Drug & supplement interaction

Blood Type Diet + Istradefylline

Istradefylline brand name: Nourianz.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Blood Type Diet and Istradefylline in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Blood Type Diet and Istradefylline

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Istradefylline and Blood Type Diet in our sources. This does not guarantee that the combination is completely free of risk — research on Blood Type Diet alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Blood Type Diet at all — not against Istradefylline, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Blood Type Diet is an eating pattern rather than something you take. Ask your pharmacist or doctor before changing how you eat while on a prescribed medicine: some medicines are dosed around meals, and a change in diet can change how they work. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Blood Type Diet safety at a glance

Blood Type Diet overall Use caution The diet itself is generally food-based, but restricting whole food groups may lead to nutrient gaps.
Pregnancy Use caution Restrictive eating plans may limit needed nutrients during pregnancy; check with your doctor first.
Breastfeeding Use caution Avoid overly restrictive versions while nursing and ensure adequate calories and nutrients.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Istradefylline and Blood Type Diet? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Istradefylline’s Own FDA Label Lists

This is not an interaction — none of it involves Blood Type Diet. These are the most notable effects listed in the ADVERSE REACTIONS section of Istradefylline’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you follow Blood Type Diet and take the medicine. 2 of them are worth acting on rather than waiting out — marked below.

  • Hallucinations Worth acting on mentioned in 10.3% of FDA reports for Istradefylline
  • High blood sugar Worth acting on
  • A change in sex drive
  • Constipation mentioned in 6.0% of FDA reports for Istradefylline
  • Reduced appetite
  • Trouble sleeping
  • Dizziness mentioned in 7.1% of FDA reports for Istradefylline
  • Diarrhea
  • A skin rash
  • Nausea

From the ADVERSE REACTIONS section of the FDA label for Istradefylline. Read the label on DailyMed › Where a percentage is shown, it is the share of 5,920 voluntary FDA FAERS reports for Istradefylline that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Blood Type Diet’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Blood Type Diet side to compare — that is a limit of the record, not a statement that Blood Type Diet has no side effects.

Everything else you take

See Every Supplement That Interacts With Istradefylline

This page covers Blood Type Diet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Istradefylline page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Istradefylline page

“Istradefylline (Nourianz) is added to levodopa to trim the daily 'off' time of Parkinson's disease, and its supplement list deserves genuine care. Most of the 138 ingredients here can change how the liver enzyme CYP3A4 handles the drug, so blood levels may drift too high or too low.”

Reviewed by 2 · Jul 18, 2026

Open the Istradefylline interaction page

How much people look this up

Where Blood Type Diet and Istradefylline Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Blood Type Diet
Steady interest

#1,359 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Istradefylline
Top half

#761 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Blood Type Diet reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Blood Type Diet and Istradefylline records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Eating pattern

About Blood Type Diet

What is Blood Type Diet?

  • Weight loss
  • General wellness
  • Heart health
  • Digestive health
  • Reducing inflammation

The Blood Type Diet claims that eating foods matched to your ABO blood type improves health and weight, but good-quality studies have not shown that blood type determines who benefits from a given diet. Any health improvements people see are more likely from simply eating more whole, unprocessed foods. Talk to a pharmacist or doctor before making big changes, especially if you have a health condition.

Eating plan (whole-food diet based on ABO blood type)

An interaction check asks whether these two react with each other — it does not ask whether Blood Type Diet is a good idea for someone in your situation. Here is what our Blood Type Diet record says about it on its own.

Blood Type Diet: dosing

There is no "dose" for the Blood Type Diet — it is an eating pattern, not a pill. Followers are given food lists for their blood type and adjust meals accordingly.If you want to try it, focus on the healthy parts (more whole foods, fewer processed foods) and make sure you still get a full range of nutrients. A pharmacist, doctor, or registered dietitian can help you plan a balanced version and decide whether any supplement, such as a multivitamin, is needed.

From our Blood Type Diet monograph — the full record covers uses, side effects and every documented interaction.

Read the full Blood Type Diet monograph & all interactions
Medication

About Istradefylline

What Is Istradefylline Used For?

Brand name: Nourianz

Nourianz (istradefylline) is used alongside levodopa/carbidopa in adults with Parkinson's disease. Specifically, it is meant to reduce 'off' episodes — periods when levodopa stops working as well and Parkinson's symptoms return or worsen.

It is an add-on therapy only; it is not used alone or as a replacement for levodopa/carbidopa.

Most-Reported Side Effects for Istradefylline

From FAERS, the FDA’s public side-effect reporting system (5,920 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hallucination 608 reports
Dyskinesia 482 reports
Dizziness 421 reports
Constipation 353 reports
Fall 344 reports
See full Istradefylline drug information
Keep checking

Other Drugs & Blood Type Diet

Browse every other medication we’ve checked against Blood Type Diet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Blood Type Diet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Blood Type Diet list.

See the full Blood Type Diet interactions page
See every supplement checked against Istradefylline, ranked by severity
Evidence & sources

Blood Type Diet References

The 1 references that drive our Blood Type Diet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Barnard ND, Rembert E, Freeman A, Bradshaw M, Holubkov R, Kahleova H. Blood Type Is Not Associated with Changes in Cardiometabolic Outcomes in Response to a Plant-Based Dietary Intervention. J Acad Nutr Diet. 2020;S2212-2672(20)31197-7. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Following Blood Type Diet While Taking Istradefylline: Common Questions

Is it safe to follow Blood Type Diet while taking Istradefylline?
We do not list a known interaction between Blood Type Diet and Istradefylline. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Istradefylline interact with any supplements?
Yes. Istradefylline has documented interactions with 138 supplements in our database — Blood Type Diet is not one of them. The Istradefylline interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Blood Type Diet monograph Uses, safety profile, and every drug interaction in one place Istradefylline drug information The full plain-English guide to this medication Istradefylline supplement interactions Every supplement checked against Istradefylline, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Istradefylline and Blood Type Diet?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.