Drug & supplement interaction

Gymnema + Diethylpropion

Diethylpropion brand names: Radtue, Tenuate, Durad, Tenuate Dosepan.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Gymnema and Diethylpropion in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Gymnema and Diethylpropion

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Diethylpropion and Gymnema in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Gymnema safety at a glance

Gymnema overall Use caution Generally well tolerated short-term, but it can lower blood sugar and quality varies between products.

Pregnancy Avoid Not enough safety data, so it is best avoided during pregnancy.

Breastfeeding Avoid Not enough safety data, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Diethylpropion and Gymnema? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Diethylpropion

Interactions in our licensed database are recorded against drug classes, not just single drug names. Diethylpropion is filed under 2 classifications — stimulant drugs, oral drugs. Gymnema has documented interactions with 6 drug classes — the most serious being antidiabetes drugs (moderate), cytochrome p450 1a2 (cyp1a2) substrates (moderate) and cytochrome p450 2c9 (cyp2c9) substrates (moderate) — and none of Diethylpropion’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Gymnema Does Interact With Other Medications

Gymnema has 347 moderate, 504 minor known drug interactions in our database — Diethylpropion isn’t one of them. If you take anything else, check it against the full list below.

Moderate 347 Minor 504 No known interaction 1,979 (incl. Diethylpropion)

Taking anything else?

Check Another of Your Medications Against Gymnema

Covers the 2,830 medications we’ve checked against Gymnema. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Gymnema and Diethylpropion May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

Tiredness Additional detail
Gymnema
“A case of drug-induced hepatitis characterized by weakness, fatigue, jaundice, and elevated liver enzymes, has been reported for a patient who consumed gymnema tea three times daily for 10 days. The patient was administered prednisone 60 mg once daily and was eventually tapered off prednisone and discharged. Laboratory values normalized after 6 months.”

Gymnema · Natural Medicines adverse-effect record, reported in anemia.
2 sources cited

95005. Shiyovich A, Sztarkier I, Nesher L. Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus. Am J Med Sci. 2010;340(6):514-7. PubMed

110021. Philips CA, Theruvath AH, Ravindran R. Toxic hepatitis-associated aplastic anaemia after dual homeopathic remedies and Gymnema sylvestre use. BMJ Case Rep 2022;15(3):e247867. PubMed
Diethylpropion

Listed in the ADVERSE REACTIONS section of the FDA label for Diethylpropion. Read the label on DailyMed ›

Reported for Gymnema but not commonly for Diethylpropion: liver problems, yellowing of the skin or eyes and anemia.

Effects for Diethylpropion come from the ADVERSE REACTIONS section of its FDA label; effects for Gymnema come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Diethylpropion Is Prescribed For, and What Gymnema Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Diethylpropion is a prescription medicine with approved uses on its FDA label. Gymnema is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Diethylpropion is prescribed for: Diethylpropion is used to help manage exogenous obesity (excess body weight from outside factors like diet) in adults with a body mass index (BMI) of 30 or higher who haven't lost enough weight through diet and exercise alone. It is meant to be used for only a few weeks as part of a calorie-restricted diet plan. All available tablet products — both the immediate-release tablets and the extended-release tablets — are approved for this purpose. Each is approved for use as a single medication only; combining diethylpropion with any other weight-loss drug is not allowed.

Gymnema has been studied for:

Obesity studied, not established Gymnema has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Gymnema for obesity

It is unclear if oral gymnema improves weight loss in overweight or obese adults.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Diethylpropion on your own; if you are taking Gymnema for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Diethylpropion

This page covers Gymnema only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diethylpropion page lists 61 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Ephedra (major), Peyote (major), Rauvolfia Vomitoria (major) and Sida Cordifolia (major).

By severity: 5 major · 43 moderate · 13 minor.

From our pharmacist’s overview on the Diethylpropion page

“Diethylpropion (Tenuate) is an appetite suppressant that works by revving up the nervous system, and that mechanism is why its interaction list calls for real vigilance. Of the 61 supplements and herbs on file, 44 add their own stimulant push, raising the risk of high blood pressure, a pounding heart, and sleeplessness.”

Reviewed by 2 · Jul 18, 2026

Open the Diethylpropion interaction page

One more smart check

Taking Gymnema as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,084 real supplement products containing Gymnema, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Gymnema. Even though Gymnema itself has no known interaction with Diethylpropion, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Gymnema and Diethylpropion Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Gymnema

Top 25%

#181 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Diethylpropion

Steady interest

#2,488 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Gymnema reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Gymnema and Diethylpropion records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Gymnema

What is Gymnema?

Blood sugar support
Type 2 diabetes
Sugar cravings
Weight management
Cholesterol support

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human studies are encouraging for blood sugar support, but the evidence is still limited and not strong enough to replace standard treatment. If you have diabetes or take other medicines, talk with your pharmacist or doctor before using it.

Gymnema sylvestre · Apocynaceae · Leaves (and sometimes the root) · Capsules, tablets, powders, liquid extracts, teas, and chewable lozenges

An interaction check asks whether these two react with each other — it does not ask whether Gymnema is a good idea for someone in your situation. Here is what our Gymnema record says about it on its own.

