Drug & supplement interaction

Bee Venom + Phendimetrazine

Phendimetrazine brand names: Plegine, Metra, Weightrol.

No Known Interaction
Medically reviewed by · Updated October 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Bee Venom and Phendimetrazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Bee Venom and Phendimetrazine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Phendimetrazine and Bee Venom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bee Venom safety at a glance

Bee Venom overall Use caution Bee venom can trigger severe, even life-threatening allergic reactions and should be used only under professional supervision.
Pregnancy Avoid There is not enough safety information, and the risk of allergic reactions makes it best to avoid during pregnancy.
Breastfeeding Avoid Safety during breastfeeding is unknown, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Phendimetrazine and Bee Venom? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Phendimetrazine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Phendimetrazine is filed under a single classification — oral drugs. Bee Venom has documented interactions with 1 drug class — the most serious being immunosuppressants (moderate) — and none of Phendimetrazine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bee Venom Does Interact With Other Medications

Bee Venom has 121 moderate known drug interactions in our database — Phendimetrazine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 121 No known interaction 2,709 (incl. Phendimetrazine)
Taking anything else?

Check Another of Your Medications Against Bee Venom

Covers the 2,830 medications we’ve checked against Bee Venom. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Bee Venom and Phendimetrazine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A fast or pounding heartbeat Additional detail

    Bee Venom

    “Case reports have described stroke, and bradycardia associated with bee venom therapy. Other reported adverse cardiovascular effects include cardiac dysfunction, palpitations, hypotension, and chest pain or tightness.”

    Bee Venom · Natural Medicines adverse-effect record, reported in hypotension.

    6 sources cited
    1. 96576. Park JH, Yim BK, Lee JH, Lee S, Kim TH. Risk associated with bee venom therapy: a systematic review and meta-analysis. PLoS One. 2015;10(5):e0126971. PubMed
    2. 1343. Mosbech H, Muller U. Side-effects of insect venom immunotherapy: results from an EAACI multicenter study. Allergy 2000;55:1005-10. DOI
    3. 2619. Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
    4. 6070. Birnbaum J, Charpin D, Vervloet D. Rapid hymenoptera venom immunotherapy: comparative safety of three protocols. Clin Exp Allergy 1993;23:226-30. PubMed
    5. 6078. Ewan PW. ABC of allergies. Venom allergy. BMJ 1998;316:1365-8.
    6. 111472. Kim K, Jeong H, Lee G, Jang S, Yook T. Characteristics of Adverse Events in Bee Venom Therapy Reported in South Korea: A Survey Study. Toxins (Basel) 2021;14(1):18. PubMed

    Phendimetrazine

    Listed in the ADVERSE REACTIONS section of the FDA label for Phendimetrazine. Read the label on DailyMed ›

  • Dizziness / Nausea Additional detail

    Bee Venom

    Recorded for Bee Venom in the same Natural Medicines adverse-effect record shown under A fast or pounding heartbeat above.

    Phendimetrazine

    Listed in the ADVERSE REACTIONS section of the FDA label for Phendimetrazine. Read the label on DailyMed ›

  • Headache Additional detail

    Bee Venom

    “Bee venom can cause pain, headache, somnolence, and confusion. It has also been associated with a case of neuralgic amyotrophy.”

    Bee Venom · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 96576. Park JH, Yim BK, Lee JH, Lee S, Kim TH. Risk associated with bee venom therapy: a systematic review and meta-analysis. PLoS One. 2015;10(5):e0126971. PubMed

    Phendimetrazine

    Listed in the ADVERSE REACTIONS section of the FDA label for Phendimetrazine. Read the label on DailyMed ›

Reported for Bee Venom but not commonly for Phendimetrazine: shortness of breath, kidney problems, a low platelet count and an allergic reaction.

Effects for Phendimetrazine come from the ADVERSE REACTIONS section of its FDA label; effects for Bee Venom come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Phendimetrazine

This page covers Bee Venom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Phendimetrazine page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Phendimetrazine page

“Of the 17 supplements on file for phendimetrazine, an appetite-suppressant stimulant prescribed short term for weight loss, activated charcoal is the one that demands real caution. Charcoal binds medications in the gut and can sharply cut how much of a drug your body absorbs, leaving you with less appetite control than your prescriptio…”

Reviewed by 2 · Jul 18, 2026

Open the Phendimetrazine interaction page

One more smart check

Taking Bee Venom as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Bee Venom, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bee Venom. Even though Bee Venom itself has no known interaction with Phendimetrazine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bee Venom and Phendimetrazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bee Venom
Top half

#689 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Phendimetrazine
Top half

#1,187 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bee Venom reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Bee Venom and Phendimetrazine records this page draws on were last updated October 6, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bee Venom

What is Bee Venom?

Bee Venom
  • Joint pain and arthritis
  • Muscle and nerve pain
  • Bee sting allergy desensitization
  • Skin and cosmetic uses
  • Multiple sclerosis (traditional/alternative use)

Bee venom is a complex mixture of proteins and other compounds taken from honeybees and used in traditional medicine for pain and inflammation, and in conventional medicine for allergy shots to prevent severe sting reactions. Outside of supervised allergy treatment, strong evidence for its benefits is lacking, and it can cause serious allergic reactions, so it should only be used under medical supervision.

Venom secreted by the venom gland of the honeybee (Apis mellifera) · Purified injectable venom, bee sting therapy (live bees), creams and ointments, allergy desensitization extracts, some cosmetic products

An interaction check asks whether these two react with each other — it does not ask whether Bee Venom is a good idea for someone in your situation. Here is what our Bee Venom record says about it on its own.

