Apple Polyphenols + Tipiracil Hydrochloride, Trifluridine
Tipiracil Hydrochloride, Trifluridine brand name: Lonsurf.
We found no known interaction between Apple Polyphenols and Tipiracil Hydrochloride, Trifluridine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tipiracil Hydrochloride, Trifluridine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Apple Polyphenols and Tipiracil Hydrochloride, Trifluridine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Tipiracil Hydrochloride, Trifluridine and Apple Polyphenols in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Apple Polyphenols safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Tipiracil Hydrochloride, Trifluridine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Tipiracil Hydrochloride, Trifluridine is filed under a single classification — oral drugs. Apple Polyphenols has documented interactions with 1 drug class — the most serious being insulin (moderate) — and none of Tipiracil Hydrochloride, Trifluridine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Apple Polyphenols Does Interact With Other Medications
Apple Polyphenols has 13 moderate known drug interactions in our database — Tipiracil Hydrochloride, Trifluridine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Apple Polyphenols
We haven’t checked that one against Apple Polyphenols yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Apple Polyphenols. Pick one to open its full report.
Some Tipiracil Hydrochloride, Trifluridine Products Have a Food Rule — Apple Polyphenols Should Not Break It
At least one FDA label for a product containing Tipiracil Hydrochloride, Trifluridine says to take it with food. If you take Apple Polyphenols on an empty stomach out of habit, keep them separate — and take Tipiracil Hydrochloride, Trifluridine with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tipiracil Hydrochloride, Trifluridine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
2 DOSAGE AND ADMINISTRATION Recommended Dosage : 35 mg/m 2 /dose orally twice daily with food on Days 1 through 5 and Days 8 through 12 of each 28-day cycle.
From the Dosage and Administration section of the FDA label we read for Tipiracil Hydrochloride, Trifluridine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Tipiracil Hydrochloride, Trifluridine
This page covers Apple Polyphenols only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tipiracil Hydrochloride, Trifluridine page lists 17 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 9 minor.
Open the Tipiracil Hydrochloride, Trifluridine interaction page
Where Apple Polyphenols and Tipiracil Hydrochloride, Trifluridine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#997 of 1,452 supplements looked up here in the last 7 days
#432 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Apple Polyphenols reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Apple Polyphenols and Tipiracil Hydrochloride, Trifluridine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Apple Polyphenols
What is Apple Polyphenols?
- High cholesterol
- High blood pressure
- Weight management
- Antioxidant support
- Blood sugar support
- Skin health (topical)
Apple polyphenols are antioxidant plant compounds taken from apples and marketed for heart, weight, and blood sugar health. Early research is interesting, but there is not enough reliable human evidence to confirm these benefits. They appear generally safe in food-like amounts, but talk with your pharmacist or doctor before using concentrated supplements.
Malus domestica · Rosaceae · Fruit, peel, and pomace (sometimes unripe apples) · Capsules, tablets, powders, and standardized extracts
An interaction check asks whether these two react with each other — it does not ask whether Apple Polyphenols is a good idea for someone in your situation. Here is what our Apple Polyphenols record says about it on its own.
Apple Polyphenols: dosing
There is no standardized, well-established dose for apple polyphenols. Products vary widely in how much polyphenol they contain.The best approach is to follow the directions on the product label and not exceed the suggested amount.
From our Apple Polyphenols monograph — the full record covers uses, side effects and every documented interaction.
About Trifluridine and Tipiracil
What Is Trifluridine and Tipiracil Used For?
Brand name: Lonsurf
Lonsurf (trifluridine and tipiracil) is used to treat adults with metastatic colorectal cancer — either alone or combined with bevacizumab — after prior treatment with several other chemotherapy regimens and targeted therapies.
Lonsurf is also used for adults with metastatic gastric or gastroesophageal junction adenocarcinoma (cancer of the stomach or where the stomach meets the esophagus) who have already received at least two prior chemotherapy regimens.
