Drug & supplement interaction

Beta-alanine + Diethylpropion

Diethylpropion brand names: Radtue, Tenuate, Durad, Tenuate Dosepan.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Beta-alanine and Diethylpropion in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Beta-alanine and Diethylpropion

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diethylpropion and Beta-alanine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Beta-alanine at all — not against Diethylpropion, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Beta-alanine safety at a glance

Beta-alanine overall Use caution Generally well tolerated in healthy adults, but it commonly causes harmless skin tingling and is not studied for long-term high doses.
Pregnancy Avoid There is not enough safety information, so it is best to avoid during pregnancy.
Breastfeeding Avoid There is not enough safety information, so it is best to avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diethylpropion and Beta-alanine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Beta-alanine Itself Has Been Linked To

This is not an interaction — nothing below involves Diethylpropion. It is the side-effect record for Beta-alanine on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Beta-alanine, this list is the first place to look.

  • Flushing / Numbness or tingling Additional detail

    “Orally, beta-alanine can cause a dose-dependent feeling of pins and needles (paresthesias) along with skin flushing. This generally starts on the scalp within 20 minutes of the dose, spreading to most of the body, and lasting for about an hour. This was described as severe at a dose of 40 mg/kg, tolerable at a dose of 20 mg/kg, and very mild at a dose of 10 mg/kg.”

    Beta-alanine · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    6 sources cited
    1. 16438. Harris RC, Tallon MJ, Dunnett M, et al. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids 2006;30:279-89.
    2. 94333. Bellinger PM, Minahan CL. The effect of ß-alanine supplementation on cycling time trials of different length. Eur J Sport Sci 2016;16(7):829-36.
    3. 94335. Chung W, Shaw G, Anderson ME, et al. Effect of 10 week beta-alanine supplementation on competition and training performance in elite swimmers. Nutrients 2012;4(10):1441-53. PubMed
    4. 94338. Glenn JM, Gray M, Stewart R, et al. Incremental effects of 28 days of beta-alanine supplementation on high-intensity cycling performance and blood lactate in masters female cyclists. Amino Acids 2015;47(12):2593-600. PubMed
    5. 94341. Gross M, Bieri K, Hoppeler H, Norman B, Vogt M. Beta-alanine supplementation improves jumping power and affects severe-intensity performance in professional alpine skiers. Int J Sport Nutr Exerc Metab 2014;24(6):665-73. PubMed
    6. 94342. Howe ST, Bellinger PM, Driller MW, Shing CM, Fell JW. The effect of beta-alanine supplementation on isokinetic force and cycling performance in highly trained cyclists. Int J Sport Nutr Exerc Metab 2013;23(6):562-70. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Beta-alanine — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Diethylpropion’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Diethylpropion column appears here.

Overlapping uses

What Diethylpropion Is Prescribed For, and What Beta-alanine Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Diethylpropion is a prescription medicine with approved uses on its FDA label. Beta-alanine is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Diethylpropion is prescribed for: Diethylpropion is used to help manage exogenous obesity (excess body weight from outside factors like diet) in adults with a body mass index (BMI) of 30 or higher who haven't lost enough weight through diet and exercise alone. It is meant to be used for only a few weeks as part of a calorie-restricted diet plan. All available tablet products — both the immediate-release tablets and the extended-release tablets — are approved for this purpose. Each is approved for use as a single medication only; combining diethylpropion with any other weight-loss drug is not allowed.

Beta-alanine has been studied for:

  • Obesity studied, not established Beta-alanine has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Beta-alanine for obesity

    It is unclear if oral beta-alanine improves body composition in adults.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Diethylpropion on your own; if you are taking Beta-alanine for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Diethylpropion

This page covers Beta-alanine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diethylpropion page lists 61 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Peyote (major), Rauvolfia Vomitoria (major) and Sida Cordifolia (major).

By severity: 5 major · 43 moderate · 13 minor.

From our pharmacist’s overview on the Diethylpropion page

“Diethylpropion (Tenuate) is an appetite suppressant that works by revving up the nervous system, and that mechanism is why its interaction list calls for real vigilance. Of the 61 supplements and herbs on file, 44 add their own stimulant push, raising the risk of high blood pressure, a pounding heart, and sleeplessness.”

Reviewed by 2 · Jul 18, 2026

Open the Diethylpropion interaction page

One more smart check

Taking Beta-alanine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3,759 real supplement products containing Beta-alanine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Beta-alanine. Even though Beta-alanine itself has no known interaction with Diethylpropion, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Beta-alanine and Diethylpropion Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Beta-alanine
Top 5%

#47 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diethylpropion
Steady interest

#2,488 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Beta-alanine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Beta-alanine and Diethylpropion records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Beta-alanine

What is Beta-alanine?

  • Athletic performance and endurance
  • High-intensity exercise capacity
  • Reducing muscle fatigue
  • Building muscle carnosine levels

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderate for performance in certain activities, but harmless tingling of the skin is common, and it is not well studied for pregnancy or any medical condition.

