Drug & supplement interaction

Aspen + Collagenase Clostridium Histolyticum-Aaes

Collagenase Clostridium Histolyticum-Aaes brand name: Qwo.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Oct 4, 2026

The bottom line No known interaction

We found no known interaction between Aspen and Collagenase Clostridium Histolyticum-Aaes in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Aspen and Collagenase Clostridium Histolyticum-Aaes

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Collagenase Clostridium Histolyticum-Aaes and Aspen in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Aspen safety at a glance

Aspen overall Use caution It contains aspirin-like salicylates and may cause similar side effects, so use carefully.

Pregnancy Avoid Because of its aspirin-like activity and lack of safety data, it is best avoided during pregnancy.

Breastfeeding Avoid Not enough is known about safety, and salicylates can pass into breast milk, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Collagenase Clostridium Histolyticum-Aaes and Aspen? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

Keep it in perspective

Aspen Does Interact With Other Medications

Aspen has 39 moderate known drug interactions in our database — Collagenase Clostridium Histolyticum-Aaes isn’t one of them. If you take anything else, check it against the full list below.

Moderate 39 No known interaction 2,791 (incl. Collagenase Clostridium Histolyticum-Aaes)

Taking anything else?

Check Another of Your Medications Against Aspen

Covers the 2,830 medications we’ve checked against Aspen. Pick one to open its full report.

What to actually watch for

What Aspen Itself Has Been Linked To

This is not an interaction — nothing below involves Collagenase Clostridium Histolyticum-Aaes. It is the side-effect record for Aspen on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Aspen, this list is the first place to look.

A skin rash Additional detail
“There is currently a limited amount of information available about the adverse effects of aspen. Aspen contains salicin, a plant salicylate. Theoretically, aspen taken orally may be associated with the adverse effects seen with other salicylates, such as aspirin. Topically, aspen has been associated with allergic dermatitis.”

Aspen · Natural Medicines adverse-effect record, reported in dermatitis.
2 sources cited

3700. Goodman LS, Gilman A. The Pharmacological Basis of Therapeutics. 5th ed. New York, NY: Macmillan Publ. Co., Inc., 1975.

101465. Aalto-Korte K, Välimaa J, Henriks-Eckerman ML, Jolanki R. Allergic contact dermatitis from salicyl alcohol and salicylaldehyde in aspen bark (Populus tremula). Contact Dermatitis 2005;52(2):93-5.
“A case report describes a 58-year-old man who developed allergic contact dermatitis after handling aspen leaves and bark. The rash spread from his hands to his face, trunk, and extremities. He had positive skin patch tests to salicyl alcohol and salicylaldehyde, which are present in aspen as glucosides, such as salicin.”

Aspen · Natural Medicines adverse-effect record, reported in dermatitis.
1 source cited

101465. Aalto-Korte K, Välimaa J, Henriks-Eckerman ML, Jolanki R. Allergic contact dermatitis from salicyl alcohol and salicylaldehyde in aspen bark (Populus tremula). Contact Dermatitis 2005;52(2):93-5.

Everything above comes from the Natural Medicines adverse-effect record for Aspen — expand a row for the licensed statement it rests on. We haven’t matched Collagenase Clostridium Histolyticum-Aaes to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Collagenase Clostridium Histolyticum-Aaes.

One more smart check

Taking Aspen as Part of a Dietary Supplement Product? Check It for Interactions

We hold 8 real supplement products containing Aspen, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Aspen. Even though Aspen itself has no known interaction with Collagenase Clostridium Histolyticum-Aaes, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Aspen and Collagenase Clostridium Histolyticum-Aaes Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Aspen

Steady interest

#870 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Collagenase Clostridium Histolyticum-Aaes

Top 5%

#136 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Aspen reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Aspen and Collagenase Clostridium Histolyticum-Aaes records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Aspen

What is Aspen?

