Apple Polyphenols + Insulin (rDNA)
Insulin (rDNA) brand names: Humalog, Humalog Mix 75/25, Humulin R, Humulin N, Humulin L, and others.
Apple Polyphenols has a moderate interaction with Insulin (rDNA). In healthy adults, taking 900-1800 mg of a polyphenol-rich apple extract prior to a meal delays the time to peak postprandial blood glucose levels.
Read the full interaction reportApple Polyphenols and Insulin (rDNA)
Here is the interaction we found between these two, with the evidence behind it.
INSULIN
Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..
Here's the gist for someone using insulin like Humalog or Humulin. Concentrated apple polyphenol extracts (the studies used about 900 to 1,800 mg before a meal) seem to slow down how fast your blood sugar rises after eating. Since insulin is already lowering your sugar, stacking the two together could push your blood sugar a bit lower than you expect, especially around mealtimes.
That means watching for the usual signs of low blood sugar: shakiness, sweating, dizziness, a racing heart, confusion, or feeling suddenly hungry. The evidence here is fairly limited and the effect is considered moderate, so don't panic, but do check your blood sugar more closely if you start a supplement. Please loop in your pharmacist or doctor before changing anything, since your insulin timing or dose may need a tweak.
- Prpa EJ, Corpe CP, Atkinson B, et al. Apple polyphenol-rich drinks dose-dependently decrease early-phase postprandial glucose concentrations following a high-carbohydrate meal: a randomized controlled trial in healthy adults and in vitro studies. J Nutr B PubMed
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Apple Polyphenols Also Interacts With Other Medications
Apple Polyphenols has 12 moderate known drug interactions in our database — the Insulin (rDNA) one above is one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Apple Polyphenols
We haven’t checked that one against Apple Polyphenols yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Apple Polyphenols. Pick one to open its full report.
See Every Supplement That Interacts With Insulin (rDNA)
This page covers Apple Polyphenols only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Insulin (rDNA) page lists 242 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Chelation Therapy Products (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).
By severity: 2 major · 211 moderate · 29 minor.
From our pharmacist’s overview on the Insulin (rDNA) page
“A weed called Siberian cocklebur has caused severe low blood sugar in humans and is the one ingredient to avoid outright while using insulin (rDNA) products like Humalog or Humulin. This list deserves real respect.”
Reviewed by 2 · Jul 18, 2026
Where Apple Polyphenols and Insulin (rDNA) Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,194 of 1,452 supplements looked up here in the last 7 days
#859 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Apple Polyphenols
What is Apple Polyphenols?
- High cholesterol
- High blood pressure
- Weight management
- Antioxidant support
- Blood sugar support
- Skin health (topical)
Apple polyphenols are antioxidant plant compounds taken from apples and marketed for heart, weight, and blood sugar health. Early research is interesting, but there is not enough reliable human evidence to confirm these benefits. They appear generally safe in food-like amounts, but talk with your pharmacist or doctor before using concentrated supplements.
About Insulin Lispro Injection
What Is Insulin Lispro Injection Used For?
Brand names: Humalog, Humalog Mix 75/25, Humulin R, Humulin N, Humulin L, Humulin 50/50, Humulin 70/30, Humulin U, NovoLog, Velosulin, Novolog Mix 70/30, Actrapid, Humulin S, Insuman Rapid
Insulin lispro injection is used to improve glycemic control (blood sugar management) in people with diabetes mellitus. It is a rapid-acting insulin analog approved for use in both type 1 and type 2 diabetes.
Admelog is specifically indicated to improve glycemic control in patients with diabetes mellitus. Humalog Mix75/25 is indicated to improve glycemic control in adults with diabetes mellitus; it is a fixed-ratio mixture of insulin lispro and insulin lispro protamine, and its fixed proportions do not allow for separate adjustment of basal (background) and prandial (mealtime) doses.
Other Drugs & Apple Polyphenols
Browse every other medication we’ve checked against Apple Polyphenols — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
12 interactions
No interaction 2,817 drugs checked — show the list
We also checked Apple Polyphenols against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Sertraline ›
- Losartan Potassium ›
- Acetaminophen ›
- Aspirin ›
- Rosuvastatin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Warfarin Sodium ›
- Tirzepatide ›
- Ibuprofen ›
- Amlodipine Besylate ›
- Methamphetamine ›
- Docusate ›
- Tadalafil ›
- Hydroxyurea ›
- Metformin ›
- Valacyclovir ›
- Prednisone ›
- Sumatriptan ›
- Semaglutide ›
- Amitriptyline ›
- Lisdexamfetamine ›
- Amphetamine ›
- Levothyroxine, Liothyronine ›
- Methotrexate ›
- Propranolol ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Fluoxetine ›
- Azithromycin ›
- Bendamustine ›
- Pregabalin ›
- Doxycycline ›
- Gabapentin ›
- Dextroamphetamine ›
- Lamotrigine ›
- Acyclovir ›
- Naproxen ›
- Acetaminophen, Aspirin, Caffeine ›
- Quetiapine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Citalopram ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,817 medications checked with no known interaction — see the full Apple Polyphenols list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Insulin (rDNA) Is Linked to Lower Levels of 2 Nutrients
Natural Medicines records Insulin (rDNA) as a medicine that can lower these. This is not an interaction with Apple Polyphenols — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Insulin (rDNA) nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Apple Polyphenols and Insulin (rDNA) Together: Common Questions
Can you take Apple Polyphenols with Insulin (rDNA)?
How serious is the Apple Polyphenols and Insulin (rDNA) interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Still Have a Question About Insulin (rDNA) and Apple Polyphenols?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.