Drug & supplement interaction

Black Nightshade + Ethinyl Estradiol, Norgestimate

Ethinyl Estradiol, Norgestimate brand names: Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Ortho-Cyclen, Mononessa, Previfem, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Black Nightshade and Ethinyl Estradiol, Norgestimate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Black Nightshade and Ethinyl Estradiol, Norgestimate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ethinyl Estradiol, Norgestimate and Black Nightshade in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Black Nightshade at all — not against Ethinyl Estradiol, Norgestimate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Black Nightshade safety at a glance

Black Nightshade overall Use caution Unripe berries and green parts can be toxic; only fully ripe fruit or properly cooked leaves are traditionally considered safer.
Pregnancy Likely Unsafe When used orally because of concerns it could be teratogenic; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally because of concerns it could be teratogenic; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ethinyl Estradiol, Norgestimate and Black Nightshade? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Ethinyl Estradiol, Norgestimate’s Own FDA Label Lists

This is not an interaction — none of it involves Black Nightshade. These are the most notable effects listed in the ADVERSE REACTIONS section of Ethinyl Estradiol, Norgestimate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • A heart attack Worth acting on
  • Blood clots Worth acting on
  • Low mood Worth acting on
  • Raised blood pressure Worth acting on
  • A higher chance of infection Worth acting on
  • Changes to your period
  • Breast tenderness
  • Migraine
  • Weight gain
  • Mood changes or irritability

Showing the 10 most notable of 16 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Ethinyl Estradiol, Norgestimate. Read the label on DailyMed › Black Nightshade’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Black Nightshade side to compare — that is a limit of the record, not a statement that Black Nightshade has no side effects.

Special populations

Black Nightshade in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When used orally because of concerns it could be teratogenic; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Ethinyl Estradiol, Norgestimate

This page covers Black Nightshade only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ethinyl Estradiol, Norgestimate page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 195 moderate · 38 minor.

Open the Ethinyl Estradiol, Norgestimate interaction page

One more smart check

Taking Black Nightshade as Part of a Dietary Supplement Product? Check It for Interactions

We hold 37 real supplement products containing Black Nightshade, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Black Nightshade. Even though Black Nightshade itself has no known interaction with Ethinyl Estradiol, Norgestimate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Black Nightshade and Ethinyl Estradiol, Norgestimate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Black Nightshade
Steady interest

#733 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ethinyl Estradiol, Norgestimate
Steady interest

#1,696 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Nightshade reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Black Nightshade and Ethinyl Estradiol, Norgestimate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Black Nightshade

What is Black Nightshade?

Black Nightshade
  • Digestive complaints
  • Skin conditions
  • Inflammation
  • Fever
  • Liver support (traditional)

Black nightshade is a wild plant whose cooked ripe berries and leaves are eaten as food in some cultures, but unripe berries and green parts can be poisonous. Human evidence for any health benefit is very limited, and the risk of toxicity is real. Do not use it as a supplement without medical guidance, and avoid it during pregnancy and breastfeeding.

Solanum nigrum · Solanaceae · Leaves, berries (ripe), and whole plant · Cooked leafy greens, fruit, traditional decoctions, dried herb, extracts

An interaction check asks whether these two react with each other — it does not ask whether Black Nightshade is a good idea for someone in your situation. Here is what our Black Nightshade record says about it on its own.

Black Nightshade: dosing

There is no established or standardized safe dose of black nightshade as a supplement. When it comes to wild plants, never guess at an amount or forage your own to use as medicine.

From our Black Nightshade monograph — the full record covers uses, side effects and every documented interaction.

Read the full Black Nightshade monograph & all interactions
Keep checking

Other Drugs & Black Nightshade

Browse every other medication we’ve checked against Black Nightshade — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Black Nightshade against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Black Nightshade list.

See the full Black Nightshade interactions page
See every supplement checked against Ethinyl Estradiol, Norgestimate, ranked by severity
Evidence & sources

Black Nightshade References

The 1 references that drive our Black Nightshade monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Dukes JA. CRC Handbook of Medicinal Herbs. first ed. Boca Raton, FL: CRC Press, Inc., 1985.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Black Nightshade and Ethinyl Estradiol, Norgestimate Together: Common Questions

Is it safe to take Black Nightshade with Ethinyl Estradiol, Norgestimate?
We do not list a known interaction between Black Nightshade and Ethinyl Estradiol, Norgestimate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Ethinyl Estradiol, Norgestimate interact with any supplements?
Yes. Ethinyl Estradiol, Norgestimate has documented interactions with 239 supplements in our database — Black Nightshade is not one of them. The Ethinyl Estradiol, Norgestimate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Black Nightshade monograph Uses, safety profile, and every drug interaction in one place Ethinyl Estradiol, Norgestimate supplement interactions Every supplement checked against Ethinyl Estradiol, Norgestimate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ethinyl Estradiol, Norgestimate and Black Nightshade?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.