Arum + Netupitant, Palonosetron (Oral)
Netupitant, Palonosetron (Oral) brand name: Akynzeo.
We found no known interaction between Arum and Netupitant, Palonosetron (Oral) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Arum and Netupitant, Palonosetron (Oral)
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Netupitant, Palonosetron (Oral) and Arum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Arum safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Netupitant, Palonosetron (Oral)
Interactions in our licensed database are recorded against drug classes, not just single drug names. Netupitant, Palonosetron (Oral) is filed under 5 classifications — including cytochrome p450 3a4 (cyp3a4) inhibitors, serotonergic drugs, serotonergic drugs. Arum has documented interactions with 1 drug class — the most serious being iron (minor) — and none of Netupitant, Palonosetron (Oral)’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Arum Does Interact With Other Medications
Arum has 1 minor known drug interaction in our database — Netupitant, Palonosetron (Oral) isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Arum
We haven’t checked that one against Arum yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Arum. Pick one to open its full report.
Arum in Pregnancy & Breastfeeding
When used orally because of its toxicity; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Netupitant, Palonosetron (Oral)
This page covers Arum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Netupitant, Palonosetron (Oral) page lists 158 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Grapefruit (major), Lithium (major), St. John's Wort (major) and 5-htp (moderate).
By severity: 4 major · 113 moderate · 41 minor.
From our pharmacist’s overview on the Netupitant, Palonosetron (Oral) page
“Getting Akynzeo (netupitant and palonosetron) to work is the difference between finishing a chemotherapy cycle comfortably and losing days to nausea, so this list warrants genuine care. Most of it involves a liver enzyme, CYP3A4, that clears netupitant.”
Reviewed by 2 · Jul 18, 2026
Where Arum and Netupitant, Palonosetron (Oral) Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#855 of 1,452 supplements looked up here in the last 7 days
#120 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Arum reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Arum and Netupitant, Palonosetron (Oral) records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Arum
What is Arum?
- Coughs and chest congestion
- Sore throat
- Promoting sweating (diaphoretic)
- Skin and wart remedies (topical folk use)
- Digestive complaints
Arum is a traditional European plant whose root has been used in folk medicine, but there is essentially no reliable human research to support any health benefit. The raw plant is toxic and irritating because of calcium oxalate crystals, so it should not be eaten or used casually. We do not recommend using Arum as a supplement, especially during pregnancy or breastfeeding.
Arum maculatum · Araceae · Root (tuber), and sometimes leaves · Dried root preparations, tinctures, and traditional folk remedies
An interaction check asks whether these two react with each other — it does not ask whether Arum is a good idea for someone in your situation. Here is what our Arum record says about it on its own.
Arum: dosing
There is no established or standardized safe dose for Arum. Because the plant is toxic and human research is lacking, no trustworthy dosing guidelines exist.We do not recommend taking Arum. If you encounter a product that contains it, do not use it without first checking with a pharmacist or doctor, and never prepare or eat the raw plant yourself.
From our Arum monograph — the full record covers uses, side effects and every documented interaction.
About Netupitant and Palonosetron
What Is Netupitant and Palonosetron Used For?
Brand name: Akynzeo
Akynzeo capsules are used in adults to prevent both the short-term (acute) and longer-lasting (delayed) nausea and vomiting that can follow cancer chemotherapy — including, but not limited to, highly emetogenic (strongly nausea-causing) chemotherapy regimens. It is always taken together with the steroid dexamethasone.
Akynzeo capsules cover a broad range of chemotherapy regimens, including anthracycline plus cyclophosphamide-based regimens. Each ingredient targets a different stage: palonosetron addresses nausea and vomiting in the first 24 hours, while netupitant covers both the early and the delayed phase that can last several days after treatment.
Other Drugs & Arum
Browse every other medication we’ve checked against Arum — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
1 interaction
No interaction 2,828 drugs checked — show the list
We also checked Arum against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Sertraline ›
- Acetaminophen ›
- Losartan Potassium ›
- Aspirin ›
- Rosuvastatin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Rivaroxaban ›
- Atorvastatin ›
- Isotretinoin ›
- Tirzepatide ›
- Warfarin Sodium ›
- Amlodipine Besylate ›
- Ibuprofen ›
- Methamphetamine ›
- Docusate ›
- Sumatriptan ›
- Tadalafil ›
- Valacyclovir ›
- Hydroxyurea ›
- Prednisone ›
- Metformin ›
- Amitriptyline ›
- Semaglutide ›
- Lisdexamfetamine ›
- Amphetamine ›
- Propranolol ›
- Amoxicillin ›
- Levothyroxine, Liothyronine ›
- Methotrexate ›
- Lisinopril ›
- Bupropion ›
- Fluoxetine ›
- Bendamustine ›
- Azithromycin ›
- Pregabalin ›
- Doxycycline ›
- Dextroamphetamine ›
- Gabapentin ›
- Lamotrigine ›
- Acyclovir ›
- Naproxen ›
- Quetiapine ›
- Acetaminophen, Aspirin, Caffeine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Duloxetine ›
- Letrozole ›
- Citalopram ›
- Acetaminophen, Codeine ›
Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Arum list.
Arum References
The 3 references that drive our Arum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Mrvos, R., Dean, B. S., and Krenzelok, E. P. Philodendron/dieffenbachia ingestions: are they a problem? J Toxicol Clin Toxicol 1991;29(4):485-491. PubMed
- Prakash Raju KNJ, Goel K, Anandhi D, Pandit VR, Surendar R, Sasikumar M. Wild tuber poisoning: Arum maculatum - A rare case report. Int J Crit Illn Inj Sci. 2018;8(2):111-114. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Arum and Netupitant, Palonosetron (Oral) Together: Common Questions
Is it safe to take Arum with Netupitant, Palonosetron (Oral)?
How was the Arum and Netupitant, Palonosetron (Oral) combination checked?
Does Arum interact with any other medications?
Does Netupitant, Palonosetron (Oral) interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.