Drug & supplement interaction

Juice Fasting + Defibrotide Sodium

Defibrotide Sodium brand name: Defitelio.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Juice Fasting and Defibrotide Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Juice Fasting and Defibrotide Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Defibrotide Sodium and Juice Fasting in our sources. This does not guarantee that the combination is completely free of risk — research on Juice Fasting alongside specific medications may be limited.

Worth understanding: our licensed dataset holds no drug-interaction record for Juice Fasting at all — not against Defibrotide Sodium, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

Juice Fasting is an eating pattern rather than something you take. Ask your pharmacist or doctor before changing how you eat while on a prescribed medicine: some medicines are dosed around meals, and a change in diet can change how they work. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Juice Fasting safety at a glance

Juice Fasting overall Use caution Generally low-risk for short periods in healthy adults, but lacks protein and fiber and may cause side effects.
Pregnancy Possibly Unsafe During pregnancy and lactation. Juice fasting is not intended to provide adequate nutrition and can result in electrolyte imbalances when used short-term, as we... Read the full pregnancy detail
Breastfeeding Possibly Unsafe During pregnancy and lactation. Juice fasting is not intended to provide adequate nutrition and can result in electrolyte imbalances when used short-term, as we... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Defibrotide Sodium and Juice Fasting? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Juice Fasting and Defibrotide Sodium May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so following Juice Fasting while taking the medicine can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Kidney problems Worth acting on Additional detail

    Juice Fasting

    “There is currently a limited amount of reliable information available on the adverse effects of juice fasting. However, juice fasts do not provide adequate nutrition and involve the consumption of large quantities of water, which can lead to electrolyte imbalances when used short-term and malnutrition when used long-term.”

    Juice Fasting · Natural Medicines adverse-effect record, reported in malnutrition.

    4 sources cited
    1. 103181. National Center for Complementary and Integrative Health. "Detoxes" and "Cleanses": What you need to know. Available at: https://www.nccih.nih.gov/health/detoxes-and-cleanses-what-you-need-to-know. Updated September 2019. Accessed on: June 15, 2020.
    2. 103134. Makkapati S, D'Agati VD, Balsam L. "Green Smoothie Cleanse" Causing Acute Oxalate Nephropathy. Am J Kidney Dis. 2018 Feb;71(2):281-286. PubMed
    3. 103135. Lien YHH. Juicing is not all juicy. Am J Med. Sept 2013;126(9):755-6. PubMed
    4. 103136. Getting JE, Gregoire JR, Phul A, Kasten MJ. Oxalate nephropathy due to 'juicing': case report and review. Am J Med. Sept 2013;126(9):768-72. PubMed

    “There are multiple case reports of oxalate-induced kidney injury in adults who are participating in juice fasts. It is likely that this kidney injury is due in part to the significant increase in oxalate consumption, as well as the reduction in calcium intake, that occurs during a juice fast.

    In one case report, a 65-year-old female developed acute oxalate nephropathy that progressed to end-stage renal disease after…”

    Juice Fasting · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    5 sources cited
    1. 103135. Lien YHH. Juicing is not all juicy. Am J Med. Sept 2013;126(9):755-6. PubMed
    2. 103136. Getting JE, Gregoire JR, Phul A, Kasten MJ. Oxalate nephropathy due to 'juicing': case report and review. Am J Med. Sept 2013;126(9):768-72. PubMed
    3. 103134. Makkapati S, D'Agati VD, Balsam L. "Green Smoothie Cleanse" Causing Acute Oxalate Nephropathy. Am J Kidney Dis. 2018 Feb;71(2):281-286. PubMed
    4. 112307. Chaudhari H, Michaud J, Srialluri N, Mahendrakar S, Granz C, Yudd M. Acute Oxalate Nephropathy Caused by Excessive Vegetable Juicing and Concomitant Volume Depletion. Case Rep Nephrol 2022;2022:4349673. PubMed
    5. 112308. Obadan OI, Yudd M. AKI in a Patient Engaged in Vegetable Juicing. Kidney360 2020;1(7):716-717. PubMed

    Defibrotide Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Defibrotide Sodium. Read the label on DailyMed ›

Reported for Juice Fasting but not commonly for Defibrotide Sodium: an electrolyte imbalance and dehydration.

Effects for Defibrotide Sodium come from the ADVERSE REACTIONS section of its FDA label; effects for Juice Fasting come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 3,546 voluntary FDA FAERS reports for Defibrotide Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Juice Fasting in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

During pregnancy and lactation. Juice fasting is not intended to provide adequate nutrition and can result in electrolyte imbalances when used short-term, as well as malnutrition when used long-term.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Defibrotide Sodium

This page covers Juice Fasting only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Defibrotide Sodium page lists 202 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Danshen (major), Piracetam (major), Aconite (moderate), Allspice (moderate) and Aloe (moderate).

By severity: 2 major · 183 moderate · 17 minor.

From our pharmacist’s overview on the Defibrotide Sodium page

“Defibrotide (Defitelio) is an intravenous drug for severe veno-occlusive disease of the liver after a stem cell transplant, and part of how it works is by reducing the blood's tendency to clot. That makes bleeding the single thread running through this entire list, and it deserves real care.”

