Medication interaction hub

What Supplements Interact with Diethylpropion?

Diethylpropion brand names: Radtue, Tenuate, Durad, Tenuate Dosepan. Every interaction below applies to the brands too.

61 Interactions 5 Major 43 Moderate 13 Minor
Curated & coded by · Clinical Pharmacist · Updated September 21, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Diethylpropion? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Diethylpropion against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Diethylpropion (Tenuate) is an appetite suppressant that works by revving up the nervous system, and that mechanism is why its interaction list calls for real vigilance. Of the 61 supplements and herbs on file, 44 add their own stimulant push, raising the risk of high blood pressure, a pounding heart, and sleeplessness. Ephedra leads the five rated major and belongs nowhere near this drug.

Caffeine is the everyday face of the same problem, whether from coffee, tea, or a weight-loss capsule, and it drives much of the 43-entry moderate column (another 13 rate minor). A separate group of 17 ingredients changes how much of an oral dose absorbs; activated charcoal, another major, can soak up the medication before it reaches the bloodstream, so those need generous spacing from the pill. This page deserves a careful read with your pharmacist rather than a quick skim.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 43 Minor 13 No known interaction 1,391

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Diethylpropion: Top Interactions at a Glance

The Diethylpropion supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 61 interacting ingredients — plus 1,391 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Diethylpropion Combinations Today

The Diethylpropion + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Octopamine + Diethylpropioni

Octopamine is thought to have stimulant effects.

Read the full interaction Moderate Likelihood Probable Caffeine + Diethylpropioni

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Moderate Likelihood Possible Bitter Orange + Diethylpropioni

Theoretically, bitter orange might increase the risk of hypertension and adverse cardiovascular effects when taken with stimulant drugs.

Read the full interaction Moderate Likelihood Possible Guarana + Diethylpropioni

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Minor Likelihood Possible Blond Psyllium + Diethylpropioni

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full interaction Major Likelihood Probable Activated Charcoal + Diethylpropioni

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction
The complete list

Every Supplement Checked Against Diethylpropion

All 1,452 ingredients in our database, ranked by severity — 61 with a Diethylpropion interaction on file and 1,391 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Diethylpropion?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Octopamine with Diethylpropion?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Octopamine is thought to have stimulant effects.

Full Octopamine + Diethylpropion answer

Can you take Caffeine with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Caffeine + Diethylpropion answer

Can you take Bitter Orange with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter orange might increase the risk of hypertension and adverse cardiovascular effects when taken with stimulant drugs.

Full Bitter Orange + Diethylpropion answer

Can you take Guarana with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Guarana + Diethylpropion answer

Can you take Blond Psyllium with Diethylpropion?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Diethylpropion answer

Can you take Adrafinil with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking adrafinil with stimulant drugs might have additive stimulant effects.

Full Adrafinil + Diethylpropion answer

Can you take Beta-methylphenethylamine (bmpea) with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking BMPEA with other stimulant drugs might increase the risk of adverse cardiovascular effects.

Full Beta-methylphenethylamine (bmpea) + Diethylpropion answer

Can you take Dimethylhexylamine (dmha) with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining DMHA with stimulant drugs might increase the risk of adverse cardiovascular effects.

Full Dimethylhexylamine (dmha) + Diethylpropion answer

Can you take Ergot with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Co-administration of stimulant drugs with ergot may increase the risk of vasoconstriction.

Full Ergot + Diethylpropion answer

Can you take Guar Gum with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Diethylpropion answer

Can you take Gum Arabic with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Diethylpropion answer

Can you take Higenamine with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the risk of cardiovascular toxicity when taken with stimulant drugs.

Full Higenamine + Diethylpropion answer

Can you take Hordenine with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hordenine is structurally similar to N-methyltyramine and synephrine, constituents in bitter orange known to have stimulant properties.

Full Hordenine + Diethylpropion answer

Can you take Indian Snakeroot with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might cause additive effects.

Full Indian Snakeroot + Diethylpropion answer

Can you take Isopropylnorsynephrine with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking isopropylnorsynephrine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascula...

Full Isopropylnorsynephrine + Diethylpropion answer

Can you take Khat with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cathinone, a constituent of khat, appears to have sympathomimetic effects and can increase blood pressure and heart rate.

Full Khat + Diethylpropion answer

Can you take Methylsynephrine with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Methylsynephrine has cardiac stimulant effects.

Full Methylsynephrine + Diethylpropion answer

Can you take Panax Ginseng with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Panax ginseng with stimulant drugs might increase the risk of adverse stimulant effects.

Full Panax Ginseng + Diethylpropion answer

Can you take Phenpromethamine with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking phenpromethamine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascular effe...

Full Phenpromethamine + Diethylpropion answer

Can you take Raspberry Ketone with Diethylpropion?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.

Full Raspberry Ketone + Diethylpropion answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Diethylpropion is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Diethylpropion, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Diethylpropion sits in 2 interaction categories. Open any one to see what the group means:

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Diethylpropion through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Diethylpropion through this category.

About Diethylpropion

Diethylpropion is a prescription appetite-suppressant used short-term, alongside diet, to help adults with obesity lose weight.

Generic name: Diethylpropion  ·  Brand names: Radtue, Tenuate, Durad, Tenuate Dosepan.

See the full Diethylpropion drug information
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Take a Supplement Product? Check the Whole Bottle Against Diethylpropion

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Diethylpropion.

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Pharmacist Counseling Corner

Diethylpropion & Supplements: Common Questions

What supplements interact with Diethylpropion?
Our database currently documents 61 ingredients with a known Diethylpropion interaction (5 major, 43 moderate, 13 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 61. The highest-ranked right now: Activated Charcoal, Ephedra, Peyote.
Which Diethylpropion supplement interactions are the most serious?
The 5 major-rated combinations — led by Activated Charcoal, Ephedra, Peyote, Rauvolfia Vomitoria and Sida Cordifolia — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Diethylpropion?
Plenty of supplements coexist fine with Diethylpropion; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Radtue have the same supplement interactions as Diethylpropion?
Yes — Radtue, Tenuate, Durad, Tenuate Dosepan all contain Diethylpropion, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Diethylpropion and my other medications?
This page covers Diethylpropion against supplements and herbal ingredients. Checking Diethylpropion against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Diethylpropion drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 21, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.