Joint and muscle pain
Arthritis-related discomfort
Urinary tract symptoms and prostate issues
Mild fever and inflammation
Nerve pain (sciatica, neuropathic pain)

Aspen bark and leaf contain salicin, a natural compound related to aspirin, which is why it is traditionally used for pain, fever, and inflammation. Solid human studies are lacking, and because it acts like aspirin it carries similar risks. Talk to your pharmacist or doctor before using it, especially if you are sensitive to aspirin.

Populus tremuloides · Salicaceae · Bark and leaves (sometimes leaf buds) · Capsules, tinctures, liquid extracts, teas, and dried bark; often combined with other herbs

An interaction check asks whether these two react with each other — it does not ask whether Aspen is a good idea for someone in your situation. Here is what our Aspen record says about it on its own.

Aspen: dosing

There is no well-established, standardized dose for aspen. The amount of salicin in products can vary widely, and many products combine aspen with other herbs.The safest approach is to follow the directions on the specific product label and not exceed the recommended amount.

From our Aspen monograph — the full record covers uses, side effects and every documented interaction.

Read the full Aspen monograph & all interactions

Medication

About Collagenase Clostridium histolyticum Injection

What Is Collagenase Clostridium histolyticum Injection Used For?

Brand name: Qwo

Collagenase Clostridium histolyticum injection (Xiaflex) is used to treat Dupuytren's contracture (a painless thickening and tightening of tissue [cord] beneath the skin in the palm of the hand, which may make it difficult to straighten one or more fingers) when a cord of tissue can be felt upon examination. Collagenase Clostridium histolyticum injection (Xiaflex) is also used to treat Peyronie's disease (a thickening of tissue [plaque] inside the penis that causes the penis to curve). Collagenase Clostridium histolyticum injection (QWO) is also used to treat cellulite (fat deposit beneath the skin) in the buttocks of adult women. Collagenase Clostridium histolyticum injection is in a class of medications called enzymes. In people with Dupuytren's contracture, it works by helping to break down the cord of thickened tissue and allows the finger(s) to be straightened. In people with Peyronie's disease, it works by helping to break down the plaque of thickened tissue and allows the penis to be straightened. In women with cellulite, it works by releasing fibrous bands, redistributing fat cells, and stimulating the growth of new collagen.

See full Collagenase Clostridium histolyticum Injection drug information

Keep checking

Other Drugs & Aspen

Browse every other medication we’ve checked against Aspen — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

39Moderate

0Minor

2,790No known interaction

39 Moderate 2,790 No interaction

Moderate

39 interactions

No interaction 2,790 drugs checked — show the list

We also checked Aspen against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,790 medications checked with no known interaction — see the full Aspen list.

See the full Aspen interactions page

See every supplement checked against Collagenase Clostridium Histolyticum-Aaes, ranked by severity

Evidence & sources

Aspen References

The 3 references that drive our Aspen monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Goodman LS, Gilman A. The Pharmacological Basis of Therapeutics. 5th ed. New York, NY: Macmillan Publ. Co., Inc., 1975.
Aalto-Korte K, Välimaa J, Henriks-Eckerman ML, Jolanki R. Allergic contact dermatitis from salicyl alcohol and salicylaldehyde in aspen bark (Populus tremula). Contact Dermatitis 2005;52(2):93-5.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Aspen and Collagenase Clostridium Histolyticum-Aaes Together: Common Questions

Is it safe to take Aspen with Collagenase Clostridium Histolyticum-Aaes?

We do not list a known interaction between Aspen and Collagenase Clostridium Histolyticum-Aaes. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Does Aspen interact with any other medications?

Yes. Aspen has 39 documented drug interactions in our database — Collagenase Clostridium Histolyticum-Aaes is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Aspen monograph Uses, safety profile, and every drug interaction in one place Collagenase Clostridium histolyticum Injection drug information The full plain-English guide to this medication Collagenase Clostridium Histolyticum-Aaes supplement interactions Every supplement checked against Collagenase Clostridium Histolyticum-Aaes, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Collagenase Clostridium Histolyticum-Aaes and Aspen?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.