Black Nightshade + Psyllium (OTC drug)
Psyllium (OTC drug) brand name: Metamucil.
We found no known interaction between Black Nightshade and Psyllium (OTC drug) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Black Nightshade and Psyllium (OTC drug)
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Psyllium (OTC drug) and Black Nightshade in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Black Nightshade at all — not against Psyllium (OTC drug), and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Black Nightshade safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Black Nightshade in Pregnancy & Breastfeeding
When used orally because of concerns it could be teratogenic; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Questions About Black Nightshade or Psyllium (OTC drug)
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Black Nightshade or Psyllium (OTC drug), not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Does Taking Metamucil Before Meals Prevent Hard Stools? ›
- Potassium, Fiber Interaction And Gallbladder Removal Concerns ›
- Can You Use Metamucil For IBS With Diarrhea? ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Psyllium (OTC drug)
This page covers Black Nightshade only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Psyllium (OTC drug) page lists 17 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 9 minor.
From our pharmacist’s overview on the Psyllium (OTC drug) page
“Activated charcoal tops the psyllium (Metamucil) list and is the one entry rated major. Charcoal binds many medicines in the gut and can cut how much of them reaches the body, so pairing it with anything you take by mouth deserves real caution, and I would read that entry before the rest.”
Reviewed by 2 · Jul 18, 2026
Taking Black Nightshade as Part of a Dietary Supplement Product? Check It for Interactions
We hold 37 real supplement products containing Black Nightshade, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Black Nightshade. Even though Black Nightshade itself has no known interaction with Psyllium (OTC drug), another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Black Nightshade and Psyllium (OTC drug) Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,065 of 1,452 supplements looked up here in the last 7 days
#1,572 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Nightshade reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Black Nightshade and Psyllium (OTC drug) records this page draws on were last updated June 22, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Black Nightshade
What is Black Nightshade?
- Digestive complaints
- Skin conditions
- Inflammation
- Fever
- Liver support (traditional)
Black nightshade is a wild plant whose cooked ripe berries and leaves are eaten as food in some cultures, but unripe berries and green parts can be poisonous. Human evidence for any health benefit is very limited, and the risk of toxicity is real. Do not use it as a supplement without medical guidance, and avoid it during pregnancy and breastfeeding.
Solanum nigrum · Solanaceae · Leaves, berries (ripe), and whole plant · Cooked leafy greens, fruit, traditional decoctions, dried herb, extracts
An interaction check asks whether these two react with each other — it does not ask whether Black Nightshade is a good idea for someone in your situation. Here is what our Black Nightshade record says about it on its own.
Black Nightshade: dosing
There is no established or standardized safe dose of black nightshade as a supplement. When it comes to wild plants, never guess at an amount or forage your own to use as medicine.
From our Black Nightshade monograph — the full record covers uses, side effects and every documented interaction.
About Psyllium
What Is Psyllium Used For?
Brand name: Metamucil
Psyllium is used to treat occasional constipation and help restore regularity. It is available under many brand names — including Careone, Best Choice, Premier Value Fiber, fiber laxative, meijer fiber laxative, Publix, Best Choice Fiber Therapy, Daily Fiber, Dr. Fibra, Lidl Orange Smooth Fiber Powder, and meijer fiber therapy — all for this same purpose.
Most products note that psyllium generally produces a bowel movement within 12 to 72 hours of taking a dose.
Other Drugs & Black Nightshade
Browse every other medication we’ve checked against Black Nightshade — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Black Nightshade against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Amlodipine ›
- Levothyroxine ›
- Methylphenidate ›
- Warfarin ›
- Abemaciclib ›
- Ivermectin ›
- Testosterone ›
- Sertraline ›
- Acetaminophen ›
- Losartan Potassium ›
- Aspirin ›
- Rosuvastatin ›
- Metoprolol ›
- Escitalopram ›
- Clopidogrel ›
- Rivaroxaban ›
- Atorvastatin ›
- Methamphetamine ›
- Tirzepatide ›
- Docusate ›
- Ibuprofen ›
- Warfarin Sodium ›
- Sumatriptan ›
- Valacyclovir ›
- Tadalafil ›
- Isotretinoin ›
- Hydroxyurea ›
- Prednisone ›
- Amlodipine Besylate ›
- Semaglutide ›
- Metformin ›
- Lisdexamfetamine ›
- Propranolol ›
- Amitriptyline ›
- Methotrexate ›
- Amphetamine ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Fluoxetine ›
- Doxycycline ›
- Bendamustine ›
- Levothyroxine, Liothyronine ›
- Pregabalin ›
- Azithromycin ›
- Acyclovir ›
- Lamotrigine ›
- Gabapentin ›
- Dextroamphetamine ›
- Naproxen ›
- Quetiapine ›
- Clonazepam ›
- Buspirone ›
- Omeprazole ›
- Acetaminophen, Codeine ›
- Duloxetine ›
- Letrozole ›
- Citalopram ›
- Methylene Blue ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Black Nightshade list.
Black Nightshade References
The 1 references that drive our Black Nightshade monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Dukes JA. CRC Handbook of Medicinal Herbs. first ed. Boca Raton, FL: CRC Press, Inc., 1985.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Black Nightshade and Psyllium (OTC drug) Together: Common Questions
Is it safe to take Black Nightshade with Psyllium (OTC drug)?
Does Psyllium (OTC drug) interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Still Have a Question About Psyllium (OTC drug) and Black Nightshade?
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.