Drug & supplement interaction

Avocado + Glyburide, Metformin

Glyburide, Metformin brand name: Glucovance.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Avocado and Glyburide, Metformin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Glyburide, Metformin states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Avocado and Glyburide, Metformin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Glyburide, Metformin and Avocado in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Avocado safety at a glance

Avocado overall Generally safe Avocado is widely eaten and considered safe as a food for most people.
Pregnancy Use caution Avocado as a food is fine, but concentrated supplements or extracts have not been well studied in pregnancy.
Breastfeeding Use caution Eating avocado is generally fine, but the safety of concentrated supplements while breastfeeding is unknown.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Glyburide, Metformin and Avocado? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Glyburide, Metformin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Glyburide, Metformin is filed under 10 classifications — including sulfonylureas, organic cation transporter 2 (oct2) substrates, organic anion-transporting polypeptide substrates (oatp). Avocado has documented interactions with 1 drug class — the most serious being warfarin (coumadin) (moderate) — and none of Glyburide, Metformin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Avocado Does Interact With Other Medications

Avocado has 2 moderate known drug interactions in our database — Glyburide, Metformin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 2 No known interaction 2,828 (incl. Glyburide, Metformin)
Taking anything else?

Check Another of Your Medications Against Avocado

Covers the 2,830 medications we’ve checked against Avocado. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Avocado and Glyburide, Metformin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A higher chance of infection Worth acting on Additional detail

    Avocado

    “Orally, avocado can cause acute food protein-induced enterocolitis syndrome (FPIES). This is a rare, delayed, non-IgE-mediated gastrointestinal food hypersensitivity reaction most often reported in infants and young children. Symptoms of FPIES include excessive vomiting within 1-4 hours of avocado consumption and diarrhea.”

    Avocado · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 100938. Cherian S, Neupert K, Varshney P. Avocado as an emerging trigger for food protein-induced enterocolitis syndrome. Ann Allergy Asthma Immunol. 2018;121(3):369-71. PubMed
    2. 112436. Lichtenstein AH, Kris-Etherton PM, Petersen KS, et al. Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity: A Randomized Trial. J Am Heart Assoc 2022;11(14):e025657.

    Glyburide, Metformin

    Listed in the ADVERSE REACTIONS section of the FDA label for Glyburide, Metformin. Read the label on DailyMed ›

  • Diarrhea / Vomiting Additional detail

    Avocado

    “Orally, avocado has been generally well tolerated in clinical research.

    Most Common Adverse Effects:

    Topically: A cream containing avocado oil in combination with vitamin B12 can cause itching.

    Serious Adverse Effects (Rare):

    Orally: Avocado may lead to allergic cross-sensitivity in latex sensitive patients.”

    Avocado · Natural Medicines adverse-effect record, reported in diarrhea.

    Glyburide, Metformin

    Listed in the ADVERSE REACTIONS section of the FDA label for Glyburide, Metformin. Read the label on DailyMed ›

Reported for Avocado but not commonly for Glyburide, Metformin: an allergic reaction, stomach upset, a skin rash and bloating or gas.

Effects for Glyburide, Metformin come from the ADVERSE REACTIONS section of its FDA label; effects for Avocado come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Glyburide, Metformin Products Have a Food Rule — Avocado Should Not Break It

At least one FDA label for a product containing Glyburide, Metformin says to take it with food. If you take Avocado on an empty stomach out of habit, keep them separate — and take Glyburide, Metformin with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Glyburide, Metformin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

For patients with type 2 diabetes whose hyperglycemia cannot be satisfactorily managed with diet and exercise alone, the recommended starting dose is 1.25 mg glyburide and 250 mg metformin hydrochloride once a day with a meal.

From the Dosage and Administration section of the FDA label we read for Glyburide, Metformin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Glyburide, Metformin

This page covers Avocado only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glyburide, Metformin page lists 332 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Apple (major), Beer (major), Grapefruit (major) and Siberian Cocklebur (major).

By severity: 7 major · 281 moderate · 44 minor.

From our pharmacist’s overview on the Glyburide, Metformin page

“Glucovance combines glyburide and metformin to lower blood sugar, and its list of 332 interacting supplements deserves real care, starting with the seven rated major. Most entries, 239 of them, lower blood sugar on their own, so stacking one on top of a drug built to do exactly that can drop your glucose into dangerous territory.”

Reviewed by 2 · Jul 18, 2026

Open the Glyburide, Metformin interaction page

One more smart check

Taking Avocado as Part of a Dietary Supplement Product? Check It for Interactions

We hold 68 real supplement products containing Avocado, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Avocado. Even though Avocado itself has no known interaction with Glyburide, Metformin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Avocado and Glyburide, Metformin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Avocado
Top half

#533 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Glyburide, Metformin
Top half

#1,255 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Avocado reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Avocado and Glyburide, Metformin records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Avocado

What is Avocado?

