Medication interaction hub

What Supplements Interact with Ecstasy?

Ecstasy brand name: MDMA. Every interaction below applies to the brands too.

66 Interactions 5 Major 48 Moderate 13 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ecstasy? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ecstasy against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

MDMA (Ecstasy) already drives heart rate, blood pressure, and body temperature upward, so the 66 interacting supplements and herbs listed here call for real caution, and the five rated major matter most. The bulk of the list, 44 ingredients, adds stimulant effects to MDMA's own. Ephedra is the most hazardous of these, while ordinary caffeine accounts for a large share of the 48 moderate entries.

A separate group of 17 changes how much of an oral dose is actually absorbed. Activated charcoal, another of the majors, binds many drugs in the gut and can sharply cut their levels, and bulky fibers slow uptake too. Six more ingredients can lower the seizure threshold, meaning seizures become easier to trigger, a real concern with a drug that already strains the nervous system. Thirteen minor entries round out the count, but the ephedra-type stimulant combinations are where the sharpest risk sits.

— , Clinical Pharmacist · July 18, 2026

Major 5 Moderate 48 Minor 13 No known interaction 1,386

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ecstasy: Top Interactions at a Glance

The Ecstasy supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 66 interacting ingredients — plus 1,386 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ecstasy Combinations Today

The Ecstasy + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Coffee + Ecstasyi

Theoretically, concomitant use might increase stimulant adverse effects.

Read the full interaction Moderate Likelihood Possible Melatonin + Ecstasyi

Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Read the full interaction Moderate Likelihood Possible Slippery Elm + Ecstasyi

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Read the full interaction Minor Likelihood Possible N-methyltyramine + Ecstasyi

N-methyltyramine is thought to have stimulant effects.

Read the full interaction Major Likelihood Probable Activated Charcoal + Ecstasyi

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Ephedra + Ecstasyi

Theoretically, concomitant use might increase the risk for serious adverse effects.

Read the full interaction
The complete list

Every Supplement Checked Against Ecstasy

All 1,452 ingredients in our database, ranked by severity — 66 with a Ecstasy interaction on file and 1,386 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ecstasy?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Coffee with Ecstasy?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase stimulant adverse effects.

Full Coffee + Ecstasy answer

Can you take Melatonin with Ecstasy?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Ecstasy answer

Can you take Slippery Elm with Ecstasy?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Ecstasy answer

Can you take N-methyltyramine with Ecstasy?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. N-methyltyramine is thought to have stimulant effects.

Full N-methyltyramine + Ecstasy answer

Can you take Khat with Ecstasy?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Cathinone, a constituent of khat, appears to have sympathomimetic effects and can increase blood pressure and heart rate.

Full Khat + Ecstasy answer

Can you take Methylsynephrine with Ecstasy?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Methylsynephrine has cardiac stimulant effects.

Full Methylsynephrine + Ecstasy answer

Can you take Panax Ginseng with Ecstasy?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Panax ginseng with stimulant drugs might increase the risk of adverse stimulant effects.

Full Panax Ginseng + Ecstasy answer

Can you take Phenpromethamine with Ecstasy?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking phenpromethamine with stimulant drugs might have additive effects and increase the risk of adverse cardiovascular effe...

Full Phenpromethamine + Ecstasy answer

Can you take Raspberry Ketone with Ecstasy?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, raspberry ketone might increase the risk of adverse cardiovascular effects with stimulant drugs.

Full Raspberry Ketone + Ecstasy answer

Can you take Rauwolscine with Ecstasy?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Ecstasy answer

Can you take Securinega Suffruticosa with Ecstasy?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Securinega suffruticosa with stimulant drugs might increase the risk of serious adverse effects.

Full Securinega Suffruticosa + Ecstasy answer

Can you take Thuja with Ecstasy?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Ecstasy answer

Can you take Tragacanth with Ecstasy?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Ecstasy answer

Can you take Yohimbe with Ecstasy?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking yohimbe with stimulant drugs can have additive effects.

Full Yohimbe + Ecstasy answer

Can you take Thyroid Extract with Ecstasy?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Ecstasy answer

Can you take Agar with Ecstasy?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Ecstasy answer

Can you take Algin with Ecstasy?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Ecstasy answer

Can you take Black Psyllium with Ecstasy?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Ecstasy answer

Can you take Blond Psyllium with Ecstasy?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Ecstasy answer

Can you take Carob with Ecstasy?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Ecstasy answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ecstasy is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ecstasy, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ecstasy sits in 3 interaction categories. Open any one to see what the group means:

Stimulant Drugs 44 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

44 of the supplement ingredients on this page reach Ecstasy through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ecstasy through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Ecstasy through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ecstasy

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ecstasy.

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Pharmacist Counseling Corner

Ecstasy & Supplements: Common Questions

What supplements interact with Ecstasy?
More than you might expect — 66 in total, though they are far from equal: 5 are rated major, 48 moderate, and 13 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Activated Charcoal, Ephedra, Peyote.
Which Ecstasy supplement interactions are the most serious?
The 5 major-rated combinations — led by Activated Charcoal, Ephedra, Peyote, Rauvolfia Vomitoria and Sida Cordifolia — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Ecstasy?
Usually yes — most people on Ecstasy can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like MDMA have the same supplement interactions as Ecstasy?
Yes — MDMA all contain Ecstasy, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Ecstasy and my other medications?
This page covers Ecstasy against supplements and herbal ingredients. Checking Ecstasy against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.