Drug & supplement interaction

Coconut + Diethylpropion

Diethylpropion brand names: Radtue, Tenuate, Durad, Tenuate Dosepan.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Coconut and Diethylpropion in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Coconut and Diethylpropion

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diethylpropion and Coconut in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Coconut safety at a glance

Coconut overall Generally safe Coconut is generally safe when eaten in normal food amounts.
Pregnancy Likely Safe When used orally in food amounts. There is insufficient reliable information available about the safety of coconut when used in medicinal amounts during pregnan... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in food amounts. There is insufficient reliable information available about the safety of coconut when used in medicinal amounts during pregnan... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diethylpropion and Coconut? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Diethylpropion

Interactions in our licensed database are recorded against drug classes, not just single drug names. Diethylpropion is filed under 2 classifications — stimulant drugs, oral drugs. Coconut has documented interactions with 1 drug class — the most serious being antidiabetes drugs (minor) — and none of Diethylpropion’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Coconut Does Interact With Other Medications

Coconut has 86 minor known drug interactions in our database — Diethylpropion isn’t one of them. If you take anything else, check it against the full list below.

Minor 86 No known interaction 2,744 (incl. Diethylpropion)
Taking anything else?

Check Another of Your Medications Against Coconut

Covers the 2,830 medications we’ve checked against Coconut. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Coconut and Diethylpropion May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Shortness of breath Worth acting on Additional detail

    Coconut

    “Although coconut is a stone fruit, in the US, coconut is grouped with tree nuts for allergen declaration purposes. Orally or topically, coconut can cause allergic reactions ranging from hives to anaphylaxis in those with hypersensitivity to coconut or its pollen.”

    Coconut · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    6 sources cited
    1. 107673. Kruse L, Lor J, Yousif R, Pongracic JA, Fishbein AB. Coconut allergy: Characteristics of reactions and diagnostic predictors in a pediatric tertiary care center. Ann Allergy Asthma Immunol 2021;126(5):562-568.
    2. 12359. Teuber SS, Peterson WR. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Cl PubMed
    3. 26561. Rosado A, Fernandez-Rivas M, Gonzalez-Mancebo E, et al. Anaphylaxis to coconut. Allergy 2002;57(2):182-3. PubMed
    4. 95806. Anagnostou K. Coconut Allergy Revisited. Children (Basel). 2017;4(10). pii: E85. PubMed
    5. 95807. Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015;115(6):530-2. PubMed
    6. 95808. Michavila Gomez A, Amat Bou M, Gonzalez Cortés MV, Segura Navas L, Moreno Palanques MA, Bartolomé B. Coconut anaphylaxis: Case report and review. Allergol Immunopathol (Madr). 2015;43(2):219-20. PubMed

    Diethylpropion

    Listed in the ADVERSE REACTIONS section of the FDA label for Diethylpropion. Read the label on DailyMed ›

  • Hives Worth acting on Additional detail

    Coconut

    “Orally, coconut is generally well tolerated.

    Most Common Adverse Effects:

    Orally and topically: Allergic reactions, including anaphylaxis and hives.”

    Coconut · Natural Medicines adverse-effect record, reported in urticaria.

    Diethylpropion

    Listed in the ADVERSE REACTIONS section of the FDA label for Diethylpropion. Read the label on DailyMed ›

  • Vomiting Additional detail

    Coconut

    Recorded for Coconut in the same Natural Medicines adverse-effect record shown under Shortness of breath above.

    Diethylpropion

    Listed in the ADVERSE REACTIONS section of the FDA label for Diethylpropion. Read the label on DailyMed ›

Reported for Coconut but not commonly for Diethylpropion: a severe allergic reaction, an allergic reaction, swelling and wheezing.

Effects for Diethylpropion come from the ADVERSE REACTIONS section of its FDA label; effects for Coconut come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Coconut in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in food amounts. There is insufficient reliable information available about the safety of coconut when used in medicinal amounts during pregnancy and lactation; avoid use.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Diethylpropion Is Prescribed For, and What Coconut Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Diethylpropion is a prescription medicine with approved uses on its FDA label. Coconut is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Diethylpropion is prescribed for: Diethylpropion is used to help manage exogenous obesity (excess body weight from outside factors like diet) in adults with a body mass index (BMI) of 30 or higher who haven't lost enough weight through diet and exercise alone. It is meant to be used for only a few weeks as part of a calorie-restricted diet plan. All available tablet products — both the immediate-release tablets and the extended-release tablets — are approved for this purpose. Each is approved for use as a single medication only; combining diethylpropion with any other weight-loss drug is not allowed.

Coconut has been studied for:

  • Obesity studied, not established Coconut has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Coconut for obesity

    Although there is interest in using oral coconut for weight loss, there is insufficient reliable information about the clinical effects of coconut for this condition.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Diethylpropion on your own; if you are taking Coconut for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Coconut or Diethylpropion

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Coconut or Diethylpropion, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Diethylpropion

This page covers Coconut only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diethylpropion page lists 61 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Peyote (major), Rauvolfia Vomitoria (major) and Sida Cordifolia (major).

By severity: 5 major · 43 moderate · 13 minor.

From our pharmacist’s overview on the Diethylpropion page

“Diethylpropion (Tenuate) is an appetite suppressant that works by revving up the nervous system, and that mechanism is why its interaction list calls for real vigilance. Of the 61 supplements and herbs on file, 44 add their own stimulant push, raising the risk of high blood pressure, a pounding heart, and sleeplessness.”

Reviewed by 2 · Jul 18, 2026

Open the Diethylpropion interaction page

One more smart check

Taking Coconut as Part of a Dietary Supplement Product? Check It for Interactions

We hold 806 real supplement products containing Coconut, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Coconut. Even though Coconut itself has no known interaction with Diethylpropion, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Coconut and Diethylpropion Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Coconut
Top 25%

#181 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diethylpropion
Steady interest

#1,450 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Coconut reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Coconut and Diethylpropion records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Coconut

What is Coconut?

