Arum + Ingenol Mebutate
Ingenol Mebutate brand name: Picato.
We found no known interaction between Arum and Ingenol Mebutate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Arum and Ingenol Mebutate
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Ingenol Mebutate and Arum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Arum safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Ingenol Mebutate
Interactions in our licensed database are recorded against drug classes, not just single drug names. Ingenol Mebutate is filed under a single classification — topical drugs. Arum has documented interactions with 1 drug class — the most serious being iron (minor) — and none of Ingenol Mebutate’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Arum Does Interact With Other Medications
Arum has 1 minor known drug interaction in our database — Ingenol Mebutate isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Arum
We haven’t checked that one against Arum yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Arum. Pick one to open its full report.
Arum in Pregnancy & Breastfeeding
When used orally because of its toxicity; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Ingenol Mebutate
This page covers Arum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ingenol Mebutate page lists 3 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).
By severity: 2 moderate · 1 minor.
From our pharmacist’s overview on the Ingenol Mebutate page
“Ingenol mebutate (Picato) is a gel applied to the skin for actinic keratosis, the rough precancerous patches caused by sun damage, and it is deliberately harsh, producing redness, flaking, and stinging as part of how it works. The few supplement interactions on record are all skin-level ones.”
Reviewed by 2 · Jul 18, 2026
Where Arum and Ingenol Mebutate Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,174 of 1,452 supplements looked up here in the last 7 days
#1,435 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Arum reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Arum and Ingenol Mebutate records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Arum
What is Arum?
- Coughs and chest congestion
- Sore throat
- Promoting sweating (diaphoretic)
- Skin and wart remedies (topical folk use)
- Digestive complaints
Arum is a traditional European plant whose root has been used in folk medicine, but there is essentially no reliable human research to support any health benefit. The raw plant is toxic and irritating because of calcium oxalate crystals, so it should not be eaten or used casually. We do not recommend using Arum as a supplement, especially during pregnancy or breastfeeding.
Arum maculatum · Araceae · Root (tuber), and sometimes leaves · Dried root preparations, tinctures, and traditional folk remedies
An interaction check asks whether these two react with each other — it does not ask whether Arum is a good idea for someone in your situation. Here is what our Arum record says about it on its own.
Arum: dosing
There is no established or standardized safe dose for Arum. Because the plant is toxic and human research is lacking, no trustworthy dosing guidelines exist.We do not recommend taking Arum. If you encounter a product that contains it, do not use it without first checking with a pharmacist or doctor, and never prepare or eat the raw plant yourself.
From our Arum monograph — the full record covers uses, side effects and every documented interaction.
About Ingenol Mebutate Topical
What Is Ingenol Mebutate Topical Used For?
Brand name: Picato
-
Ingenol mebutate gel is used to treat actinic keratosis (flat, scaly growths on the skin caused by too much sun exposure). Ingenol mebutate is in a class of medications called cytotoxic agents. It works by killing fast-growing cells such as the abnormal cells associated with actinic keratoses.
Other Drugs & Arum
Browse every other medication we’ve checked against Arum — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1 interaction
No interaction 2,828 drugs checked — show the list
We also checked Arum against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Ivermectin ›
- Abemaciclib ›
- Testosterone ›
- Losartan Potassium ›
- Sertraline ›
- Rosuvastatin ›
- Acetaminophen ›
- Aspirin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Rivaroxaban ›
- Isotretinoin ›
- Tirzepatide ›
- Levothyroxine, Liothyronine ›
- Ibuprofen ›
- Warfarin Sodium ›
- Amlodipine Besylate ›
- Docusate ›
- Metformin ›
- Prednisone ›
- Amitriptyline ›
- Methamphetamine ›
- Tadalafil ›
- Lisdexamfetamine ›
- Semaglutide ›
- Amphetamine ›
- Hydroxyurea ›
- Valacyclovir ›
- Sumatriptan ›
- Propranolol ›
- Amoxicillin ›
- Lisinopril ›
- Methotrexate ›
- Bupropion ›
- Azithromycin ›
- Fluoxetine ›
- Doxycycline ›
- Acetaminophen, Aspirin, Caffeine ›
- Pregabalin ›
- Gabapentin ›
- Dextroamphetamine ›
- Lamotrigine ›
- Naproxen ›
- Quetiapine ›
- Bendamustine ›
- Clonazepam ›
- Acyclovir ›
- Buspirone ›
- Duloxetine ›
- Omeprazole ›
- Citalopram ›
- Letrozole ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Arum list.
Arum References
The 3 references that drive our Arum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Mrvos, R., Dean, B. S., and Krenzelok, E. P. Philodendron/dieffenbachia ingestions: are they a problem? J Toxicol Clin Toxicol 1991;29(4):485-491. PubMed
- Prakash Raju KNJ, Goel K, Anandhi D, Pandit VR, Surendar R, Sasikumar M. Wild tuber poisoning: Arum maculatum - A rare case report. Int J Crit Illn Inj Sci. 2018;8(2):111-114. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Arum and Ingenol Mebutate Together: Common Questions
Is it safe to take Arum with Ingenol Mebutate?
How was the Arum and Ingenol Mebutate combination checked?
Does Arum interact with any other medications?
Does Ingenol Mebutate interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Ingenol Mebutate and Arum?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.