Reviewed by 2 · Jul 18, 2026

Open the Defibrotide Sodium interaction page

How much people look this up

Where Juice Fasting and Defibrotide Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Juice Fasting
Steady interest

#1,390 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Defibrotide Sodium
Steady interest

#1,950 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Juice Fasting reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Juice Fasting and Defibrotide Sodium records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Eating pattern

About Juice Fasting

What is Juice Fasting?

  • Weight loss
  • Detoxification or 'cleansing'
  • Boosting fruit and vegetable intake
  • Improving energy or well-being
  • Resetting eating habits

Juice fasting means consuming only fruit and vegetable juices for a set period, often marketed for 'detox' or quick weight loss. There is little solid evidence that it cleanses the body or offers lasting health benefits, and your liver and kidneys already remove toxins on their own. Short juice fasts are low-risk for healthy adults, but they can be unsafe for some people, so check with a pharmacist or doctor first.

Fruit and vegetable juices · Fresh-pressed (cold-pressed) juices, store-bought juice blends, commercial juice-cleanse programs

An interaction check asks whether these two react with each other — it does not ask whether Juice Fasting is a good idea for someone in your situation. Here is what our Juice Fasting record says about it on its own.

Juice Fasting: dosing

There is no standardized or medically established way to do a juice fast. Programs vary widely in how many juices are consumed per day and how long the fast lasts.If you choose to try a short juice fast, keeping it brief (about one to three days), staying well hydrated with water, and easing back into solid food gradually are common-sense steps.

From our Juice Fasting monograph — the full record covers uses, side effects and every documented interaction.

Read the full Juice Fasting monograph & all interactions
Medication

About Defibrotide Injection

What Is Defibrotide Injection Used For?

Brand name: Defitelio

Defitelio (defibrotide injection) is used to treat hepatic veno-occlusive disease (VOD) — also called sinusoidal obstruction syndrome (SOS) — in adult and pediatric patients. This is a serious condition where small blood vessels in the liver become blocked, most often after a hematopoietic stem-cell transplant (HSCT).

Defitelio is specifically indicated when VOD is accompanied by kidney dysfunction or pulmonary (lung) dysfunction, making it a treatment for one of the most severe forms of this complication.

Most-Reported Side Effects for Defibrotide Sodium

From FAERS, the FDA’s public side-effect reporting system (3,546 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Venoocclusive disease 564 reports
Multiple organ dysfunction syndrome 343 reports
Venoocclusive liver disease 336 reports
Hypotension 159 reports
Hemorrhage 155 reports
See full Defibrotide Injection drug information
Keep checking

Other Drugs & Juice Fasting

Browse every other medication we’ve checked against Juice Fasting — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Juice Fasting against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Juice Fasting list.

See the full Juice Fasting interactions page
See every supplement checked against Defibrotide Sodium, ranked by severity
Evidence & sources

Juice Fasting References

The 8 references that drive our Juice Fasting monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Shetty P, Mooventhan A, Nagendra HR. Does short-term lemon honey juice fasting have effect on lipid profile and body composition in healthy individuals? J Ayurveda Integr Med. 2016 Mar;7(1):11-3. PubMed
  2. Huber R, Nauck M, Lüdtke R, Scharnagl H. Effects of one week juice fasting on lipid metabolism: a cohort study in healthy subjects. Forsch Komplementarmed Klass Naturheilkd. 2003 Feb;10(1):7-10. PubMed
  3. Makkapati S, D'Agati VD, Balsam L. "Green Smoothie Cleanse" Causing Acute Oxalate Nephropathy. Am J Kidney Dis. 2018 Feb;71(2):281-286. PubMed
  4. Lien YHH. Juicing is not all juicy. Am J Med. Sept 2013;126(9):755-6. PubMed
  5. Getting JE, Gregoire JR, Phul A, Kasten MJ. Oxalate nephropathy due to 'juicing': case report and review. Am J Med. Sept 2013;126(9):768-72. PubMed
  6. National Center for Complementary and Integrative Health. "Detoxes" and "Cleanses": What you need to know. Available at: https://www.nccih.nih.gov/health/detoxes-and-cleanses-what-you-need-to-know. Updated September 2019. Accessed on: June 15, 2020.
  7. Chaudhari H, Michaud J, Srialluri N, Mahendrakar S, Granz C, Yudd M. Acute Oxalate Nephropathy Caused by Excessive Vegetable Juicing and Concomitant Volume Depletion. Case Rep Nephrol 2022;2022:4349673. PubMed
  8. Obadan OI, Yudd M. AKI in a Patient Engaged in Vegetable Juicing. Kidney360 2020;1(7):716-717. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Following Juice Fasting While Taking Defibrotide Sodium: Common Questions

Is it safe to follow Juice Fasting while taking Defibrotide Sodium?
We do not list a known interaction between Juice Fasting and Defibrotide Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Juice Fasting and Defibrotide Sodium have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Defibrotide Sodium interact with any supplements?
Yes. Defibrotide Sodium has documented interactions with 202 supplements in our database — Juice Fasting is not one of them. The Defibrotide Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Juice Fasting monograph Uses, safety profile, and every drug interaction in one place Defibrotide Injection drug information The full plain-English guide to this medication Defibrotide Sodium supplement interactions Every supplement checked against Defibrotide Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Defibrotide Sodium and Juice Fasting?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.