Drug & supplement interaction

Red Maple + Ethinyl Estradiol, Norgestimate

Ethinyl Estradiol, Norgestimate brand names: Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Ortho-Cyclen, Mononessa, Previfem, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Red Maple and Ethinyl Estradiol, Norgestimate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Red Maple and Ethinyl Estradiol, Norgestimate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ethinyl Estradiol, Norgestimate and Red Maple in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Red Maple at all — not against Ethinyl Estradiol, Norgestimate, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Red Maple safety at a glance

Red Maple overall Not established Human safety data is very limited, so use cautiously and only under guidance.
Pregnancy Avoid There is not enough safety information, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid medicinal use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ethinyl Estradiol, Norgestimate and Red Maple? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Ethinyl Estradiol, Norgestimate’s Own FDA Label Lists

This is not an interaction — none of it involves Red Maple. These are the most notable effects listed in the ADVERSE REACTIONS section of Ethinyl Estradiol, Norgestimate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • A heart attack Worth acting on
  • Blood clots Worth acting on
  • Low mood Worth acting on
  • Raised blood pressure Worth acting on
  • A higher chance of infection Worth acting on
  • Changes to your period
  • Breast tenderness
  • Migraine
  • Weight gain
  • Mood changes or irritability

Showing the 10 most notable of 16 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Ethinyl Estradiol, Norgestimate. Read the label on DailyMed › Red Maple’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Red Maple side to compare — that is a limit of the record, not a statement that Red Maple has no side effects.

Everything else you take

See Every Supplement That Interacts With Ethinyl Estradiol, Norgestimate

This page covers Red Maple only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ethinyl Estradiol, Norgestimate page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 195 moderate · 38 minor.

Open the Ethinyl Estradiol, Norgestimate interaction page

How much people look this up

Where Red Maple and Ethinyl Estradiol, Norgestimate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Red Maple
Top 25%

#363 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ethinyl Estradiol, Norgestimate
Steady interest

#1,684 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources.
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Red Maple and Ethinyl Estradiol, Norgestimate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Red Maple

What is Red Maple?

  • Eye and skin irritation (traditional washes)
  • Coughs and sore throat
  • Digestive complaints
  • General tonic
  • Source of edible sap and syrup

Red maple is a common North American tree best known as a source of maple sap, with a long history of traditional Native American medicinal use of its bark and leaves. There is very little modern human research to support any health benefit, so it should not be relied on to treat any condition. Importantly, red maple leaves are highly toxic to horses, and people should use caution and talk to a healthcare provider before using any red maple product.

Acer rubrum · Sapindaceae · Bark, leaves, and sap · Tea, bark decoction, tinctures, and sap/syrup (food use)

An interaction check asks whether these two react with each other — it does not ask whether Red Maple is a good idea for someone in your situation. Here is what our Red Maple record says about it on its own.

Red Maple: dosing

There is no established or standardized medicinal dose for red maple. Traditional preparations were made as teas or decoctions of the bark or leaves, but amounts varied widely and were not measured in a consistent way.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Red Maple monograph — the full record covers uses, side effects and every documented interaction.

Read the full Red Maple monograph & all interactions
Keep checking

Other Drugs & Red Maple

Browse every other medication we’ve checked against Red Maple — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Red Maple against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Red Maple list.

See the full Red Maple interactions page
See every supplement checked against Ethinyl Estradiol, Norgestimate, ranked by severity
Sources

Sources & How We Checked

We checked Red Maple against Ethinyl Estradiol, Norgestimate in the Natural Medicines interaction database and found no documented interaction on file. The medication overview comes from MedlinePlus, and supplement label details from the NIH Dietary Supplement Label Database.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Red Maple monograph › Uses, safety, and every drug interaction in one place Ethinyl Estradiol, Norgestimate supplement interactions › Every supplement checked against Ethinyl Estradiol, Norgestimate, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Red Maple and Ethinyl Estradiol, Norgestimate Together: Common Questions

Is it safe to take Red Maple with Ethinyl Estradiol, Norgestimate?
We do not list a known interaction between Red Maple and Ethinyl Estradiol, Norgestimate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Ethinyl Estradiol, Norgestimate interact with any supplements?
Yes. Ethinyl Estradiol, Norgestimate has documented interactions with 239 supplements in our database — Red Maple is not one of them. The Ethinyl Estradiol, Norgestimate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ethinyl Estradiol, Norgestimate and Red Maple?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.