Avocado
  • Heart and cholesterol health
  • Osteoarthritis (as ASU)
  • General nutrition and healthy fats
  • Skin and hair care
  • Blood sugar support

Avocado is a nutritious fruit rich in healthy monounsaturated fats, fiber, and potassium, and eating it as part of a balanced diet may support heart health. A specific extract called avocado/soybean unsaponifiables (ASU) has been studied for osteoarthritis, but evidence is mixed. As a food it is very safe for most people; talk to your pharmacist or doctor before using concentrated supplements.

Persea americana · Lauraceae · Fruit pulp, oil, seed, and leaves · Whole fruit, avocado oil, capsules (avocado/soybean unsaponifiables or ASU), powders

An interaction check asks whether these two react with each other — it does not ask whether Avocado is a good idea for someone in your situation. Here is what our Avocado record says about it on its own.

Avocado: dosing

There is no official standardized dose of avocado, since it is mainly eaten as a food. A common serving is part of a whole fruit, eaten as part of a balanced diet.For supplements such as ASU, the right amount depends on the specific product, so it is best to follow the directions on the label.

From our Avocado monograph — the full record covers uses, side effects and every documented interaction.

Read the full Avocado monograph & all interactions
Keep checking

Other Drugs & Avocado

Browse every other medication we’ve checked against Avocado — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
2Moderate
0Minor
2,827No known interaction
2 Moderate 2,827 No interaction
Moderate

2 interactions

No interaction 2,827 drugs checked — show the list

We also checked Avocado against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,827 medications checked with no known interaction — see the full Avocado list.

See the full Avocado interactions page
See every supplement checked against Glyburide, Metformin, ranked by severity
Evidence & sources

Avocado References

The 10 references that drive our Avocado monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blickstein D, Shaklai M, Inbal A. Warfarin antagonism by avocado. Lancet 1991;337:914-5. PubMed
  2. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
  3. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  4. Stucker M, Memmel U, Hoffmann M, et al. Vitamin B(12) cream containing avocado oil in the therapy of plaque psoriasis. Dermatology 2001;203:141-7.
  5. Ahlroth, M., Alenius, H., Turjanmaa, K., Makinen-Kiljunen, S., Reunala, T., and Palosuo, T. Cross-reacting allergens in natural rubber latex and avocado. J.Allergy Clin.Immunol. 1995;96(2):167-173. PubMed
  6. de Groot, A. C., van der Meeren, H. L., and Weyland, J. W. Contact allergy to avocado oil in a sunscreen. Contact Dermatitis 1987;16(2):108-109. PubMed
  7. Blanco, C., Carrillo, T., Castillo, R., Quiralte, J., and Cuevas, M. Avocado hypersensitivity. Allergy 1994;49(6):454-459. PubMed
  8. Crisi, G. and Belsito, D. V. Contact urticaria from latex in a patient with immediate hypersensitivity to banana, avocado and peach. Contact Dermatitis 1993;28(4):247-248.
  9. Cherian S, Neupert K, Varshney P. Avocado as an emerging trigger for food protein-induced enterocolitis syndrome. Ann Allergy Asthma Immunol. 2018;121(3):369-71. PubMed
  10. Lichtenstein AH, Kris-Etherton PM, Petersen KS, et al. Effect of Incorporating 1 Avocado Per Day Versus Habitual Diet on Visceral Adiposity: A Randomized Trial. J Am Heart Assoc 2022;11(14):e025657.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Avocado and Glyburide, Metformin Together: Common Questions

Is it safe to take Avocado with Glyburide, Metformin?
We do not list a known interaction between Avocado and Glyburide, Metformin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Avocado and Glyburide, Metformin have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Avocado and Glyburide, Metformin at the same time of day?
At least one FDA label for a product containing Glyburide, Metformin says to take it with food. If you take Avocado on an empty stomach out of habit, keep them separate and take Glyburide, Metformin with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Glyburide, Metformin products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Avocado and Glyburide, Metformin combination checked?
Interactions in our licensed database are recorded against drug classes. Glyburide, Metformin is filed under 10 classifications, and Avocado has documented interactions with 1 drug class — none of Glyburide, Metformin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Avocado interact with any other medications?
Yes. Avocado has 2 documented drug interactions in our database — Glyburide, Metformin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Glyburide, Metformin interact with any supplements?
Yes. Glyburide, Metformin has documented interactions with 332 supplements in our database — Avocado is not one of them. The Glyburide, Metformin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Avocado monograph Uses, safety profile, and every drug interaction in one place Glyburide, Metformin supplement interactions Every supplement checked against Glyburide, Metformin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Glyburide, Metformin and Avocado?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.