Drug & supplement interaction

Bovine Colostrum + Defibrotide Sodium

Defibrotide Sodium brand name: Defitelio.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Bovine Colostrum and Defibrotide Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Bovine Colostrum and Defibrotide Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Defibrotide Sodium and Bovine Colostrum in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Bovine Colostrum at all — not against Defibrotide Sodium, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bovine Colostrum safety at a glance

Bovine Colostrum overall Use caution Generally well tolerated in most adults, but those with milk or dairy allergy should avoid it.
Pregnancy Use caution Not enough reliable safety data, so it is best to avoid unless your doctor approves.
Breastfeeding Use caution Safety is not well studied during breastfeeding, so use caution and ask your provider.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Defibrotide Sodium and Bovine Colostrum? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Bovine Colostrum and Defibrotide Sodium May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    Bovine Colostrum

    “Theoretical adverse effects to bovine colostrum include an allergic reaction in individuals allergic to bovine milk products. There is also some concern that bovine colostrum that is obtained from cows in countries where bovine spongiform encephalitis (BSE) has been reported might be unsafe, however, there is no research indicating that colostrum can be contaminated with the BSE-causing prion.”

    Bovine Colostrum · Natural Medicines adverse-effect record, reported in encephalitis.

    1 source cited
    1. 1825. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.

    Defibrotide Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Defibrotide Sodium. Read the label on DailyMed ›

  • Diarrhea Additional detail

    Bovine Colostrum

    “Orally, bovine colostrum has caused nausea and vomiting in an individual with HIV-related cryptosporidiosis. In clinical trials of bovine colostrum, bloating, nausea, diarrhea, and unsettled stomach have been reported as mild in nature by a few patients with a similar rate of occurrence as those taking a whey-based control.”

    Bovine Colostrum · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 4905. Greenberg PD, Cello JP. Treatment of severe diarrhea caused by Cryptosporidium parvum with oral bovine immunoglobulin concentrate in patients with AIDS. J Acquir Immune Defic Syndr Hum Retrovirol 1996;13:348-54. PubMed
    2. 92414. Duff WR, Chilibeck PD, Rooke JJ, Kaviani M, Krentz JR, Haines DM. The effect of bovine colostrum supplementation in older adults during resistance training. Int J Sport Nutr Exerc Metab. 2014 Jun;24(3):276-85. PubMed
    3. 101792. Sanctuary MR, Kain JN, Chen SY, et al. Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms. PLoS One. 2019;14(1):e0210064. PubMed
    4. 114819. Halasa M, Skonieczna-Zydecka K, Machalinski B, Bühner L, Baskiewicz-Halasa M. Six Weeks of Supplementation with Bovine Colostrum Effectively Reduces URTIs Symptoms Frequency and Gravity for Up to 20 Weeks in Pre-School Children. Nutrients 2023;15(16):3626 PubMed

    “Orally, bovine colostrum has caused elevated liver function tests in HIV patients treated for infectious diarrhea.”

    Bovine Colostrum · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 4905. Greenberg PD, Cello JP. Treatment of severe diarrhea caused by Cryptosporidium parvum with oral bovine immunoglobulin concentrate in patients with AIDS. J Acquir Immune Defic Syndr Hum Retrovirol 1996;13:348-54. PubMed

    Defibrotide Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Defibrotide Sodium. Read the label on DailyMed ›

  • Vomiting / Nausea Additional detail

    Bovine Colostrum

    Recorded for Bovine Colostrum in the same Natural Medicines adverse-effect record shown under Diarrhea above.

    Defibrotide Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Defibrotide Sodium. Read the label on DailyMed ›

Reported for Bovine Colostrum but not commonly for Defibrotide Sodium: a severe allergic reaction, hives, bloating or gas and itching.

Effects for Defibrotide Sodium come from the ADVERSE REACTIONS section of its FDA label; effects for Bovine Colostrum come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 3,546 voluntary FDA FAERS reports for Defibrotide Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Defibrotide Sodium

This page covers Bovine Colostrum only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Defibrotide Sodium page lists 202 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Danshen (major), Piracetam (major), Aconite (moderate), Allspice (moderate) and Aloe (moderate).

By severity: 2 major · 183 moderate · 17 minor.

From our pharmacist’s overview on the Defibrotide Sodium page

“Defibrotide (Defitelio) is an intravenous drug for severe veno-occlusive disease of the liver after a stem cell transplant, and part of how it works is by reducing the blood's tendency to clot. That makes bleeding the single thread running through this entire list, and it deserves real care.”

Reviewed by 2 · Jul 18, 2026

Open the Defibrotide Sodium interaction page

How much people look this up

Where Bovine Colostrum and Defibrotide Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bovine Colostrum
Steady interest

#1,299 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Defibrotide Sodium
Top half

#987 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bovine Colostrum reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Bovine Colostrum and Defibrotide Sodium records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bovine Colostrum

What is Bovine Colostrum?

