Medication interaction hub

What Supplements Interact with Ethinyl Estradiol, Norgestimate?

Ethinyl Estradiol, Norgestimate brand names: Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Ortho-Cyclen, Mononessa, Previfem, and others. Every interaction below applies to the brands too.

239 Interactions 6 Major 195 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ethinyl Estradiol, Norgestimate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ethinyl Estradiol, Norgestimate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

239 supplements and herbal ingredients have interactions with Ethinyl Estradiol, Norgestimate on file in the HelloPharmacist interaction database — 6 rated major, 195 moderate, and 38 minor. The most serious involve Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort.

Our assessment: with 6 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Ethinyl Estradiol, Norgestimate.

Major 6 Moderate 195 Minor 38 No known interaction 1,213

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ethinyl Estradiol, Norgestimate: Top Interactions at a Glance

The Ethinyl Estradiol, Norgestimate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 239 interacting ingredients — plus 1,213 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ethinyl Estradiol, Norgestimate Combinations Today

The Ethinyl Estradiol, Norgestimate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Ginger + Ethinyl Estradiol, Norgestimatei

Ginger might increase or decrease the levels of CYP3A4 substrates.

Read the full interaction Minor Likelihood Possible Copper + Ethinyl Estradiol, Norgestimatei

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.

Read the full interaction Moderate Likelihood Possible Black Pepper + Ethinyl Estradiol, Norgestimatei

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Oregon Grape + Ethinyl Estradiol, Norgestimatei

Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.

Read the full interaction Moderate Likelihood Possible Brussels Sprout + Ethinyl Estradiol, Norgestimatei

Animal research suggests that Brussels sprout can induce cytochrome P450 1A2 (CYP1A2) activity.

Read the full interaction Major Likelihood Likely Grapefruit + Ethinyl Estradiol, Norgestimatei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Ethinyl Estradiol, Norgestimate

All 1,452 ingredients in our database, ranked by severity — 239 with a Ethinyl Estradiol, Norgestimate interaction on file and 1,213 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ethinyl Estradiol, Norgestimate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Ginger with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ginger might increase or decrease the levels of CYP3A4 substrates.

Full Ginger + Ethinyl Estradiol, Norgestimate answer

Can you take Copper with Ethinyl Estradiol, Norgestimate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.

Full Copper + Ethinyl Estradiol, Norgestimate answer

Can you take Black Pepper with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.

Full Black Pepper + Ethinyl Estradiol, Norgestimate answer

Can you take Oregon Grape with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.

Full Oregon Grape + Ethinyl Estradiol, Norgestimate answer

Can you take Brussels Sprout with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that Brussels sprout can induce cytochrome P450 1A2 (CYP1A2) activity.

Full Brussels Sprout + Ethinyl Estradiol, Norgestimate answer

Can you take Goldthread with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's very preliminary evidence that berberine, a constituent of goldthread, might inhibit cytochrome P450 3A4 (CYP3A4) enzyme.

Full Goldthread + Ethinyl Estradiol, Norgestimate answer

Can you take Gotu Kola with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gotu kola with hepatotoxic drugs might have additive adverse effects.

Full Gotu Kola + Ethinyl Estradiol, Norgestimate answer

Can you take Grape with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, grape juice might reduce the levels of CYP1A2 substrates.

Full Grape + Ethinyl Estradiol, Norgestimate answer

Can you take Greater Celandine with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that greater celandine can adversely affect the liver.

Full Greater Celandine + Ethinyl Estradiol, Norgestimate answer

Can you take Guar Gum with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Ethinyl Estradiol, Norgestimate answer

Can you take Gum Arabic with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Ethinyl Estradiol, Norgestimate answer

Can you take Gymnema with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.

Full Gymnema + Ethinyl Estradiol, Norgestimate answer

Can you take Hemp with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Full Hemp + Ethinyl Estradiol, Norgestimate answer

Can you take Hemp Agrimony with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Hemp agrimony contains hepatotoxic pyrrolizidine alkaloids (PA).

Full Hemp Agrimony + Ethinyl Estradiol, Norgestimate answer

Can you take Hesperidin with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hesperidin might inhibit P-glycoprotein-mediated drug efflux and potentially increase levels of drugs that are substrates of...

Full Hesperidin + Ethinyl Estradiol, Norgestimate answer

Can you take Higenamine with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the levels and clinical effects drugs metabolized by CYP3A4.

Full Higenamine + Ethinyl Estradiol, Norgestimate answer

Can you take Hops with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen rec...

Full Hops + Ethinyl Estradiol, Norgestimate answer

Can you take Horny Goat Weed with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.

Full Horny Goat Weed + Ethinyl Estradiol, Norgestimate answer

Can you take Hu Zhang with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.

Full Hu Zhang + Ethinyl Estradiol, Norgestimate answer

Can you take Indian Long Pepper with Ethinyl Estradiol, Norgestimate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Indian long pepper might increase the effects and adverse effects of CYP3A4 substrates.

Full Indian Long Pepper + Ethinyl Estradiol, Norgestimate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ethinyl Estradiol, Norgestimate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ethinyl Estradiol, Norgestimate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ethinyl Estradiol, Norgestimate sits in 11 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Ethinyl Estradiol, Norgestimate through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Ethinyl Estradiol, Norgestimate through this category.

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Ethinyl Estradiol, Norgestimate through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Ethinyl Estradiol, Norgestimate through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Ethinyl Estradiol, Norgestimate through this category.

Contraceptive Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Ethinyl Estradiol, Norgestimate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ethinyl Estradiol, Norgestimate through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Ethinyl Estradiol, Norgestimate through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Ethinyl Estradiol, Norgestimate through this category.

Ethinyl Estradiol 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Ethinyl Estradiol, Norgestimate through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Ethinyl Estradiol, Norgestimate through this category.

Related: does Ethinyl Estradiol, Norgestimate deplete any nutrients?

Ethinyl Estradiol, Norgestimate has 77 reported nutrient associations in the research literature — see the Ethinyl Estradiol, Norgestimate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ethinyl Estradiol, Norgestimate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ethinyl Estradiol, Norgestimate.

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Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

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Pharmacist Counseling Corner

Ethinyl Estradiol, Norgestimate & Supplements: Common Questions

What supplements interact with Ethinyl Estradiol, Norgestimate?
Our database currently documents 239 ingredients with a known Ethinyl Estradiol, Norgestimate interaction (6 major, 195 moderate, 38 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 239. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Ethinyl Estradiol, Norgestimate supplement interactions are the most serious?
Focus on the major group: Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort, among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Ethinyl Estradiol, Norgestimate?
Plenty of supplements coexist fine with Ethinyl Estradiol, Norgestimate; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Ortho Tri-Cyclen 28 have the same supplement interactions as Ethinyl Estradiol, Norgestimate?
Yes — Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Ortho-Cyclen, Mononessa, Previfem and other brands all contain Ethinyl Estradiol, Norgestimate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Ethinyl Estradiol, Norgestimate deplete any vitamins or nutrients?
It might — Ethinyl Estradiol, Norgestimate has 77 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Ethinyl Estradiol, Norgestimate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Ethinyl Estradiol, Norgestimate and my other medications?
This page covers Ethinyl Estradiol, Norgestimate against supplements and herbal ingredients. Checking Ethinyl Estradiol, Norgestimate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.