  • Skin and hair care
  • Source of dietary fats (MCTs)
  • Hydration with coconut water
  • Cooking and weight management
  • Antimicrobial (traditional use)

Coconut is a nutritious tropical food enjoyed as oil, water, milk, and flesh, and it is generally safe to eat in normal food amounts. While some uses (like skin moisturizing and hydration) have reasonable support, many health claims for coconut oil are weak or unproven, and coconut oil is high in saturated fat. Talk with your pharmacist or doctor before using coconut products in large or medicinal amounts.

Cocos nucifera · Arecaceae · Fruit (flesh and water), oil, and milk · Coconut oil, coconut water, coconut milk, dried/shredded flesh, capsules (MCT oil)

An interaction check asks whether these two react with each other — it does not ask whether Coconut is a good idea for someone in your situation. Here is what our Coconut record says about it on its own.

Coconut: dosing

There is no standardized medicinal dose for coconut products. As a food, coconut oil, water, milk, and flesh are used in everyday cooking and drinking amounts.If you use a coconut or MCT oil supplement, follow the directions on the product label.

From our Coconut monograph — the full record covers uses, side effects and every documented interaction.

Read the full Coconut monograph & all interactions
Medication

About Diethylpropion

What Is Diethylpropion Used For?

Brand names: Radtue, Tenuate, Durad, Tenuate Dosepan

Diethylpropion is used to help manage exogenous obesity (excess body weight from outside factors like diet) in adults with a body mass index (BMI) of 30 or higher who haven't lost enough weight through diet and exercise alone. It is meant to be used for only a few weeks as part of a calorie-restricted diet plan.

All available tablet products — both the immediate-release tablets and the extended-release tablets — are approved for this purpose. Each is approved for use as a single medication only; combining diethylpropion with any other weight-loss drug is not allowed.

See full Diethylpropion drug information
Keep checking

Other Drugs & Coconut

Browse every other medication we’ve checked against Coconut — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
86Minor
2,743No known interaction
86 Minor 2,743 No interaction
Minor

86 interactions

Showing 60 of 86 minor interactions — see all 86 on the Coconut page.

No interaction 2,743 drugs checked — show the list

We also checked Coconut against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Coconut list.

See the full Coconut interactions page
See every supplement checked against Diethylpropion, ranked by severity
Evidence & sources

Coconut References

The 10 references that drive our Coconut monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Teuber SS, Peterson WR. Systemic allergic reaction to coconut (Cocos nucifera) in 2 subjects with hypersensitivity to tree nut and demonstration of cross-reactivity to legumin-like seed storage proteins: new coconut and walnut food allergens. J Allergy Cl PubMed
  2. Rosado A, Fernandez-Rivas M, Gonzalez-Mancebo E, et al. Anaphylaxis to coconut. Allergy 2002;57(2):182-3. PubMed
  3. Karmakar PR, Das A, Chatterjee BP. Placebo-controlled immunotherapy with Cocos nucifera pollen extract. Int Arch Allergy Immunol 1994;103(2):194-201. PubMed
  4. Anagnostou K. Coconut Allergy Revisited. Children (Basel). 2017;4(10). pii: E85. PubMed
  5. Cifuentes L, Mistrello G, Amato S, et al. Identification of cross-reactivity between buckwheat and coconut. Ann Allergy Asthma Immunol. 2015;115(6):530-2. PubMed
  6. Michavila Gomez A, Amat Bou M, Gonzalez Cortés MV, Segura Navas L, Moreno Palanques MA, Bartolomé B. Coconut anaphylaxis: Case report and review. Allergol Immunopathol (Madr). 2015;43(2):219-20. PubMed
  7. 21CFR170.3. U.S. Food and Drug Administration Department of Health and Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=170.3
  8. Alatawi KA, Alshubaily FA. Coconut products alleviate hyperglycaemic, hyperlipidimic and nephropathy indices in streptozotocin-induced diabetic wistar rats. Saudi J Biol Sci. 2021;28(8):4224-4231. PubMed
  9. Kruse L, Lor J, Yousif R, Pongracic JA, Fishbein AB. Coconut allergy: Characteristics of reactions and diagnostic predictors in a pediatric tertiary care center. Ann Allergy Asthma Immunol 2021;126(5):562-568.
  10. Pathmanandavel K, Kaur N, Joshi P, Ford LS. Anaphylaxis and allergy to coconut: An Australian pediatric case series. J Allergy Clin Immunol Pract 2020;8(10):3657-3659. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Coconut and Diethylpropion Together: Common Questions

Is it safe to take Coconut with Diethylpropion?
We do not list a known interaction between Coconut and Diethylpropion. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Coconut and Diethylpropion have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Coconut and Diethylpropion used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Coconut in each. That is a conversation for your prescriber, especially if Diethylpropion is being adjusted to a target.
How was the Coconut and Diethylpropion combination checked?
Interactions in our licensed database are recorded against drug classes. Diethylpropion is filed under 2 classifications, and Coconut has documented interactions with 1 drug class — none of Diethylpropion's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Coconut interact with any other medications?
Yes. Coconut has 86 documented drug interactions in our database — Diethylpropion is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Diethylpropion interact with any supplements?
Yes. Diethylpropion has documented interactions with 61 supplements in our database — Coconut is not one of them. The Diethylpropion interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Coconut monograph Uses, safety profile, and every drug interaction in one place Diethylpropion drug information The full plain-English guide to this medication Diethylpropion supplement interactions Every supplement checked against Diethylpropion, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 10 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diethylpropion and Coconut?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.