Medication interaction hub

What Supplements Interact with Defibrotide Sodium?

Defibrotide Sodium brand name: Defitelio. Every interaction below applies to the brands too.

202 Interactions 2 Major 183 Moderate 17 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Defibrotide Sodium? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Defibrotide Sodium against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Defibrotide (Defitelio) is an intravenous drug for severe veno-occlusive disease of the liver after a stem cell transplant, and part of how it works is by reducing the blood's tendency to clot. That makes bleeding the single thread running through this entire list, and it deserves real care. All 202 supplements on file can add to defibrotide's effect on clotting, and two carry a major rating, danshen and piracetam, because research shows each can blunt platelet function on its own.

The remaining 183 moderate and 17 minor entries repeat the same pattern with weaker evidence, mostly herbs, spices, and seed oils with antiplatelet activity seen in lab or animal studies. Anyone receiving defibrotide is already medically fragile and closely watched, so tell the transplant team about every supplement in use, and treat unexplained bruising, nosebleeds, or blood in stool as urgent.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 183 Minor 17 No known interaction 1,250

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Defibrotide Sodium: Top Interactions at a Glance

The Defibrotide Sodium supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 202 interacting ingredients — plus 1,250 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Defibrotide Sodium Combinations Today

The Defibrotide Sodium + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible N-acetyl Cysteine (nac) + Defibrotide Sodiumi

Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Capsicum + Defibrotide Sodiumi

Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Cocoa + Defibrotide Sodiumi

Theoretically, cocoa may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Vanadium + Defibrotide Sodiumi

Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Read the full interaction Moderate Likelihood Possible Strawberry + Defibrotide Sodiumi

In vitro and animal research suggests that strawberry extract can inhibit platelet aggregation due to its phenolic content.

Read the full interaction Major Likelihood Probable Danshen + Defibrotide Sodiumi

Theoretically, danshen may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Defibrotide Sodium

All 1,452 ingredients in our database, ranked by severity — 202 with a Defibrotide Sodium interaction on file and 1,250 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Defibrotide Sodium?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take N-acetyl Cysteine (nac) with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full N-acetyl Cysteine (nac) + Defibrotide Sodium answer

Can you take Capsicum with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Capsicum + Defibrotide Sodium answer

Can you take Cocoa with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cocoa may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Cocoa + Defibrotide Sodium answer

Can you take Vanadium with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.

Full Vanadium + Defibrotide Sodium answer

Can you take Strawberry with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro and animal research suggests that strawberry extract can inhibit platelet aggregation due to its phenolic content.

Full Strawberry + Defibrotide Sodium answer

Can you take Maral Root with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that maral root tincture can reduce platelet aggregation.

Full Maral Root + Defibrotide Sodium answer

Can you take Maritime Pine with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.

Full Maritime Pine + Defibrotide Sodium answer

Can you take Marjoram with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that marjoram extract inhibits platelet aggregation and adhesion.

Full Marjoram + Defibrotide Sodium answer

Can you take Melatonin with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, melatonin may have anticoagulant effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet dru...

Full Melatonin + Defibrotide Sodium answer

Can you take Mesoglycan with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combined use might increase bleeding risk.

Full Mesoglycan + Defibrotide Sodium answer

Can you take Methoxylated Flavones with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that some methoxylated flavones have antiplatelet effects.

Full Methoxylated Flavones + Defibrotide Sodium answer

Can you take Nattokinase with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.

Full Nattokinase + Defibrotide Sodium answer

Can you take Niacin with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin may have additive effects when used with anticoagulant or antiplatelet drugs.

Full Niacin + Defibrotide Sodium answer

Can you take Octacosanol with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, octacosanol might inhibit platelet aggregation; however, clinical research suggests that this effect may not be clinically si...

Full Octacosanol + Defibrotide Sodium answer

Can you take Onion with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of anticoagulant or antiplatelet drugs with onion might increase the risk of bleeding.

Full Onion + Defibrotide Sodium answer

Can you take Oolong Tea with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, oolong tea might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.

Full Oolong Tea + Defibrotide Sodium answer

Can you take Oregano with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Oregano + Defibrotide Sodium answer

Can you take Oregon Grape with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Full Oregon Grape + Defibrotide Sodium answer

Can you take Palm Oil with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.

Full Palm Oil + Defibrotide Sodium answer

Can you take Pantethine with Defibrotide Sodium?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.

Full Pantethine + Defibrotide Sodium answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Defibrotide Sodium is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Defibrotide Sodium, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Defibrotide Sodium sits in 1 interaction category. Open any one to see what the group means:

Anticoagulant/Antiplatelet Drugs 202 ingredients

Blood-thinning medications. Supplements with their own effects on clotting or platelets can add up with these drugs and raise bleeding risk.

202 of the supplement ingredients on this page reach Defibrotide Sodium through this category.

About Defibrotide Sodium

Defibrotide is an intravenous medication used to treat hepatic veno-occlusive disease (a serious liver condition) with kidney or lung complications in adults and children after stem-cell transplantation.

Generic name: Defibrotide Sodium  ·  Brand name: Defitelio.

See the full Defibrotide Injection drug information
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Take a Supplement Product? Check the Whole Bottle Against Defibrotide Sodium

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Defibrotide Sodium.

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Pharmacist Counseling Corner

Defibrotide Sodium & Supplements: Common Questions

What supplements interact with Defibrotide Sodium?
In our interaction database, 202 supplement and herbal ingredients have an interaction with Defibrotide Sodium on file — 2 rated major, 183 moderate, and 17 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Danshen, Piracetam, Bridelia.
Which Defibrotide Sodium supplement interactions are the most serious?
The 2 major-rated combinations — led by Danshen and Piracetam — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Defibrotide Sodium?
That depends entirely on which supplement. The honest answer for Defibrotide Sodium is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Defitelio have the same supplement interactions as Defibrotide Sodium?
Yes — Defitelio all contain Defibrotide Sodium, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Defibrotide Sodium and my other medications?
This page covers Defibrotide Sodium against supplements and herbal ingredients. Checking Defibrotide Sodium against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Defibrotide Injection drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

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How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.