Other Drugs & Apple Polyphenols
Browse every other medication we’ve checked against Apple Polyphenols — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
13 interactions
No interaction 2,816 drugs checked — show the list
We also checked Apple Polyphenols against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Warfarin ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Losartan Potassium ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Docusate ›
- Tadalafil ›
- Tirzepatide ›
- Methamphetamine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Valacyclovir ›
- Hydroxyurea ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Propranolol ›
- Amitriptyline ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Bendamustine ›
- Methotrexate ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Azithromycin ›
- Acyclovir ›
- Pregabalin ›
- Lamotrigine ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Levothyroxine, Liothyronine ›
- Clonazepam ›
- Quetiapine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Duloxetine ›
- Methylene Blue ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,816 medications checked with no known interaction — see the full Apple Polyphenols list.
Apple Polyphenols References
The 10 references that drive our Apple Polyphenols monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Akazome Y, Kametani N, Kanda T, et al. Evaluation of safety of excessive intake and efficacy of long-term intake of beverages containing apple polyphenols. J Oleo Sci. 2010;59(6):321-38. PubMed
- Auclair S, Chironi G, Milenkovic D, et al. The regular consumption of a polyphenol-rich apple does not influence endothelial function: a randomised double-blind trial in hypercholesterolemic adults. Eur J Clin Nutr. 2010;64(10):1158-65. PubMed
- Deley G, Guillemet D, Allaert FA, Babault N. An Acute Dose of Specific Grape and Apple Polyphenols Improves Endurance Performance: A Randomized, Crossover, Double-Blind versus Placebo Controlled Study. Nutrients. 2017;9(8). pii: E917. PubMed
- Kamimura A, Takahashi T, Watanabe Y. Investigation of topical application of procyanidin B-2 from apple to identify its potential use as a hair growing agent. Phytomedicine. 2000;7(6):529-36. PubMed
- Kishi K, Saito M, Saito T, et al. Clinical efficacy of apple polyphenol for treating cedar pollinosis. Biosci Biotechnol Biochem. 2005;69(4):829-32. PubMed
- Nagasako-Akazome Y, Kanda T, Ohtake Y, Shimasaki H, Kobayashi T. Apple polyphenols influence cholesterol metabolism in healthy subjects with relatively high body mass index. J Oleo Sci. 2007;56(8):417-28. PubMed
- Takahashi T, Kamimura A, Kagoura M, et al. Investigation of the topical application of procyanidin oligomers from apples to identify their potential use as a hair-growing agent. J Cosmet Dermatol. 2005;4(4):245-9. PubMed
- Tenore GC, Caruso D, Buonomo G, et al. A Healthy Balance of Plasma Cholesterol by a Novel Annurca Apple-Based Nutraceutical Formulation: Results of a Randomized Trial. J Med Food. 2017;20(3):288-300. PubMed
- Saarenhovi M, Salo P, Scheinin M, et al. The effect of an apple polyphenol extract rich in epicatechin and flavan-3-ol oligomers on brachial artery flow-mediated vasodilatory function in volunteers with elevated blood pressure. Nutr. J 2017;16(1):73. PubMed
- Prpa EJ, Corpe CP, Atkinson B, et al. Apple polyphenol-rich drinks dose-dependently decrease early-phase postprandial glucose concentrations following a high-carbohydrate meal: a randomized controlled trial in healthy adults and in vitro studies. J Nutr B PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Apple Polyphenols and Tipiracil Hydrochloride, Trifluridine Together: Common Questions
Is it safe to take Apple Polyphenols with Tipiracil Hydrochloride, Trifluridine?
Do Apple Polyphenols and Tipiracil Hydrochloride, Trifluridine have any of the same side effects?
Should I take Apple Polyphenols and Tipiracil Hydrochloride, Trifluridine at the same time of day?
How was the Apple Polyphenols and Tipiracil Hydrochloride, Trifluridine combination checked?
Does Apple Polyphenols interact with any other medications?
Does Tipiracil Hydrochloride, Trifluridine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.