Bovine Colostrum
  • Immune support
  • Gut health and digestion
  • Exercise recovery
  • Diarrhea (including infectious diarrhea)
  • Anti-inflammatory support

Bovine colostrum is the nutrient-rich first milk from cows, packed with antibodies, growth factors, and protein. Early research suggests it may help with gut health, certain types of diarrhea, and immune support, but more high-quality studies are needed. It is generally well tolerated, but people with milk allergy should avoid it, and pregnant or breastfeeding women should check with a healthcare provider first.

Colostrum (the first milk produced by cows after calving) · Powder, capsules, chewable tablets, liquid

An interaction check asks whether these two react with each other — it does not ask whether Bovine Colostrum is a good idea for someone in your situation. Here is what our Bovine Colostrum record says about it on its own.

Bovine Colostrum: dosing

There is no official standardized dose for bovine colostrum. Studies have used a wide range of amounts depending on the product and the condition being studied, so there is no single "right" dose for everyone.The best approach is to follow the directions on the product label and not take more than recommended.

From our Bovine Colostrum monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bovine Colostrum monograph & all interactions
Medication

About Defibrotide Injection

What Is Defibrotide Injection Used For?

Brand name: Defitelio

Defitelio (defibrotide injection) is used to treat hepatic veno-occlusive disease (VOD) — also called sinusoidal obstruction syndrome (SOS) — in adult and pediatric patients. This is a serious condition where small blood vessels in the liver become blocked, most often after a hematopoietic stem-cell transplant (HSCT).

Defitelio is specifically indicated when VOD is accompanied by kidney dysfunction or pulmonary (lung) dysfunction, making it a treatment for one of the most severe forms of this complication.

Most-Reported Side Effects for Defibrotide Sodium

From FAERS, the FDA’s public side-effect reporting system (3,546 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Venoocclusive disease 564 reports
Multiple organ dysfunction syndrome 343 reports
Venoocclusive liver disease 336 reports
Hypotension 159 reports
Hemorrhage 155 reports
See full Defibrotide Injection drug information
Keep checking

Other Drugs & Bovine Colostrum

Browse every other medication we’ve checked against Bovine Colostrum — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Bovine Colostrum against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Bovine Colostrum list.

See the full Bovine Colostrum interactions page
See every supplement checked against Defibrotide Sodium, ranked by severity
Evidence & sources

Bovine Colostrum References

The 8 references that drive our Bovine Colostrum monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  2. Greenberg PD, Cello JP. Treatment of severe diarrhea caused by Cryptosporidium parvum with oral bovine immunoglobulin concentrate in patients with AIDS. J Acquir Immune Defic Syndr Hum Retrovirol 1996;13:348-54. PubMed
  3. Duff WR, Chilibeck PD, Rooke JJ, Kaviani M, Krentz JR, Haines DM. The effect of bovine colostrum supplementation in older adults during resistance training. Int J Sport Nutr Exerc Metab. 2014 Jun;24(3):276-85. PubMed
  4. Sanctuary MR, Kain JN, Chen SY, et al. Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms. PLoS One. 2019;14(1):e0210064. PubMed
  5. Porcaro F, Caminiti L, Crisafulli G, Guglielmo F, Pajno GB. Anaphylaxis to cutaneous exposure to bovine colostrum based cream. Asian Pac J Allergy Immunol. 2019;37(1):9-11.
  6. Yan X, Pan X, Ding L, et al. Bovine colostrum to supplement the first feeding of very preterm infants: The PreColos randomized controlled trial. Clin Nutr 2023;42(8):1408-1417. PubMed
  7. Halasa M, Skonieczna-Zydecka K, Machalinski B, Bühner L, Baskiewicz-Halasa M. Six Weeks of Supplementation with Bovine Colostrum Effectively Reduces URTIs Symptoms Frequency and Gravity for Up to 20 Weeks in Pre-School Children. Nutrients 2023;15(16):3626 PubMed
  8. Simonsen MB, Kappel SS, Aunsholt L, Möller S, Sangild PT, Zachariassen G. Mineral supplementation for very preterm infants fed fortified human milk. J Pediatr Gastroenterol Nutr 2024;78(6):1389-1397. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bovine Colostrum and Defibrotide Sodium Together: Common Questions

Is it safe to take Bovine Colostrum with Defibrotide Sodium?
We do not list a known interaction between Bovine Colostrum and Defibrotide Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Bovine Colostrum and Defibrotide Sodium have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Defibrotide Sodium interact with any supplements?
Yes. Defibrotide Sodium has documented interactions with 202 supplements in our database — Bovine Colostrum is not one of them. The Defibrotide Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bovine Colostrum monograph Uses, safety profile, and every drug interaction in one place Defibrotide Injection drug information The full plain-English guide to this medication Defibrotide Sodium supplement interactions Every supplement checked against Defibrotide Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.