don't appear to affect any organs or blood chemistry.

However, overall, there is limited data on its potential interactions with other drugs.

If someone is taking apoaequorin as a dietary supplement, they should still consult with a healthcare professional before starting to take it, especially if they are currently taking any medications or have any underlying medical conditions.

As with any dietary supplement, it is important to follow recommended dosages and to use it only as directed.

References

  • Subchronic toxicity of lyophilized apoaequorin protein powder in Sprague-Dawley rats. Sage Journals
  • Safety assessment of Apoaequorin, a protein preparation: subchronic toxicity study in rats. PubMed

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Still wondering about combining Psyllium (OTC drug) and Apoaequorin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Apoaequorin Itself Has Been Linked To

This is not an interaction — nothing below involves Psyllium (OTC drug). It is the side-effect record for Apoaequorin on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Apoaequorin, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Memory problems Worth acting on Additional detail

    “Orally, a specific apoaequorin product (Prevagen, Quincy Bioscience) has been reported to cause headache and dizziness in one clinical study at a rate of 18.8% and 7.6%, respectively. Memory impairment and insomnia were also reported. However, it is unclear how these rates compare with placebo.”

    Apoaequorin · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 89624. GRAS Notice (GRN) No. 568. U.S. Food and Drug Administration Web site. Available at: http://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/UCM457034.pdf. Accessed September 28, 2015.
  • Chest pain / Raised blood pressure Worth acting on Additional detail

    “Orally, a specific apoaequorin product (Prevagen, Quincy Bioscience) has been reported to cause hypertension, hypotension, chest pain, and irregular heart rate, but it is unclear if these events were due to apoaequorin.”

    Apoaequorin · Natural Medicines adverse-effect record, reported in hypertension.

    1 source cited
    1. 89624. GRAS Notice (GRN) No. 568. U.S. Food and Drug Administration Web site. Available at: http://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/UCM457034.pdf. Accessed September 28, 2015.
  • Low blood pressure Additional detail

    Recorded for Apoaequorin in the same Natural Medicines adverse-effect record shown under Chest pain / Raised blood pressure above.

  • Anxiety or restlessness Additional detail

    “Orally, a specific apoaequorin product (Prevagen, Quincy Bioscience) was reported to cause mild anxiety in one clinical study.”

    Apoaequorin · Natural Medicines adverse-effect record, reported in anxiety.

    1 source cited
    1. 89624. GRAS Notice (GRN) No. 568. U.S. Food and Drug Administration Web site. Available at: http://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/UCM457034.pdf. Accessed September 28, 2015.
  • Trouble sleeping Additional detail

    Recorded for Apoaequorin in the same Natural Medicines adverse-effect record shown under Memory problems above.

  • Stomach pain / Diarrhea Additional detail

    “Orally, a specific apoaequorin product (Prevagen, Quincy Bioscience) was reported to cause mild diarrhea, nausea, and stomach pain in one study. Nausea occurred at a rate of 6.8%, diarrhea at a rate of 3.2%, and stomach pain at a rate of 2.2%. However, it is unclear how these rates compare with placebo.”

    Apoaequorin · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 89624. GRAS Notice (GRN) No. 568. U.S. Food and Drug Administration Web site. Available at: http://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/UCM457034.pdf. Accessed September 28, 2015.
  • Dizziness / Headache Additional detail

    “Orally, apoaequorin seems to be well tolerated.

    Most Common Adverse Effects:

    Orally: Dizziness, headache, and nausea.”

    Apoaequorin · Natural Medicines adverse-effect record, reported in cluster headache.

Showing the 10 most notable of 11 recorded effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

Everything above comes from the Natural Medicines adverse-effect record for Apoaequorin — expand a row for the licensed statement it rests on. We haven’t matched Psyllium (OTC drug) to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Psyllium (OTC drug).

From our Q&A

Questions About Apoaequorin or Psyllium (OTC drug)

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Apoaequorin or Psyllium (OTC drug), not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Psyllium (OTC drug)

This page covers Apoaequorin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Psyllium (OTC drug) page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Psyllium (OTC drug) page

“Activated charcoal tops the psyllium (Metamucil) list and is the one entry rated major. Charcoal binds many medicines in the gut and can cut how much of them reaches the body, so pairing it with anything you take by mouth deserves real caution, and I would read that entry before the rest.”

Reviewed by 2 · Jul 18, 2026

Open the Psyllium (OTC drug) interaction page

One more smart check

Taking Apoaequorin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 28 real supplement products containing Apoaequorin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Apoaequorin. Even though Apoaequorin itself has no known interaction with Psyllium (OTC drug), another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Apoaequorin and Psyllium (OTC drug) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Apoaequorin
Steady interest

#1,076 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Psyllium (OTC drug)
Top 25%

#511 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Apoaequorin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Apoaequorin and Psyllium (OTC drug) records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Apoaequorin

What is Apoaequorin?

Apoaequorin
  • Age-related memory concerns
  • General cognitive support
  • Brain health
  • Mild forgetfulness

Apoaequorin is a jellyfish-derived protein marketed (as Prevagen) to support memory and brain health. The scientific evidence that it improves memory is weak and largely comes from industry-funded studies, and as a protein it is likely broken down during digestion. Talk with your pharmacist or doctor before using it, especially if you have memory problems that need medical evaluation.

A synthetic version of a protein originally found in the jellyfish Aequorea victoria · Capsules, chewable tablets

An interaction check asks whether these two react with each other — it does not ask whether Apoaequorin is a good idea for someone in your situation. Here is what our Apoaequorin record says about it on its own.

Apoaequorin: dosing

There is no officially established or standardized dose for apoaequorin. Taking more than the labeled amount has no proven benefit and is not recommended.

From our Apoaequorin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Apoaequorin monograph & all interactions
Medication

About Psyllium

What Is Psyllium Used For?

Brand name: Metamucil

Psyllium is used to treat occasional constipation and help restore regularity. It is available under many brand names — including Careone, Best Choice, Premier Value Fiber, fiber laxative, meijer fiber laxative, Publix, Best Choice Fiber Therapy, Daily Fiber, Dr. Fibra, Lidl Orange Smooth Fiber Powder, and meijer fiber therapy — all for this same purpose.

Most products note that psyllium generally produces a bowel movement within 12 to 72 hours of taking a dose.

See full Psyllium drug information
Keep checking

Other Drugs & Apoaequorin

Browse every other medication we’ve checked against Apoaequorin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Apoaequorin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Apoaequorin list.

See the full Apoaequorin interactions page
See every supplement checked against Psyllium (OTC drug), ranked by severity
Evidence & sources

Apoaequorin References

The 1 references that drive our Apoaequorin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. GRAS Notice (GRN) No. 568. U.S. Food and Drug Administration Web site. Available at: http://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/UCM457034.pdf. Accessed September 28, 2015.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Apoaequorin and Psyllium (OTC drug) Together: Common Questions

Is it safe to take Apoaequorin with Psyllium (OTC drug)?
We do not list a known interaction between Apoaequorin and Psyllium (OTC drug). That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Psyllium (OTC drug) interact with any supplements?
Yes. Psyllium (OTC drug) has documented interactions with 17 supplements in our database — Apoaequorin is not one of them. The Psyllium (OTC drug) interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Apoaequorin monograph Uses, safety profile, and every drug interaction in one place Psyllium drug information The full plain-English guide to this medication Psyllium (OTC drug) supplement interactions Every supplement checked against Psyllium (OTC drug), ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Psyllium (OTC drug) and Apoaequorin?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.