Non-essential amino acid (made in the body and found in meat, poultry, and fish) · Capsules, tablets, powder, pre-workout blends, sustained-release tablets

An interaction check asks whether these two react with each other — it does not ask whether Beta-alanine is a good idea for someone in your situation. Here is what our Beta-alanine record says about it on its own.

Beta-alanine: dosing

There is no official medical dose for beta-alanine, and the right amount depends on the product and your goals. Many supplements come as powders or capsules, sometimes as sustained-release tablets meant to reduce tingling.Beta-alanine usually needs to be taken consistently for several weeks before muscle carnosine builds up enough to matter — a single dose before a workout does not provide much benefit.

From our Beta-alanine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Beta-alanine monograph & all interactions
Medication

About Diethylpropion

What Is Diethylpropion Used For?

Brand names: Radtue, Tenuate, Durad, Tenuate Dosepan

Diethylpropion is used to help manage exogenous obesity (excess body weight from outside factors like diet) in adults with a body mass index (BMI) of 30 or higher who haven't lost enough weight through diet and exercise alone. It is meant to be used for only a few weeks as part of a calorie-restricted diet plan.

All available tablet products — both the immediate-release tablets and the extended-release tablets — are approved for this purpose. Each is approved for use as a single medication only; combining diethylpropion with any other weight-loss drug is not allowed.

See full Diethylpropion drug information
Keep checking

Other Drugs & Beta-alanine

Browse every other medication we’ve checked against Beta-alanine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
No interaction 2,829 drugs checked — show the list
Evidence & sources

Beta-alanine References

The 13 references that drive our Beta-alanine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Harris RC, Tallon MJ, Dunnett M, et al. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids 2006;30:279-89.
  2. Hill CA, Harris RC, Kim HJ, et al. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids 2007;32:225-33.
  3. Bellinger PM, Minahan CL. The effect of ß-alanine supplementation on cycling time trials of different length. Eur J Sport Sci 2016;16(7):829-36.
  4. Chung W, Shaw G, Anderson ME, et al. Effect of 10 week beta-alanine supplementation on competition and training performance in elite swimmers. Nutrients 2012;4(10):1441-53. PubMed
  5. Glenn JM, Gray M, Stewart R, et al. Incremental effects of 28 days of beta-alanine supplementation on high-intensity cycling performance and blood lactate in masters female cyclists. Amino Acids 2015;47(12):2593-600. PubMed
  6. Gross M, Bieri K, Hoppeler H, Norman B, Vogt M. Beta-alanine supplementation improves jumping power and affects severe-intensity performance in professional alpine skiers. Int J Sport Nutr Exerc Metab 2014;24(6):665-73. PubMed
  7. Howe ST, Bellinger PM, Driller MW, Shing CM, Fell JW. The effect of beta-alanine supplementation on isokinetic force and cycling performance in highly trained cyclists. Int J Sport Nutr Exerc Metab 2013;23(6):562-70. PubMed
  8. Sweeney KM, Wright GA, Glenn Brice A, Doberstein ST. The effect of beta-alanine supplementation on power performance during repeated sprint activity. J Strength Cond Res 2010;24(1):79-87.
  9. Décombaz J, Beaumont M, Vuichoud J, Bouisset F, Stellingwerff T. Effect of slow-release ß-alanine tablets on absorption kinetics and paresthesia. Amino Acids 2012;43(1):67-76. Erratum in: Amino Acids 2013;45(4):1015.
  10. Stellingwerff T, Anwander H, Egger A, et al. Effect of two ß-alanine dosing protocols on muscle carnosine synthesis and washout. Amino Acids 2012;42(6):2461-72. PubMed
  11. da Silva RP, de Oliveira LF, Saunders B, et al. Effects of ß-alanine and sodium bicarbonate supplementation on the estimated energy system contribution during high-intensity intermittent exercise. Amino Acids. 2019;51(1):83-96. PubMed
  12. Varanoske AN, Hoffman JR, Church DD, et al. Comparison of sustained-release and rapid-release ß-alanine formulations on changes in skeletal muscle carnosine and histidine content and isometric performance following a muscle-damaging protocol. Amino Acids. PubMed
  13. Perim P, Gobbi N, Duarte B, et al. Beta-alanine did not improve high-intensity performance throughout simulated road cycling. Eur J Sport Sci 2021. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Beta-alanine and Diethylpropion Together: Common Questions

Is it safe to take Beta-alanine with Diethylpropion?
We do not list a known interaction between Beta-alanine and Diethylpropion. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Are Beta-alanine and Diethylpropion used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Beta-alanine in each. That is a conversation for your prescriber, especially if Diethylpropion is being adjusted to a target.
Does Diethylpropion interact with any supplements?
Yes. Diethylpropion has documented interactions with 61 supplements in our database — Beta-alanine is not one of them. The Diethylpropion interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Diethylpropion and Beta-alanine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.