Gymnema: dosing

There is no official or universally agreed-upon dose for gymnema. The right amount depends on the product, the type of extract, and how it is standardized.Many supplements are standardized to gymnemic acid content, and doses in studies have varied widely. They can help you choose a reputable product, decide on an appropriate amount, and make sure it is safe with your current health conditions and medicines.

From our Gymnema monograph — the full record covers uses, side effects and every documented interaction.

Read the full Gymnema monograph & all interactions

Medication

About Diethylpropion

What Is Diethylpropion Used For?

Brand names: Radtue, Tenuate, Durad, Tenuate Dosepan

Diethylpropion is used to help manage exogenous obesity (excess body weight from outside factors like diet) in adults with a body mass index (BMI) of 30 or higher who haven't lost enough weight through diet and exercise alone. It is meant to be used for only a few weeks as part of a calorie-restricted diet plan.

All available tablet products — both the immediate-release tablets and the extended-release tablets — are approved for this purpose. Each is approved for use as a single medication only; combining diethylpropion with any other weight-loss drug is not allowed.

See full Diethylpropion drug information

Keep checking

Other Drugs & Gymnema

Browse every other medication we’ve checked against Gymnema — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

347Moderate

504Minor

1,978No known interaction

347 Moderate 504 Minor 1,978 No interaction

Moderate

347 interactions

Showing 60 of 347 moderate interactions — see all 347 on the Gymnema page.

Minor

504 interactions

Showing 60 of 504 minor interactions — see all 504 on the Gymnema page.

No interaction 1,978 drugs checked — show the list

We also checked Gymnema against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,978 medications checked with no known interaction — see the full Gymnema list.

See the full Gymnema interactions page

See every supplement checked against Diethylpropion, ranked by severity

Evidence & sources

Gymnema References

The 12 references that drive our Gymnema monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Shanmugasundaram ER, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;30:281-94. PubMed
Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol 1990;30:295-300.
Kamble B, Gupta A, Moothedath I, Khatal L, Janrao S, Jadhav A, et al. Effects of Gymnema sylvestre extract on the pharmacokinetics and pharmacodynamics of glimepiride in streptozotocin induced diabetic rats. Chem Biol Interact. 2016;245:30-8. PubMed
Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int. 2014; 2014:830285.
Fabio GD, Romanucci V, De Marco A, Zarrelli A. Triterpenoids from Gymnema sylvestre and their pharmacological activities. Molecules. 2014;19(8):10956-81. PubMed
Shiyovich A, Sztarkier I, Nesher L. Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus. Am J Med Sci. 2010;340(6):514-7. PubMed
Zuniga LY, Gonzalez-Ortiz M, Martinez-Abundis E. Effect of gymnema sylvestre administration on metabolic syndrome, insulin sensitivity, and insulin secretion. J Med Food. 2017 Aug;20(8):750-54.
Rammohan B, Samit K, Chinmoy D, et al. Human cytochrome P450 enzyme modulation by gymnema sylvestre: a predictive safety evaluation by LC-MS/MS. Pharmacogn Mag. 2016 Jul;12(Suppl 4):S389-S394.
Vaghela M, Sahu N, Kharkar P, Pandita N. In vivo pharmacokinetic interaction by ethanolic extract of gymnema sylvestre with CYP2C9 (tolbutamide), CYP3A4 (amlodipine) and CYP1A2 (phenacetin) in rats. Chem Biol Interact. 2017 Dec 25;278:141-151. PubMed
Vaghela M, Iyer K, Pandita N. In vitro inhibitory effect of gymnema sylvestre extracts and total gymnemic acids fraction on select cytochrome P450 activities in rat liver microsomes. Eur J Drug Metab Pharmacokinet. 2017 Oct 10. PubMed
Gaytán Martínez LA, Sánchez-Ruiz LA, Zuñiga LY, González-Ortiz M, Martínez-Abundis E. Effect of Gymnema sylvestre administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance. J Med Food. 2021;
Philips CA, Theruvath AH, Ravindran R. Toxic hepatitis-associated aplastic anaemia after dual homeopathic remedies and Gymnema sylvestre use. BMJ Case Rep 2022;15(3):e247867. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Gymnema and Diethylpropion Together: Common Questions

Is it safe to take Gymnema with Diethylpropion?

We do not list a known interaction between Gymnema and Diethylpropion. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Gymnema and Diethylpropion have any of the same side effects?

Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Are Gymnema and Diethylpropion used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Gymnema in each. That is a conversation for your prescriber, especially if Diethylpropion is being adjusted to a target.

How was the Gymnema and Diethylpropion combination checked?

Interactions in our licensed database are recorded against drug classes. Diethylpropion is filed under 2 classifications, and Gymnema has documented interactions with 6 drug classes — none of Diethylpropion's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Gymnema interact with any other medications?

Yes. Gymnema has 851 documented drug interactions in our database — Diethylpropion is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Diethylpropion interact with any supplements?

Yes. Diethylpropion has documented interactions with 61 supplements in our database — Gymnema is not one of them. The Diethylpropion interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Gymnema monograph Uses, safety profile, and every drug interaction in one place Diethylpropion drug information The full plain-English guide to this medication Diethylpropion supplement interactions Every supplement checked against Diethylpropion, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 12 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Diethylpropion and Gymnema?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.