Bee Venom: dosing

There is no standard, well-established dose of bee venom for general use. When it is used for allergy desensitization, an allergy specialist carefully chooses and adjusts the dose in a controlled setting.For over-the-counter creams or other products, follow the directions on the label. Do not try to treat yourself with live bee stings or injectable venom on your own.

From our Bee Venom monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bee Venom monograph & all interactions
Medication

About Phendimetrazine

What Is Phendimetrazine Used For?

Brand names: Plegine, Metra, Weightrol

Phendimetrazine is used short-term — typically a few weeks — to help manage obesity in adults who have a body mass index (BMI) of 30 or higher, or 27 or higher when other risk factors like high blood pressure, diabetes, or high cholesterol are present, and who have not lost enough weight through diet and exercise alone.

Phendimetrazine Tartrate extended-release capsules are specifically indicated for adults meeting those BMI criteria, including those with certain risk factors. Phendimetrazine Tartrate tablets are indicated for adults with a BMI of 30 or higher. Both forms are approved for use as a single medication only — not in combination with other weight-loss drugs or stimulants.

See full Phendimetrazine drug information
Keep checking

Other Drugs & Bee Venom

Browse every other medication we’ve checked against Bee Venom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
121Moderate
0Minor
2,708No known interaction
121 Moderate 2,708 No interaction
Moderate

121 interactions

Showing 60 of 121 moderate interactions — see all 121 on the Bee Venom page.

No interaction 2,708 drugs checked — show the list

We also checked Bee Venom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,708 medications checked with no known interaction — see the full Bee Venom list.

See the full Bee Venom interactions page
See every supplement checked against Phendimetrazine, ranked by severity
Evidence & sources

Bee Venom References

The 25 references that drive our Bee Venom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Mosbech H, Muller U. Side-effects of insect venom immunotherapy: results from an EAACI multicenter study. Allergy 2000;55:1005-10. DOI
  2. Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
  3. de Jong NW, Vermeulen AM, de Groot H. Allergy to bumblebee venom. III. Immunotherapy follow-up study (safety and efficacy) in patients with occupational bumblebee-venom anaphylaxis. Allergy 1999;54:980-4. PubMed
  4. Cuende E, Fraguas J, Pena JE, et al. Beekeepers' arthropathy. J Rheumatol 1999;26:2684-90.
  5. Petroianu G, Liu J, Helfrich U, et al. Phosholipase A2-induced coagulation abnormalities after bee sting. Am J Emerg Med 2000;18:22-7.
  6. Birnbaum J, Charpin D, Vervloet D. Rapid hymenoptera venom immunotherapy: comparative safety of three protocols. Clin Exp Allergy 1993;23:226-30. PubMed
  7. Bomalaski JS, Ford T, Hudson AP, Clark MA. Phospholipase A2-activating protein induces the synthesis of IL-1 and TNF in human monocytes. J Immunol 1995;154:4027-31. DOI
  8. Li JT, Yunginger JW. Management of insect sting hypersensitivity. Mayo Clin Proc 1992;67:188-94. PubMed
  9. Golden DB, Kagey-Sobotka A, Lichtenstein LM. Survey of patients after discontinuing venom immunotherapy. J Allergy Clin Immunol 2000;105(2 Pt 1):385-90. PubMed
  10. Bousquet J, Muller UR, Dreboro S, et al. Immunotherapy with hymenoptera venoms. Allergy 1987;42:401-13. DOI
  11. Ewan PW. ABC of allergies. Venom allergy. BMJ 1998;316:1365-8.
  12. Alford C, Cox H, Wescott R. The effects of red bull energy drink on human performance and mood. Amino Acids 2001;21:139-50. PubMed
  13. Horwitz RI, Daniels SR. Bias or biology: evaluating the epidemiologic studies of L-tryptophan and the eosinophilia-myalgia syndrome. J Rheumatol Suppl 1996;46:60-72.
  14. Wesselius T, Heersema DJ, Mostert JP, et al. A randomized crossover study of bee sting therapy for multiple sclerosis. Neurology 2005;65:1764-8. PubMed
  15. Koh PS, Seo BK, Cho NS, Park HS, Park DS, Baek YH. Clinical effectiveness of bee venom acupuncture and physiotherapy in the treatment of adhesive capsulitis: a randomized controlled trial. J Shoulder Elbow Surg. 2013;22(8):1053-62. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bee Venom and Phendimetrazine Together: Common Questions

Is it safe to take Bee Venom with Phendimetrazine?
We do not list a known interaction between Bee Venom and Phendimetrazine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Bee Venom and Phendimetrazine have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Bee Venom and Phendimetrazine combination checked?
Interactions in our licensed database are recorded against drug classes. Phendimetrazine is filed under 1 classification, and Bee Venom has documented interactions with 1 drug class — none of Phendimetrazine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Bee Venom interact with any other medications?
Yes. Bee Venom has 121 documented drug interactions in our database — Phendimetrazine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Phendimetrazine interact with any supplements?
Yes. Phendimetrazine has documented interactions with 17 supplements in our database — Bee Venom is not one of them. The Phendimetrazine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bee Venom monograph Uses, safety profile, and every drug interaction in one place Phendimetrazine drug information The full plain-English guide to this medication Phendimetrazine supplement interactions Every supplement checked against Phendimetrazine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 25 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Phendimetrazine and Bee Venom?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.